Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7435-7440

  Hajipour, Abdol R ^a,b   Guo, Lian Wang ^a   Pal, Arindam ^a   Mavlyutov, Timur ^a   Ruoho, Arnold E ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b ISFAHAN UNIVERSITY OF TECHNOLOGY   (Iran)

Author keywords

Electron donating; Isoquinoline; Methoxy; para Position; Selectivity; Sigma 2 receptor

Indexed keywords

2 [4 (7 NITRO 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]ISOINDOLINE 1,3 DIONE; 2 HYDROXY 3 METHOXY N [4 (7 NITRO 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]BENZAMIDE; 2 HYDROXY 4 IODO 3 METHOXY N [4 (7 NITRO 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]BENZAMIDE; 2,3 DIMETHOXY N [4 (7 NITRO 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]BENZAMIDE; 2,3,4 TRIMETHOXY N [4 (7 NITRO 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]BENZAMIDE; BENZAMIDEISOQUINOLINE DERIVATIVE; BENZIDEPHENYL GROUP; CHEMICAL COMPOUND; HALOPERIDOL; ISOQUINOLINE DERIVATIVE; METHOXY GROUP; N [4 (6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL] 2 HYDROXY 3 METHOXYBENZAMIDE; N [4 (6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL] 3 NITROBENZAMIDE; N [4 (6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL] 4 NITROBENZAMIDE; N [4 (6,7 DIMETHOXY 3,4 DIHYDROISOQUINOLINE 2(1H) YL)BUTYL]BENZAMIDE; NITRO GROUP; OPIATE RECEPTOR AFFECTING AGENT; PHENYL GROUP; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTRON; NONHUMAN; RAT; RECEPTOR AFFINITY; SENSITIVITY ANALYSIS;

ANIMALS; BENZAMIDES; ELECTRONS; ISOQUINOLINES; LIGANDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA;

EID: 82255175511     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.046     Document Type: Article

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