An open trial of aripiprazole for the treatment of delirium in hospitalized cancer patients

Palliative and Supportive Care

Volumn 9, Issue 4, 2011, Pages 351-357

  Boettger, Soenke ^a   Breitbart, William ^b  

^a BELLEVUE HOSPITAL CENTER   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Antipsychotic treatment; Aripiprazole; Cancer; Delirium; Delirium subtypes

Indexed keywords

ARIPIPRAZOLE; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; QUINOLONE DERIVATIVE;

ADULT; AGED; ARTICLE; CLASSIFICATION; CLINICAL TRIAL; DELIRIUM; FEMALE; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGED; NEOPLASM; NONPARAMETRIC TEST; PROSPECTIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; DELIRIUM; FEMALE; HUMANS; INPATIENTS; MALE; MIDDLE AGED; NEOPLASMS; PIPERAZINES; PROSPECTIVE STUDIES; QUINOLONES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 82055172601     PISSN: 14789515     EISSN: 14789523     Source Type: Journal    
DOI: 10.1017/S1478951511000368     Document Type: Article

References (32)

1. Alao, A.O. & Moskowitz, L. (2006). Aripiprazole and delirium. Annals of Clinical Psychiatry, 18, 267-269.
2. Alao, A.O., Soderberg, M., Pohl, E.L., et al. (2005). Aripiprazole in the treatment of delirium. International Journal of Psychiatry in Medicine, 35, 429-433.
3. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association. 124-127.
4. Arnt, J. (1998). Pharmacological differentiation of classical and novel antipsychotics. International Clinical Psychopharmacology, 13, Suppl. 3, S7-14.
5. Boettger, S. & Breitbart,W. (2005). Atypical antipsychotics in the management of delirium: A review of the empirical literature. Palliative & Supportive Care, 3, 227-237.
6. Bond, S.M., Neelon, V.J. & Belyea, M.J. (2006). Delirium in hospitalized older patients with cancer. Oncology Nursing Forum, 33, 1075-1083.
7. Breitbart, W., Marotta, R., Platt, M.M., et al. (1996). A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. American Journal of Psychiatry, 153, 231-237.
8. Breitbart, W., Rosenfeld, B., Roth, A., et al. (1997). The memorial delirium assessment scale. Journal of Pain and Symptom Management, 13, 128-137.
9. Breitbart, W. & Strout, D. (2000). Delirium in the terminally ill. Clinics in Geriatric Medicine, 16, 357-372.
10. Breitbart, W., Tremblay, A. & Gibson, C. (2002). An open trial of olanzapine for the treatment of delirium in hospitalized cancer patients. Psychosomatics, 43, 175-182.
11. Bucht, G., Gustafson, Y. & Sandberg, O. (1999). Epidemiology of delirium. Dementia and Geriatric Cognitive Disorders, 10, 315-318.
12. DeLeon, A., Patel, N.C. & Crismon, M.L. (2004). Aripiprazole: A comprehensive review of its pharmacology, clinical efficacy, and tolerability. Clinical Therapeutics, 26, 649-666.
13. Factor, S.A. (2002). Pharmacology of atypical antipsychotics. Clinical Neuropharmacology, 25, 153-157.
14. Gagnon, B., Low, G. & Schreier, G. (2005). Methylphenidate hydrochloride improves cognitive function inpatients with advanced cancer and hypoactive delirium: A prospective clinical study. Journal of Psychiatry & Neuroscience, 30, 100-107.
15. Inouye, S.K. (1998). Delirium in hospitalized older patients. Clinics in Geriatric Medicine, 14, 745-764.
16. Kane, J.M. (2001). Extrapyramidal side effects are unacceptable. European Neuropsychopharmacology 11, Suppl. 4, S397-S403.
17. Karnofsky, D.A. Burchenal, J.H. (1949). The Clinical Evaluation of Chemotherapeutic Agents in Cancer. Evaluation of Chemotherapeutic Agents. New York: Columbia University Press. 191-205.
18. Lawlor, P.G., Nekolaichuk, C., Gagnon, B., et al. (2000). Clinical utility, factor analysis, and further validation of the memorial delirium assessment scale in patients with advanced cancer: Assessing delirium in advanced cancer. Cancer, 88, 2859-2867.
19. Lingjaerde, O., Ahlfors, U.G., Bech, P., et al. (1987). The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatrica Scandinavica Supplementum, 334, 1-100.
20. Lipowski, Z.J. (1989). Delirium in the elderly patient. New England Journal of Medicine, 320, 578-582.
21. Lonergan, E., Britton, A.M., Luxenberg, J., et al. (2007). Antipsychotics for delirium. Cochrane Database of Systematic Reviews, CD005594.
22. Massie, M.J., Holland, J. & Glass, E. (1983). Delirium in terminally ill cancer patients. American Journal of Psychiatry, 140, 1048-1050.
23. Meagher, D., Moran, M., Raju, B., et al. (2008a). A new data-based motor subtype schema for delirium. The Journal of Neuropsychiatry and Clinical Neurosciences, 20, 185-193.
24. Meagher, D.J., Moran, M., Raju, B., et al. (2008b). Motor symptoms in 100 patients with delirium versus control subjects: Comparison of subtyping methods. Psychosomatics, 49, 300-308.
25. Meagher, D.J., O'Hanlon, D., O'Mahony, E., et al. (2000). Relationship between symptoms and motoric subtype of delirium. The Journal of Neuropsychiatry and Clinical Neurosciences, 12, 51-56.
26. Miyamoto, S., Duncan, G.E., Marx, C.E., et al. (2004). Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs. Molecular Psychiatry, 10, 79-104.
27. Platt, M.M., Breitbart, W., Smith, M., et al. (1994). Efficacy of neuroleptics for hypoactive delirium. The Journal of Neuropsychiatry and Clinical Neurosciences, 6, 66-67.
28. Sommer, B.R.,Wise, L.C. & Kraemer, H.C. (2002). Is dopamine administration possibly a risk factor for delirium? Critical Care Medicine, 30, 1508-1511.
29. Straker, D.A., Shapiro, P.A. & Muskin, P.R. (2006). Aripiprazole in the treatment of delirium. Psychosomatics, 47, 385-391.
30. Taylor, D.M. (2003). Aripiprazole: A review of its pharmacology and clinical use. International Journal of Clinical Practice, 57, 49-54.
31. Trzepacz, P.T. (1999). Update on the neuropathogenesis of delirium. Dementia and Geriatric Cognitive Disorders, 10, 330-334.
32. Trzepacz, P.T., Breitbart, W., Franklin, J., et al. (1999). Practice guideline for the treatment of patients with delirium. American Psychiatric Association. American Journal of Psychiatry, 156, 1-20.