Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 9, 2011, Pages 518-524

  Honjo, Hiroaki ^a   Uwai, Yuichi ^a   Aoki, Youhei ^a   Iwamoto, Kikuo ^a  

^a AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

inhibition; NSAID; organic anion transporter; stereoselectivity; transport

Indexed keywords

ESTRONE SULFATE; FLURBIPROFEN; IBUPROFEN; METHOTREXATE; NAPROXEN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG UPTAKE; ENANTIOMER; IC 50; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FLURBIPROFEN; HUMANS; IBUPROFEN; INHIBITORY CONCENTRATION 50; NAPROXEN; OOCYTES; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; STEREOISOMERISM; XENOPUS LAEVIS;

EID: 82155175619     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.779     Document Type: Article

References (15)

1. El-Sheikh AA, Masereeuw R, Russel FG,. Mechanisms of renal anionic drug transport. Eur J Pharmacol 2008; 585: 245-255.
2. Motohashi H, Sakurai Y, Saito H, et al,. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 2002; 13: 866-874. (Pubitemid 34274082)
3. Thyss A, Milano G, Kubar J, Namer M, Schneider M,. Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet 1986; 327: 256-258. (Pubitemid 16132863)
4. Maiche AG,. Acute renal failure due to concomitant action of methotrexate and indomethacin. Lancet 1986; 327: 1390. (Pubitemid 16121925)
5. Takeda M, Khamdang S, Narikawa S, et al,. Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther 2002; 302: 666-671. (Pubitemid 34787234)
6. Uwai Y, Taniguchi R, Motohashi H, Saito H, Okuda M, Inui K,. Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet 2004; 19: 369-374.
7. Nozaki Y, Kusuhara H, Kondo T, et al,. Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. J Pharmacol Exp Ther 2007; 322: 1162-1170.
8. Maeda A, Tsuruoka S, Kanai Y, et al,. Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells. Eur J Pharmacol 2008; 596: 166-172.
9. Knadler MP, Brater DC, Hall SD,. Stereoselective disposition of flurbiprofen in normal volunteers. Br J Clin Pharmacol 1992; 33: 369-375.
10. Mano Y, Usui T, Kamimura H,. Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liver. Drug Metab Dispos 2007; 35: 1182-1187. (Pubitemid 46956440)
11. Itoh T, Saura Y, Tsuda Y, Yamada H,. Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin. Chirality 1997; 9: 643-649. (Pubitemid 27479370)
12. Uwai Y, Iwamoto K,. Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: comparison with methotrexate. Drug Metab Pharmacokinet 2010; 25: 163-169.
13. Cha SH, Sekine T, Fukushima J, et al,. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 2001; 59: 1277-1286. (Pubitemid 32385197)
14. Uwai Y, Ida H, Tsuji Y, Katsura T, Inui K,. Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res 2007; 24: 811-815. (Pubitemid 46411965)
15. Ueo H, Motohashi H, Katsura T, Inui K,. Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol 2005; 70: 1104-1113. (Pubitemid 41262086)