The dependence of preferred competitive racing distance on muscle fibre type composition andACTN3genotype in speed skaters

Experimental Physiology

Volumn 96, Issue 12, 2011, Pages 1302-1310

  Ahmetov, Ildus I ^a,b,c,d   Druzhevskaya, Anastasiya M ^b   Lyubaeva, Ekaterina V ^c   Popov, Daniil V ^c   Vinogradova, Olga L ^c   Williams, Alun G ^d  

^a KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^b St Petersburg Research Institute of Physical Culture   (Russian Federation)

^c INSTITUTE OF BIOMEDICAL PROBLEMS   (Russian Federation)

^d MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ 3;

ARTICLE; ATHLETE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN TISSUE; LEG MUSCLE; MALE; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE FUNCTION; MUSCLE TWITCH; NORMAL HUMAN; SPORT;

EID: 82155162383     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2011.060293     Document Type: Article

References (37)

1. Ahmetov II, Hakimullina AM, Lyubaeva EV, Vinogradova OL & Rogozkin VA (2008). Effect ofHIF1Agene polymorphism on human muscle performance. Bull Exp Biol Med 146, 351-353.
2. Ahmetov II, Hakimullina AM, Popov DV, Lyubaeva EV, Missina SS, Vinogradova OL, Williams AG & Rogozkin VA (2009a). Association of theVEGFR2gene His472Gln polymorphism with endurance-related phenotypes. Eur J Appl Physiol 107, 95-103.
3. Ahmetov II, Mozhayskaya IA, Flavell DM, Astratenkova IV, Komkova AI, Lyubaeva EV, Tarakin PP, Shenkman BS, Vdovina AB, Netreba AI, Popov DV, Vinogradova OL, Montgomery HE & Rogozkin VA (2006). PPARα gene variation and physical performance in Russian athletes. Eur J Appl Physiol 97, 103-108.
4. Ahmetov II, Williams AG, Popov DV, Lyubaeva EV, Hakimullina AM, Fedotovskaya ON, Mozhayskaya IA, Vinogradova OL, Astratenkova IV, Montgomery HE & Rogozkin VA (2009b). The combined impact of metabolic gene polymorphisms on elite endurance athlete status and related phenotypes. Hum Genet 126, 751-761.
5. Andersen JL & Aagaard P (2000). Myosin heavy chain IIX overshoot in human skeletal muscle. Muscle Nerve 23, 1095-1104.
6. Andersen JL, Klitgaard H & Saltin B (1994). Myosin heavy chain isoforms in single fibres from m. vastus lateralis of sprinters: influence of training. Acta Physiol Scand 151, 135-142.
7. Andersen JL, Schjerling P & Saltin B (2000). Muscle, genes, and athletic performance. Sci Am 283, 48-55.
8. Arany Z (2008). PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev 18, 426-434.
9. Berman Y & North KN (2010). A gene for speed: the emerging role of α-actinin-3 in muscle metabolism. Physiology (Bethesda) 25, 250-259.
10. de Groot G, Hollander AP, Sargeant AJ, van Ingen Schenau GJ & de Boer RW (1987). Applied physiology of speed skating. J Sports Sci 5, 249-259.
11. de Koning JJ, Bakker FC, de Groot G & van Ingen Schenau GJ (1994). Longitudinal development of young talented speed skaters: physiological and anthropometric aspects. J Appl Physiol 77, 2311-2317.
12. de Koning JJ, de Groot G & van Ingen Schenau GJ (1992). A power equation for the sprint in speed skating. J Biomech 25, 573-580.
13. De Moor MH, Spector TD, Cherkas LF, Falchi M, Hottenga JJ, Boomsma DI & De Geus EJ (2007). Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet 10, 812-820.
14. Hettinga FJ, De Koning JJ, Schmidt LJ, Wind NA, Macintosh BR & Foster C (2011). Optimal pacing strategy: from theoretical modelling to reality in 1500-m speed skating. Br J Sports Med 45, 30-35.
15. Iazvikov VV, Morozov SA & Nekrasov AN (1988). Analysis of the composition of skeletal muscle fibers in skaters' muscles. Bull Exp Biol Med 105, 908-910.
16. Kanehisa H, Nemoto I, Okuyama H, Ikegawa S & Fukunaga T (1996). Force generation capacity of knee extensor muscles in speed skaters. Eur J Appl Physiol Occup Physiol 73, 544-551.
17. Klitgaard H, Mantoni M, Schiaffino S, Ausoni S, Gorza L, Laurent-Winter C, Schnohr P & Saltin B (1990). Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol Scand 140, 41-54.
18. Liu Y, Shen T, Randall WR & Schneider MF (2005). Signaling pathways in activity-dependent fiber type plasticity in adult skeletal muscle. J Muscle Res Cell Motil 26, 13-21.
19. MacArthur DG, Seto JT, Chan S, Quinlan KG, Raftery JM, Turner N, Nicholson MD, Kee AJ, Hardeman EC, Gunning PW, Cooney GJ, Head SI, Yang N & North KN (2008). AnActn3knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance. Hum Mol Genet 17, 1076-1086.
20. MacArthur DG, Seto JT, Raftery JM, Quinlan KG, Huttley GA, Hook JW, Lemckert FA, Kee AJ, Edwards MR, Berman Y, Hardeman EC, Gunning PW, Easteal S, Yang N & North KN (2007). Loss ofACTN3gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nat Genet 39, 1261-1265.
21. Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S & North K (2001). Differential expression of the actin-binding proteins, α-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet 10, 1335-1346.
22. Muehlbauer T, Panzer S & Schindler C (2010). Pacing pattern and speed skating performance in competitive long-distance events. J Strength Cond Res 24, 114-119.
23. Nemoto I, Iwaoka K, Funato K, Yoshioka N & Miyashita M (1988). Aerobic threshold, anaerobic threshold, and maximal oxygen uptake of Japanese speed-skaters. Int J Sports Med 9, 433-437.
24. Norman B, Esbjörnsson M, Rundqvist H, Osterlund T, von Walden F & Tesch PA (2009). Strength, power, fiber types, and mRNA expression in trained men and women with differentACTN3R577X genotypes. J Appl Physiol 106, 959-965.
25. Olson EN & Williams RS (2000). Remodeling muscles with calcineurin. BioEssays 22, 510-519.
26. Quinlan KG, Seto JT, Turner N, Vandebrouck A, Floetenmeyer M, Macarthur DG, Raftery JM, Lek M, Yang N, Parton RG, Cooney GJ & North KN (2010). α-Actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Hum Mol Genet 19, 1335-1346.
27. Ricoy JR, Encinas AR, Cabello A, Madero S & Arenas J (1998). Histochemical study of the vastus lateralis muscle fibre types of athletes. J Physiol Biochem 54, 41-47.
28. Schiaffino S (2010). Fibre types in skeletal muscle: a personal account. Acta Physiol (Oxf) 199, 451-463.
29. Simoneau J-A & Bouchard C (1995). Genetic determinism of fiber type proportion in human skeletal muscle. FASEB J 9, 1091-1095.
30. Simonides WS & van Hardeveld C (2008). Thyroid hormone as a determinant of metabolic and contractile phenotype of skeletal muscle. Thyroid 18, 205-216.
31. Sovak D & Hawes MR (1987). Anthropological status of international calibre speed skaters. J Sports Sci 5, 287-304.
32. Squire JM (1997). Architecture and function in the muscle sarcomere. Curr Opin Struct Biol 7, 247-257.
33. van Ingen Schenau GJ, de Koning JJ & de Groot G (1990). A simulation of speed skating performances based on a power equation. Med Sci Sports Exerc 22, 718-728.
34. Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P & Thomis MA (2007). ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics 32, 58-63.
35. Yang N, Garton F & North K (2009). α-Actinin-3 and performance. Med Sport Sci 54, 88-101.
36. Zawadowska B, Majerczak J, Semik D, Karasinski J, Kolodziejski L, Kilarski WM, Duda K & Zoladz JA (2004). Characteristics of myosin profile in human vastus lateralis muscle in relation to training background. Folia Histochem Cytobiol 42, 181-190.
37. Zhang B, Tanaka H, Shono N, Miura S, Kiyonaga A, Shindo M & Saku K (2003). The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet 63, 139-144.