Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz

Volumn 106, Issue 7, 2011, Pages 814-822

  El Lakkany, Naglaa Mohamed ^a   el Din, Sayed Hassan Seif ^a   Sabra, Abdel Nasser Abdel Aal ^a   Hammam, Olfat Ali ^b  

^a E   (Egypt)

^b Theodor Bilharz Research Institute   (Egypt)

Author keywords

Mefloquine; Praziquantel; Reinfection; Schistosoma mansoni; Therapeutic efficacy

Indexed keywords

MUS; SCHISTOSOMA MANSONI;

EID: 82255162150     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762011000700006     Document Type: Article

References (45)

1. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR 2007. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med 4: e14.
2. AlKadi HO 2007. Antimalarial drug toxicity: a review. Chemotherapy 53: 385-391.
3. Botros S, Sayed H, Amer N, El-Ghannam M, Bennett JL, Day TA 2005. Current status of sensitivity to praziquantel in a focus of potential drug resistance in Egypt. Int J Parasitol 35: 787-791.
4. Botros SS, Bennett JL 2007. Praziquantel resistance. Expert Opin Drug Discov 2 (Suppl. 1): S35-S40.
5. Botros SS, Mahmoud MR, Moussa MM, Nosseir MM 2007. Immunohistopathological and biochemical changes in Schistosoma mansoni-infected mice treated with artemether. J Infect 55: 470-477.
6. Caffrey CR 2007. Chemotherapy of schistosomiasis: present and future. Curr Opin Chem Biol 11: 433-439.
7. Cheever AW 1968. Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ 39: 328-331.
8. Clegg JA 1965. In vitro cultivation of Schistosoma mansoni. Exp Parasitol 16: 133-147.
9. Doenhoff M, Cioli D, Utzinger J 2008. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis 21: 659-667.
10. Duvall RH, De Witt WB 1967. An improved perfusion technique for recovering adult schistosomes from laboratory animals. Am J Trop Med Hyg 16: 483-486.
11. Engels D 2002. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop 82: 139-146.
12. Fallon PG, Doenhoff MJ 1995. Active immunization of mice with Schistosoma mansoni worm membrane antigens enhances efficacy of praziquantel. Parasite Immunol 7: 261-268.
13. Fenwick A 2003. Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends Parasitol 19: 509-515.
14. Fenwick A, Webster JP 2006. Schistosomiasis: challenges for control, treatment and drug resistance. Curr Opin Infect Dis 19: 577-582.
15. Frohberg H 1984. Results of toxicological studies on praziquantel. Arzneimittelforschung 4: 1137-1144.
16. Geary TG, Woo K, McCarthy JS, Mackenzie CD, Horton J, Prichard RK, de Silva NR, Olliaro PL, Lazdins-Helds JK, Engels DA, Bundy DA 2010. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 40: 1-13.
17. Gonnert R, Andrews P 1977. Praziquantel, a new broad spectrum antischistosomal agent. Z Parasitenkd 52: 129-150.
18. Ismail M, Botros S, Metwally A, William S, Farghally A, Tao LF, Day TA, Bennett JL 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60: 932-935.
19. Ismail M, Metwally A, Farghaly A, Bruce J, Tao LF, Bennett JL 1996. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55: 214-418.
20. Keiser J, Chollet J, Xiao S, Mei J, Jiao P, Utzinger J, Tanner M 2009. Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLOS Negl Trop Dis 3: e350.
21. Keiser J, Utzinger J 2007. Artemisinins and synthetic trioxolanes in the treatment of helminth infections. Curr Opin Infect Dis 20: 605-612.
22. King CH, Dickman K, Tisch DJ 2005. Reassessment of the cost of chronic helminthic infection: a meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 365: 1561-1569.
23. Liang YS, John BI, Boyd DA 1987. Laboratory cultivation of schistosome vector snails and maintenance of schistosome life cycles. Proceeding of the 1st Sino-American Symposium 1: 34-48.
24. Mehlhorn H, Becker B, Andrews P, Thomas H, Frenkel JK 1981. In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni: a light and electron microscopic study. Arzneimittelforschung 31: 544-554.
25. Miller HRP, Newlands GFJ, McKellar A, Inglis L, Coulson PS, Wilson RA 1994. Hepatic recruitment of mast cells occurs in rats but not in mice infected with Schistosoma mansoni. Parasite Immunol 16: 145-155.
26. Nassauw LV, Toovey S, Van Op den bosch J, Jean-Pierre, Timmermans J 2008. Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice. Travel Med Infect Dis 6: 253-258.
27. Nwaka S, Hudson A 2006. Innovative lead discovery strategies for tropical diseases. Nat Rev Drug Discov 5: 941-955.
28. Pellegrino J, Oliveira CA, Faria J, Cunha AS 1962. New approach to the screening of drugs in experimental schistosomiasis mansoni in mice. Am J Trop Med Hyg 11: 201-215.
29. Pham YT, Nosten F, Farinotti R, White NJ, Gimenez F 1999. Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria. Int J Clin Pharmacol Ther 37: 58-61.
30. Polderman AM, Gryseels B, Gerold JL, Mpamila K, Manshande JP 1984. Side effects of praziquantel in the treatment of Schistosoma mansoni in Maniema, Zaire. Trans R Soc Trop Med Hyg 78: 752-754.
31. Riou M, Koch C, Delaleu B, Berthon P, Kerboeuf D 2005. Immunolocalisation of an ABC transporter, P-glycoprotein, in the eggshells and cuticles of free-living and parasitic stages of Haemonchus contortus. Parasitol Res 96: 142-148.
32. Sabah AA, Fletcher C, Webbe G, Doenhoff MG 1986. Schistosoma mansoni: chemotherapy of infections of different ages. Exp Parasitol 61: 294-303.
33. Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL 2008. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med 4: 407-412.
34. Seif el-Din SH 2007. Prophylactic effect of artesunate with/without antioxidants on juvenile and adult Egyptian strain of Schistosoma mansoni in mice. Az J Pharm Sci 35: 80-93.
35. Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J 2006. Schistosomiasis and water resources development: systematic review, meta-analysis and estimates of people at risk. Lancet Infect Dis 6: 411-425.
36. Utzinger J, Shuhua X, N'Goran EK, Bergquist R, Tanner M 2001. The potential of artemether for the control of schistosomiasis. Int J Parasitol 31: 1549-1562.
37. Utzinger J, Xiao SH, Tanner M, Keiser J 2007. Artemisinins for schistosomiasis and beyond. Curr Opin Investig Drugs 8: 105-116.
38. Von Lichtenberg FC 1962. Host response to eggs of Schistosoma mansoni. I. Granuloma formation in the sensitized laboratory mouse. Am J Pathol 41: 711-731.
39. White NJ 2008. Qinghaosu (artemisinin): the price of success. Science 320: 330-334.
40. WHO-World Health Organization 2000. Report of the WHO informal consultation on schistosomiasis in low transmission areas: control strategies and criteria for elimination, WHO, London, 56 pp.
41. Xiao SH, Booth M, Tanner M 2000. The prophylactic effects of artemether against Schistosoma japonicum infections. Parasitol Today 16: 122-126.
42. Xiao SH, Keiser J, Chollet J, Utzinger J, Dong Y, Endriss Y, Vennerstrom JL, Tanner M 2007. The in vitro and in vivo activities of synthetic trioxolanes on major human schistosome species. Antimicrob Agents Chemother 51: 1440-1445.
43. Xiao SH, Mei JY, Jiao PY 2009. The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum. Parasitol Res 106: 237-246.
44. Xiao SH, Mei JY, Jiao PY 2011. Effect of mefloquine administered orally at single, multiple or combined with artemether, artesunate or praziquantel in treatment of mice infected with. Schistosoma japonicum. Parasitol Res 108: 399-406.
45. Xiao SH, Tanner M, N'Goran EK, Utzinger J, Chollet J, Bergquist R, Chen M, Zheng J 2002. Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop 82: 175-181.