Pharmacodynamic effects of ivabradine, a negative chronotropic agent, in healthy cats

Journal of Veterinary Cardiology

Volumn 13, Issue 4, 2011, Pages 231-242

  Cober, Richard E ^a   Schober, Karsten E ^a   Buffington, Tony C A ^a   Li, Xiaobai ^a   Riesen, Sabine C ^a,b   Bonagura, John D ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

Feline; Heart rate; I f inhibition; Tachycardia

Indexed keywords

IVABRADINE; PLACEBO;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CAT; DECREASED APPETITE; DIARRHEA; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG TOLERANCE; FEMALE; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; MALE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STARTLE REFLEX; TACHYCARDIA; TELEMETRY;

ADMINISTRATION, ORAL; ANIMALS; BENZAZEPINES; BLOOD PRESSURE; CARDIOTONIC AGENTS; CATS; CROSS-OVER STUDIES; FEMALE; HEART RATE; MALE; MONITORING, PHYSIOLOGIC; MYOCARDIUM; OXYGEN CONSUMPTION; SINGLE-BLIND METHOD; STARTLE REACTION; STRESS, PHYSIOLOGICAL; TIME FACTORS;

ANIMALIA; FELIDAE;

EID: 82255179207     PISSN: 17602734     EISSN: 18750834     Source Type: Journal    
DOI: 10.1016/j.jvc.2011.06.001     Document Type: Article

References (42)

1. E. Cote, A.M. Manning, D. Emerson, N.J. Laste, R.L. Malakoff, and N.K. Harpster Assessment of the prevalence of heart murmurs in overtly healthy cats J Am Vet Med Assoc 225 3 2004 384 388 (Pubitemid 38988967)
2. E.N. Peterson, N.S. Moise, C.A. Brown, H.N. Erb, and M.R. Slater Heterogeneity of hypertrophy in feline hypertrophic heart disease J Vet Intern Med 7 3 1993 183 189
3. K.M. Meurs, M.M. Norgard, M.M. Ederer, K.P. Hendrix, and M.D. Kittleson A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy Genomics 90 2 2007 261 264 (Pubitemid 47030809)
4. K.M. Meurs, X. Sanchez, R.M. David, N.E. Bowles, J.A. Towbin, P.J. Reiser, J.A. Kittleson, M.J. Munro, K. Dryburgh, K.A. Macdonald, and M.D. Kittleson A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy Hum Mol Genet 14 23 2005 3587 3593 (Pubitemid 41754660)
5. S.K. Liu, W.C. Roberts, and B.J. Maron Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs Am J Cardiol 72 12 1993 944 951 (Pubitemid 23298075)
6. M.D. Kittleson, K.M. Meurs, M.J. Munro, J.A. Kittleson, S.K. Liu, P.D. Pion, and J.A. Towbin Familial hypertrophic cardiomyopathy in Maine coon cats: an animal model of human disease Circulation 99 24 1999 3172 3180 (Pubitemid 29289084)
7. M.F. Cesta, C.J. Baty, B.W. Keene, I.W. Smoak, and D.E. Malarkey Pathology of end-stage remodeling in a family of cats with hypertrophic cardiomyopathy Vet Pathol 42 4 2005 458 467 (Pubitemid 40993856)
8. J.E. Rush, L.M. Freeman, N.K. Fenollosa, and D.J. Brown Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990-1999) J Am Vet Med Assoc 220 2 2002 202 207 (Pubitemid 135690545)
9. J. Payne, V. Luis Fuentes, A. Boswood, D. Connolly, H. Koffas, and D. Brodbelt Population and survival characteristics in 127 referred cats with hypertrophic cardiomyopathy (1997 to 2005) J Small Anim Pract 51 2010 540 547
10. C.E. Atkins, A.M. Gallo, I.D. Kurzman, and P. Cowen Risk factors, clinical signs, and survival in cats with a clinical diagnosis of idiopathic hypertrophic cardiomyopathy: 74 cases (1985-1989) J Am Vet Med Assoc 201 4 1992 613 618
11. K. Fox, I. Ford, P.G. Steg, M. Tendera, M. Robertson, and R. Ferrari Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial Lancet 372 9641 2008 817 821
12. K. Fox, J.S. Borer, A.J. Camm, N. Danchin, R. Ferrari, J.L. Lopez Sendon, P.G. Steg, J.C. Tardif, L. Tavazzi, and M. Tendera Resting heart rate in cardiovascular disease J Am Coll Cardiol 50 9 2007 823 830 (Pubitemid 47277500)
13. S.A. Smith, A.H. Tobias, and D.M. Fine Corticosteroid-associated congestive heart failure in 12 cats Intern J Appl Res Vet Med 2 2004 159 170
14. M.E. Mangoni, and J. Nargeot Genesis and regulation of the heart automaticity Physiol Rev 88 3 2008 919 982
15. A. Bucchi, M. Baruscotti, and R.B. Robinson Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current J Mol Cell Cardiol 43 1 2007 39 48 (Pubitemid 46898426)
16. A.H. Sadrzadeh Rafie, G.W. Sungar, and F.E. Dewey Prognostic value of double product reserve Eur J Cardiovasc Prev Rehabil 15 5 2008 541 547
17. S.C. Riesen, W. Ni, C.A. Carnes, K.J. Lindsey, M.A. Phelps, and K.E. Schober Pharmacokinetics of oral ivabradine in healthy cats J Vet Pharmacol Ther 2011 (Epub, Dec. 2010)
18. M. Baruscotti, A. Bucchi, and D. Difrancesco Physiology and pharmacology of the cardiac pacemaker ("funny") current Pharmacol Ther 107 1 2005 59 79 (Pubitemid 40800408)
19. A. Berdeaux Preclinical results with I(f) current inhibition by ivabradine Drugs 67 Suppl. 2 2007 25 33 (Pubitemid 350114593)
20. f inhibition with ivabradine: electrophysiological effects and safety Drug Saf 31 2 2008 95 107 (Pubitemid 351175614)
21. A.J. Camm, and C.P. Lau Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology Drugs R D 4 2 2003 83 89 (Pubitemid 37062655)
22. A. Bucchi, M. Baruscotti, and D. DiFrancesco Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine J Gen Physiol 120 1 2002 1 13 (Pubitemid 34755772)
23. S.M. Gardiner, P.A. Kemp, J.E. March, and T. Bennett Acute and chronic cardiac and regional haemodynamic effects of the novel bradycardic agent, S6257, in conscious rats Br J Pharmacol 115 4 1995 579 586
24. L. Simon, B. Ghaleh, L. Puybasset, J.F. Giudicelli, and A. Berdeaux Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs J Pharmacol Exp Ther 275 2 1995 659 666 (Pubitemid 26023611)
25. A.M. Alings, and L.N. Bouman Electrophysiology of the ageing rabbit and cat sinoatrial node-a comparative study Eur Heart J 14 9 1993 1278 1288 (Pubitemid 23288300)
26. J.S. Borer, and J.Y. Heuzey Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor Am J Ther 15 5 2008 461 473
27. R. Joannides, N. Moore, M. Lacob, P. Compagnon, G. Lerebours, J.F. Menard, and C. Thuillez Comparative effects of ivabradine, a selective heart rate-lowering agent, and propanolol on systemic and cardiac haemodynaimcs at rest and during exercise Br J Clin Pharm 61 2 2006 127 137 (Pubitemid 43382606)
28. Riesen SC, Schober, KE, Smith DN, Otoni CC, Li X, Bonagura JD. Effects of ivabradine on heart rate and left ventricular function in healthy cats and cats with hypertrophic cardiomyopathy. Am J Vet Res, in press.
29. M. Bohm, and J.C. Reil Perspectives of I(f) inhibition by ivabradine in cardiology Drugs 67 Suppl. 2 2007 43 49
30. J.C. Tardif Clinical results of I(f) current inhibition by ivabradine Drugs 67 Suppl. 2 2007 35 41
31. U.K. Prasad, D. Gray, and H. Purcell Review of the I(f) selective channel inhibitor ivabradine in the treatment of chronic stable angina Adv Ther 26 2 2009 127 137
32. L. Lopez Bescos, A. Filipova, and R. Martos Long-term safety and efficacy of ivabradine in patiens with chronic stable angina Cardiology 108 2007 387 396 (Pubitemid 350130092)
33. S. Hanas, A. Tidholm, A. Egenvall, and B.S. Holst Twenty-four hour Holter monitoring of unsedated healthy cats in the home environment J Vet Cardiol 11 1 2009 17 22
34. W.A. Ware Twenty-four-hour ambulatory electrocardiography in normal cats J Vet Intern Med 13 3 1999 175 180
35. J.M. MacGregor, J.E. Rush, E.A. Rozanski, D.M. Boothe, A.A. Belmonte, and L.M. Freeman Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats Am J Vet Res 69 1 2008 39 44 (Pubitemid 351181568)
36. M. Quinones, D.C. Dyer, W.A. Ware, and R. Mehvar Pharmacokinetics of atenolol in clinically normal cats Am J Vet Res 57 7 1996 1050 1053 (Pubitemid 26234023)
37. K. Fox, I. Ford, P.G. Steg, M. Tendera, M. Roberston, and R. Ferrari Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial Eur Heart J 30 19 2009 2337 2345
38. A.M. Belew, T. Barlett, and S.A. Brown Evaluation of the white-coat effect in cats J Vet Intern Med 13 2 1999 134 142
39. J.A. Abbott Heart rate and heart rate variability of healthy cats in home and hospital environments J Feline Med Surg 7 3 2005 195 202 (Pubitemid 40716485)
40. P. Colin, B. Ghaleh, X. Monnet, J. Su, L. Hittinger, J.F. Giudicelli, and A. Berdeaux Contributions of heart rate and contractility to myocardial oxygen balance during exercise Am J Physiol Heart Circ Physiol 284 2 2003 H676 H682 (Pubitemid 36142896)
41. C.A.T. Buffington, and K. Pacak Increased plasma norepinephrine concentration in cats with interstitial cystitis J Urol 165 2001 2051 2054
42. C. Twiss, L. Kilpatrick, M. Craske, C.A. Buffington, E. Ornitz, L.V. Rodriguez, E.A. Mayer, and B.D. Naliboff Increased startle responses in interstitial cystitis: evidence for central hyperresponsiveness to visceral threat J Urol 181 2009 2127 2133