KCNJ2 Variant of Unknown Significance Reclassified as Long QT Syndrome Causing Ventricular Fibrillation

Canadian Journal of Cardiology

Volumn 27, Issue 6, 2011, Pages 870.e11-870.e13

  Obeyesekere, Manoj N ^a   Klein, George J ^a   Conacher, Susan ^a   Krahn, Andrew D ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CANDESARTAN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; METHIONINE; PROCAINAMIDE;

ADULT; ARTICLE; CASE REPORT; DROWNING; ECHOCARDIOGRAPHY; EXERCISE TEST; FEMALE; GENETIC SCREENING; HEART ARREST; HEART PALPITATION; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPERTENSION; LONG QT SYNDROME; PATHOGENICITY; PERIODIC PARALYSIS; POINT MUTATION; POTASSIUM BLOOD LEVEL; RESUSCITATION; SPONTANEOUS ABORTION; SYNCOPE;

EID: 82155196439     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2011.05.004     Document Type: Article

References (5)

1. Eckhardt L.L., Farley A.L., Rodriguez E., et al. KCNJ2 mutations in arrhythmia patients referred for LQT testing: a mutation T305A with novel effect on rectification properties. Heart Rhythm 2007, 4:323-329.
2. Zhang L., Benson D.W., Tristani-Firouzi M., et al. Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation 2005, 111:2720-2726.
3. Chattha I.S., Sy R.W., Yee R., et al. Utility of the recovery electrocardiogram after exercise: a novel indicator for the diagnosis and genotyping of long QT syndrome?. Heart Rhythm 2010, 7:906-911.
4. Hedley P.L., Jorgensen P., Schlamowitz S., et al. The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat 2009, 30:1486-1511.
5. Donaldson M.R., Jensen J.L., Tristani-Firouzi M., et al. PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome. Neurology 2003, 60:1811-1816.