Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with moderate-to-severe aortic stenosis

Heart

Volumn 97, Issue 24, 2011, Pages 2023-2028

  Natorska, Joanna ^a,b   Bykowska, Ksenia ^c   Hlawaty, Marta ^b   Marek, Grzegorz ^a   Sadowski, Jerzy ^a,b   Undas, Anetta ^a,b  

^a Krakowski Szpital Specjalistyczny Im Jana Pawła II   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA THROMBOGLOBULIN; CD40 LIGAND; PADGEM PROTEIN; PROTHROMBIN; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX; VON WILLEBRAND FACTOR;

AGED; AORTA STENOSIS; ARTICLE; BLEEDING; BLOOD CLOTTING; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNOLOCALIZATION; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBIN TIME; THROMBOCYTE ACTIVATION; VON WILLEBRAND DISEASE;

AGED; AORTIC VALVE STENOSIS; BLOOD COAGULATION; DENSITOMETRY; DISEASE PROGRESSION; ECHOCARDIOGRAPHY, DOPPLER; ELECTROPHORESIS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MOLECULAR WEIGHT; PLATELET ACTIVATION; PROGNOSIS; SEVERITY OF ILLNESS INDEX; THROMBIN; VON WILLEBRAND DISEASES; VON WILLEBRAND FACTOR;

EID: 82255163061     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2010.217273     Document Type: Article

References (27)

1. Yetkin E, Waltenberger J. Molecular and cellular mechanisms of aortic stenosis. Int J Cardiol 2009;135:4-13.
2. Parolari A, Loardi C, Mussoni L, et al. Nonrheumatic calcific aortic stenosis: an overview from basic science to pharmacological prevention. Eur J Cardiothorac Surg 2009;35:493-504.
3. Sadler JE. Aortic stenosis, von Willebrand factor, and bleeding. N Engl J Med 2003;349:323-5. (Pubitemid 36886236)
4. Favaloro EJ. An update on the von Willebrand factor collagen binding assay: 21 years of age and beyond adolescence but not yet a mature adult. Semin Thromb Hemost 2007;33:727-44. (Pubitemid 351158442)
5. Sadler JE. New concepts in von Willebrand disease. Annu Rev Med 2005;56:173-91. (Pubitemid 40299779)
6. Tsai HM, Sussman II, Nagel RL. Shear stress enhances the proteolysis of von Willebrand factor in plasma. Blood 1994;83:2171-9. (Pubitemid 24112728)
7. Warkentin TE, Moore JC, Anand SS, et al. Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome. Transfus Med Rev 2003;17:272-86. (Pubitemid 37310934)
8. Pareti FL, Lattuada A, Bressi C, et al. Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis. Circulation 2000;102:1290-5.
9. Vincentelli A, Susen S, Le Tourneau T, et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med 2003;349:343-9. (Pubitemid 36886240)
10. Olsson M, Hultcrantz R, Schulman S, et al. Acquired platelet dysfunction may be an aetiologic factor in Heyde's syndrome: normalization of bleeding time after aortic valve replacement. J Intern Med 2002;252:516-23.
11. Dimitrow PP, Hlawaty M, Undas A, et al. Effect of aortic valve stenosis on haemostasis is independent from vascular atherosclerotic burden. Atherosclerosis 2009;204:e103-8.
12. Diehl P, Nagy F, Sossong V, et al. Increased levels of circulating microparticles in patients with severe aortic valve stenosis. Thromb Haemost 2008;99:709-11.
13. Natorska J, Marek G, Hlawaty M, et al. Evidence for tissue factor expression in aortic valves in patients with aortic stenosis. Pol Arch Med Wewn 2009;119:636-42.
14. Breyne J, Juthier F, Croseaux D, et al. Atherosclerotic-like process in aortic stenosis: activation of the tissue factor-thrombin pathway and potential role through osteopontin alternation. Atherosclerosis 2010;213:369-76.
15. Dimitrow PP, Undas A. Letter by Dimitrow and Undas regarding article "Functional impairment of von Willebrand factor in hypertrophic cardiomyopathy: relation to rest and exercise obstruction". Circulation 2009;119:e590.
16. Douglas PS, Stainback RF, Weissman NJ, et al. Appropriateness criteria for transthoracic and transesophageal echocardiography. J Am Coll Cardiol 2007;50:187-204.
17. Teirstein P, Yeager M, Yock PG. Doppler echocardiographic measurement of aortic valve area in aortic stenosis: a noninvasive application of the Gorlin formula. J Am Coll Cardiol 1986;8:1059-65. (Pubitemid 16009090)
18. Mazurier C. In vitro evaluation of haemostatic value of the LFB-von Willebrand factor concentrate. Haemophilia 1998;4(Suppl 3):40-3. (Pubitemid 28561095)
19. Ruggeri ZM, Zimmerman TS. Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets. J Clin Invest 1980;65:1318-25. (Pubitemid 10122373)
20. Makris M. Gastrointestinal bleeding in von Willebrand disease. Thromb Res 2006;118 (Suppl 1):S13-S17.
21. Yoshida K, Tobe S, Kawata M. Acquired and reversible von Willebrand disease with high shear stress aortic valve stenosis. Ann Thorac Surg 2006;81:490-4. (Pubitemid 43120541)
22. Otto CM, Lind BK, Kitzman DW, et al. Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med 1999;341:142-7. (Pubitemid 29325741)
23. Lowenberg EC, Meijers JC, Levi M. Platelet-vessel wall interactions in health and disease. Neth J Med 2010;68:242-51.
24. Amelot AA, Tagzirt M, Ducouvret G, et al. Platelet factor 4 (CXCL4) seals blood clots by altering the structure of fibrin. J Biol Chem 2007;282:710-20. (Pubitemid 47076616)
25. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev 2007;21:131-42. (Pubitemid 46541695)
26. Undas A, Windyga J, Bykowska K, et al. Heyde's syndrome without a decrease in large von Willebrand factor multimers: a case of intestinal bleedings reversed by valve replacement in a patient with aortic stenosis. Thromb Haemost 2009;101:773-4.
27. Panzer S, Badr Eslam R, Schneller A, et al. Loss of high-molecular-weight von Willebrand factor multimers mainly affects platelet aggregation in patients with aortic stenosis. Thromb Haemost 2010;103:408-14.