Real-time, subsecond, multicomponent breath analysis by Optical Parametric Oscillator based Off-Axis Integrated Cavity Output Spectroscopy

Optics Express

Volumn 19, Issue 24, 2011, Pages 24078-24089

  Arslanov, Denis D ^a   Swinkels, Koen ^a   Cristescu, Simona M ^a   Harren, Frans J M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ETHANE; GAS DETECTORS; METHANE; OPTICAL PARAMETRIC OSCILLATORS;

BREATH ANALYSIS; CONTINUOUS WAVE; EXHALED BREATHS; GAS DETECTION; HIGH POTENTIAL; HIGH SENSITIVITY; HIGH TEMPORAL RESOLUTION; HUMAN BREATH; INTEGRATED CAVITY OUTPUT SPECTROSCOPIES; MEDICAL DIAGNOSTICS; MULTICOMPONENTS; NON-INVASIVE; OFF-AXIS; OUTPUT POWER; REAL-TIME DETECTION; SCANNING SPEED; SPECTRAL COVERAGE; TIME RESOLUTION; TRACE GAS DETECTION; WAVELENGTH RANGES;

SPECTRUM ANALYSIS;

ARTICLE; BREATH ANALYSIS; EQUIPMENT; EQUIPMENT DESIGN; HUMAN; INSTRUMENTATION; LASER; OSCILLOMETRY; REFRACTOMETRY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

BREATH TESTS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HUMANS; LASERS; OSCILLOMETRY; REFRACTOMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 82055206270     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.19.024078     Document Type: Article

References (34)

1. T. H. Risby and F. K. Tittel, "Current status of midinfrared quantum and interband cascade lasers for clinical breath analysis", Opt. Eng. 49(11), 111123 (2010).
2. W. Miekisch, J. K. Schubert, and G. F. E. Noeldge-Schomburg, "Diagnostic potential of breath analysis-focus on volatile organic compounds", Clin. Chim. Acta 347(1-2), 25-39 (2004).
3. T. H. Risby, "Volatile organic compounds as markers in normal and diseased states", in NATO ASI Series, Disease markers in exhaled breath: basic mechanisms and clinical applications, N. Marczin and M. H. Yacoub, eds. (IOS, 2002), pp. 113-122.
4. T. H. Risby and S. F. Solga, "Current status of clinical breath analysis", Appl. Phys. B 85(2-3), 421-426 (2006).
5. C. Wang and P. Sahay, "Breath Analysis Using Laser Spectroscopic Techniques Breath Biomarkers, Spectral Fingerprints, and Detection Limits", Sensors (Basel Switzerland) 9(10), 8230-8262 (2009).
6. B. Buszewski, M. Kesy, T. Ligor, and A. Amann, "Human exhaled air analytics: biomarkers of diseases", Biomed. Chromatogr. 21(6), 553-566 (2007).
7. A. Artlich, B. Jónsson, M. Bhiladvala, P. A. Lönnqvist, and L. E. Gustafsson, "Single breath analysis of endogenous nitric oxide in the newborn", Biol. Neonate 79(1), 21-26 (2001).
8. V. H. Tran, P. C. Hiang, M. Thurston, P. Jackson, C. Lewis, D. Yates, G. Bell, and P. S. Thomas, "Breath analysis of lung cancer patients using an electronic nose detection system", IEEE Sens. J. 10(9), 1514-1518 (2010).
9. G. Berden and R. Engeln, Cavity Ring-Down Spectroscopy: Techniques and Applications (Wiley, 2009).
10. S. M. Cristescu, S. T. Persijn, S. te Lintel Hekkert, and F. J. M. Harren, "Laser-based systems for trace gas detection in life sciences", Appl. Phys. B 92(3), 343-349 (2008).
11. R. Lewicki, J. H. Doty 3rd, R. F. Curl, F. K. Tittel, and G. Wysocki, "Ultrasensitive detection of nitric oxide at 5.33 μm by using external cavity quantum cascade laser-based Faraday rotation spectroscopy", Proc. Natl. Acad. Sci. U. S. A. 106(31), 12587-12592 (2009).
12. V. Spagnolo, A. A. Kosterev, L. Dong, R. Lewicki, and F. K. Tittel, "NO trace gas sensor based on quartzenhanced photoacoustic spectroscopy and external cavity quantum cascade laser", Appl. Phys. B 100(1), 125-130 (2010).
13. D. D. Arslanov, S. M. Cristescu, and F. J. M. Harren, "Optical parametric oscillator based off-axis integrated cavity output spectroscopy for rapid chemical sensing", Opt. Lett. 35(19), 3300-3302 (2010).
14. B. J. Orr and Y. He, "Rapidly swept continuous-wave cavity-ringdown spectroscopy", Chem. Phys. Lett. 512(1-3), 1-20 (2011).
15. 12C for carbon dioxide in human breath", Anal. Chem. 74(9), 2003-2007 (2002).
16. M. L. Silva, D. M. Sonnenfroh, D. I. Rosen, M. G. Allen, and A. O'Keefe, "Integrated cavity output spectroscopy measurements of NO levels in breath with a pulsed room-temperature QCL", Appl. Phys. B 81(5), 705-710 (2005).
17. J. Manne, O. Sukhorukov, W. Jäger, and J. Tulip, "Pulsed quantum cascade laser-based cavity ring-down spectroscopy for ammonia detection in breath", Appl. Opt. 45(36), 9230-9237 (2006).
18. I. Ventrillard-Courtillot, T. Gonthiez, C. Clerici, and D. Romanini, "Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy", J. Biomed. Opt. 14(6), 064026 (2009).
19. H. Dahnke, D. Kleine, P. Hering, and M. Murtz, "Real-time monitoring of ethane in human breath using midinfrared cavity leak-out spectroscopy", Appl. Phys. B 72, 971-975 (2001).
20. D. Halmer, S. Thelen, P. Hering, and M. Mürtz, "Online monitoring of ethane traces in exhaled breath with a difference frequency generation spectrometer", Appl. Phys. B 85(2-3), 437-443 (2006).
21. M. J. Thorpe, D. Balslev-Clausen, M. S. Kirchner, and J. Ye, "Cavity-enhanced optical frequency comb spectroscopy: application to human breath analysis", Opt. Express 16(4), 2387-2397 (2008).
22. J. H. Shorter, D. D. Nelson, J. B. McManus, M. S. Zahniser, S. R. Sama, and D. K. Milton, "Clinical study of multiple breath biomarkers of asthma and COPD (NO, CO2, CO and N2O) by infrared laser spectroscopy", J. Breath Res. 5(3), 037108 (2011).
23. G. N. Rao and A. Karpf, "External cavity tunable quantum cascade lasers and their applications to trace gas monitoring", Appl. Opt. 50(4), A100-A115 (2011).
24. K. R. Parameswaran, D. I. Rosen, M. G. Allen, A. M. Ganz, and T. H. Risby, "Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements", Appl. Opt. 48(4), B73-B79 (2009).
25. S. Persijn, F. Harren, and A. van der Veen, "Quantitative gas measurements using a versatile OPO-based cavity ringdown spectrometer and the comparison with spectroscopic databases", Appl. Phys. B 100(2), 383-390 (2010).
26. A. K. Y. Ngai, S. T. Persijn, G. von Basum, and F. J. M. Harren, "Automatically tunable continuous-wave optical parametric oscillator for high-resolution spectroscopy and sensitive trace-gas detection", Appl. Phys. B 85(2-3), 173-180 (2006).
27. J. B. Paul, L. Lapson, and J. G. Anderson, "Ultrasensitive absorption spectroscopy with a high-finesse optical cavity and off-axis alignment", Appl. Opt. 40(27), 4904-4910 (2001).
28. G. S. Engel, W. S. Drisdell, F. N. Keutsch, E. J. Moyer, and J. G. Anderson, "Ultrasensitive near-infrared integrated cavity output spectroscopy technique for detection of CO at 1.57 μm: new sensitivity limits for absorption measurements in passive optical cavities", Appl. Opt. 45(36), 9221-9229 (2006).
29. L. S. Rothman, I. E. Gordon, A. Barbe, D. Chris Benner, P. F. Bernath, M. Birk, V. Boudon, L. R. Brown, A. Campargue, J.-P. Champion, K. Chance, L. H. Coudert, V. Dana, V. M. Devi, S. Fally, J.-M. Flaud, R. R. Gamache, A. Goldman, D. Jacquemart, I. Kleiner, N. Lacome, W. J. Lafferty, J.-Y. Mandin, S. T. Massie, S. N. Mikhailenko, C. E. Miller, N. Moazzen-Ahmadi, O. V. Naumenko, A. V. Nikitin, J. Orphal, V. I. Perevalov, A. Perrin, A. Predoi-Cross, C. P. Rinsland, M. Rotger, M. Šimecková, M. A. H. Smith, K. Sung, S. A. Tashkun, J. Tennyson, R. A. Toth, A. C. Vandaele, and J. Vander Auwera, "The HITRAN 2008 molecular spectroscopic database", J. Quant. Spectrosc. Radiat. Transf. 110(9-10), 533-572 (2009).
30. 13C-labelled methane", Biogeochemistry 64(3), 355-372 (2003).
31. D. D. Arslanov, M. Spunei, A. K. Y. Ngai, S. M. Cristescu, I. D. Lindsay, S. T. Persijn, K. J. Boller, and F. J. M. Harren, "Rapid and sensitive trace gas detection with continuous wave optical parametric oscillator-based wavelength modulation spectroscopy", Appl. Phys. B 103(1), 223-228 (2011).
32. A. K. Y. Ngai, S. T. Persijn, I. D. Lindsay, A. A. Kosterev, P. Groß, C. J. Lee, S. M. Cristescu, F. K. Tittel, K.-J. Boller, and F. J. M. Harren, "Continuous wave optical parametric oscillator for quartz-enhanced photoacoustic trace gas sensing", Appl. Phys. B 89(1), 123-128 (2007).
33. S. W. Sharpe, T. J. Johnson, R. L. Sams, P. M. Chu, G. C. Rhoderick, and P. A. Johnson, "Gas-phase databases for quantitative infrared spectroscopy", Appl. Spectrosc. 58(12), 1452-1461 (2004).
34. J. King, A. Kupferthaler, K. Unterkofler, H. Koc, S. Teschl, G. Teschl, W. Miekisch, J. Schubert, H. Hinterhuber, and A. Amann, "Isoprene and acetone concentration profiles during exercise on an ergometer", J. Breath Res. 3(2), 027006 (2009).