Improved spinal fusion efficacy by long-term delivery of bone morphogenetic protein-2 in a rabbit model

Acta Orthopaedica

Volumn 82, Issue 6, 2011, Pages 756-760

  Lee, Jae Wook ^a   Lee, Saehyoung ^b   Lee, Sun Hwa ^a   Yang, Hee Seok ^b   Im, Gun II ^c   Kim, Chang Sung ^d   Park, Jung Ho ^a   Kim, Byung Soo ^b  

^a Korea University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Dongguk University Ilsan Hospital   (South Korea)

^d Yonsei University College of Dentistry   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; HEPARIN CONJUGATED PLGA NANOSPHERE; NANOSPHERE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BONE GRAFT; BONE RADIOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HISTOPATHOLOGY; ILIAC CREST; NONHUMAN; PALPATION; RABBIT; SPINE FUSION; TENSILE STRENGTH;

ADULT; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE TRANSPLANTATION; DRUG DELIVERY SYSTEMS; HUMANS; MODELS, ANIMAL; OSTEOGENESIS; RABBITS; SPINAL FUSION; TENSILE STRENGTH; TIME FACTORS; TREATMENT OUTCOME;

EID: 82255161161     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.3109/17453674.2011.636675     Document Type: Article

References (18)

1. Akamaru T, Suh D, Boden S D, Kim HS, Minamide A, Louis-Ugbo J. Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion. Spine. 2003; 28 (5): 429-34 (Pubitemid 36330828)
2. Benglis D, Wang M Y, Levi A D. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery (Suppl 2) 2008; 62 (5):ONS423-31; discussion ONS31.
3. Boden S D, Schimandle J H, Hutton W C. Lumbar intertransverse-process spinal arthrodesis with use of a bovine bone-derived osteoinductive pro-tein. J Bone Joint Surg (Am) 1995; 77 (9): 1404-17
4. Burkus J K, Gornet M F, Dickman C A, Zdeblick T A. Anterior lumbar inter-body fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 2002; 15 (5): 337-49
5. Dimar J R, Glassman S D, Burkus K J, Carreon L Y. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 2006; 31 (22): 2534-9 (Pubitemid 44632234)
6. Hsu W K, Wang J C. The use of bone morphogenetic protein in spine fusion. Spine J 2008; 8 (3): 419-25
7. Jeon O, Kang S W, Lim H W, Chung J H, Kim B S. Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(L-lactide-co-glycolide) nanospheres and fibrin gel. Biomaterials 2006; 27 (8): 1598-607 (Pubitemid 41739585)
8. Jeon O, Song S J, Kang S W, Putnam A J, Kim B S. Enhancement of ectopic bone formation by bone morphogenetic protein-2 released from a heparin-conjugated poly(L-lactic-co-glycolic acid) scaffold. Biomaterials 2007; 28 (17): 2763-71 (Pubitemid 46413347)
9. Jeon O, Song S J, Yang H S, Bhang S H, Kang S W, Sung M A, Lee J H, Kim B S. Long-term delivery enhances in vivo osteogenic efficacy of bone mor-phogenetic protein-2 compared to short-term delivery. Biochem Bioph Res Comm 2008; 369 (2): 774-80
10. La W G, Kang S W, Yang H S, Bhang S H, Lee S H, Park J H, Kim B S. The efficacy of bone morphogenetic protein-2 depends on its mode of delivery. Artif Organs 2010; 34 (12): 1150-3
11. Liao S S, Guan K, Cui F Z, Shi S S, Sun T S. Lumbar spinal fusion with a mineralized collagen matrix and rhBMP-2 in a rabbit model. Spine 2003; 28 (17): 1954-60 (Pubitemid 37082660)
12. Lieberman J R, Daluiski A, Einhorn T A. The role of growth factors in the repair of bone - Biology and clinical applications. J Bone Joint Surg Am) 2002; 84 (6): 1032-44
13. Minamide A, Kawakami M, Hashizume H, Sakata R, Tamaki T. Evaluation of carriers of bone morphogenetic protein for spinal fusion. Spine 2001; 26 (8): 933-9 (Pubitemid 32373980)
14. Petite H, Viateau V, Bensaid W, Meunier A, de Pollak C, Bourguignon M, Oudina K, Sedel L, Guillemin G. Tissue-engineered bone regeneration. Nat Biotechnol 2000; 18 (9): 959-63 (Pubitemid 32977376)
15. Ruhe P Q, Boerman O C, Russel F G M, Mikos A G, Spauwen P HM , Jansen J A. In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin. J Mater Sci Mater Med 2006; 17 (10): 919-27 (Pubitemid 44411286)
16. Takada T, Katagiri T, Ifuku M, Morimura N, Kobayashi M, Hasegawa K, Ogamo A, Kamijo R. Sulfated polysaccharides enhance the biological activities of bone morphogenetic proteins. J Biol Chem 2003; 278 (44): 43229-35 (Pubitemid 37345942)
17. Vaccaro A R, Whang P G, Patel T, Phillips F M, Anderson D G, Albert T J, Hilibrand A S, Brower R S, Kurd M F, Appannagari A, Patel M, Fischgr-und J S. The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: Minimum 4-year follow-up of a pilot study. Spine J 2008; 8 (3): 457-65 (Pubitemid 351608966)
18. Zhao B H, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U I, Koike T, Takaoka K, Kamijo R. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 2006; 281 (32): 23246-53.