Childhood Intelligence and Midlife Inflammatory and Hemostatic Biomarkers: The National Child Development Study (1958) Cohort

Health Psychology

Volumn 30, Issue 6, 2011, Pages 710-718

  Calvin, Catherine M ^a   Batty, G David ^a,b,c   Lowe, Gordon D O ^d,e   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MRC SOCIAL AND PUBLIC HEALTH SCIENCES UNIT   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cardiovascular disease biomarkers; Cognitive ability; Hemostasis; Inflammation; Premorbid intelligence

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; D DIMER; FIBRINOGEN; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; ATTENUATION; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; CHILDHOOD INTELLIGENCE; CHILDHOOD INTELLIGENCE TEST SCORE; CLINICAL TRIAL; COGNITION; COHORT ANALYSIS; FEMALE; HEMOSTASIS; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INTELLIGENCE; INTELLIGENCE TEST; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; PROSPECTIVE STUDY; RECOGNITION; RISK FACTOR; SCHOOL CHILD; SCORING SYSTEM; SOCIAL STATUS; UNITED KINGDOM;

ADULT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHILD; CHILD DEVELOPMENT; COGNITION; COHORT STUDIES; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; GREAT BRITAIN; HUMANS; INFLAMMATION; INTELLIGENCE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; SOCIAL CLASS; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR;

EID: 82055172579     PISSN: 02786133     EISSN: 19307810     Source Type: Journal    
DOI: 10.1037/a0023940     Document Type: Article

References (65)

1. Ambrose J.A., Barua R.S. The pathophysiology of cigarette smoking and cardiovascular disease: An update. Journal of the American College of Cardiology 2004, 43:1731-1737. doi: 10.1016/j.jacc.2003.12.047.
2. Atherton K., Fuller E., Shepherd P., Strachan D.P., Power C. Loss and representativeness in a biomedical survey at age 45 years: 1958 British birth cohort. Journal of Epidemiology and Community Health 2008, 62:216-223. doi: 10.1136/jech.2006.058966.
3. Batlivala S.P. Focus on diagnosis: The erythrocyte sedimentation rate and the C-reactive protein test. Pediatrics in Review 2009, 30:72-74. doi: 10.1542/pir.30-2-72.
4. Batty G.D., Deary I.J., Macintyre S. Childhood IQ in relation to risk factors for premature mortality in middle-aged persons: The Aberdeen Children of the 1950s study. Journal of Epidemiology and Community Health 2007, 61:241-247. doi: 10.1136/jech.2006.048215.
5. Batty G.D., Deary I.J., Schoon I., Gale C.R. Childhood mental ability in relation to food intake and physical activity in adulthood: The 1970 British Cohort Study. Pediatrics 2007, 119:e35-e38. doi: 10.1542/peds.2006-1831.
6. Batty G.D., Deary I.J., Schoon I., Gale C.R. Mental ability across childhood in relation to risk factors for premature mortality in adult life: The 1970 British Cohort Study. Journal of Epidemiology and Community Health 2007, 61:997-1003. doi: 10.1136/jech.2006.054494.
7. Batty G.D., Gale C.R., Mortensen L.H., Langenberg C., Shipley M., Deary I.J. Pre-morbid IQ, the metabolic syndrome and mortality: The Vietnam Experience Study. Diabetologia 2008, 51:436-443. doi: 10.1007/s00125-007-0908-5.
8. Batty G.D., Mortensen E.L., Nybo Andersen A.-M., Osler M. Childhood intelligence in relation to adult coronary heart disease and stroke risk: Evidence from a Danish birth cohort study. Paediatric and Perinatal Epidemiology 2005, 19:429-452. doi: 10.1111/j.1365-3016.2005.00671.x.
9. Batty G.D., Shipley M.J., Mortensen L.H., Gale C.R., Deary I.J. IQ in late adolescence/early adulthood, risk factors in middle-age and later coronary heart disease mortality in men: The Vietnam Experience Study. European Journal of Cardiovascular Prevention & Rehabilitation 2008, 15:359-361. doi: 10.1097/HJR.0b013e3282f738a6.
10. Batty G.D., Wennerstad K.M., Davey Smith G., Gunnell D., Deary I.J., Tylenius P., Rasmussen F. IQ in early adulthood and mortality by middle age: Cohort study of one million Swedish men. Epidemiology 2009, 20:100-109. doi: 10.1097/EDE.0b013e31818ba076.
11. Chandola T., Deary I.J., Blane D., Batty G.D. Childhood IQ in relation to obesity and weight gain in adult life: The National Child Development (1958). Study. International Journal of Obesity 2006, 30:1422-1432. doi: 10.1038/sj.ijo.0803279.
12. Danesh J., Collins R., Appleby P., Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: Meta-analyses of prospective studies. The Journal of the American Medical Association 1998, 279:1477-1482. doi: 10.1001/jama.279.18.1477.
13. Danesh J., Whincup P., Walker M., Lennon L., Thomson A., Appleby P., Rumley A., Lowe G.D. Fibrin D-dimer and coronary heart disease: Prospective study and meta-analysis. Circulation 2001, 103:2323-2327. Retrieved from http://circ.ahajournals.org/cgi/content/full/103/19/2323.
14. Deary I.J. Why do intelligent people live longer?. Nature 2008, 13 November, 456:175-176. doi: 10.1038/456175a.
15. Deary I.J., Taylor M.D., Hart C.L., Wilson V., Davey Smith G., Blane D., Starr J.M. Intergenerational social mobility and mid-life status attainment: Influences of childhood intelligence, childhood social factors, and education. Intelligence 2005, 33:455-472. doi: 10.1016/j.intell.2005.06.003.
16. Deary I.J., Whiteman M.C., Starr J.M., Whalley L.J., Fox H.C. The impact of childhood intelligence on later life: Following up the Scottish Mental Surveys of 1932 and 1947. Journal of Personality and Social Psychology 2004, 86:130-147. doi: 10.1037/0022-3514.86.1.130.
17. Dehghan A., Kardys I., de Maat M.P.M., Uitterlinden A.G., Sijbrands E.J.G., Bootsma A.H., Witteman J.C.M. Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes 2007, 56:872-878. doi: 10.2337/db06-0922.
18. Der G., Batty G.D., Deary I.J. The association between IQ in adolescence and a range of health outcomes at 40 in the 1979 US National Longitudinal Study of Youth. Intelligence 2009, 37:573-580. doi: 10.1016/j.intell.2008.12.002.
19. Douglas J.W.B. The home and the school: A study of ability and attainment in the primary school 1964, MacGibbon & Kee, London, England.
20. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis. The Lancet 2010, 375:132-140. The Emerging Risk Factors Collaboration, doi: 10.1016/S0140-6736(09)61717-7.
21. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: Individual participant meta-analysis of 154,211 adults in 31 prospective studies. American Journal of Epidemiology 2007, 166:867-879. The Fibrinogen Studies Collaboration, doi: 10.1093/aje/kwm191.
22. Gale C.R., Deary I.J., Boyle S.H., Barefoot J., Mortensen L.H., Batty G.D. Cognitive ability in early adulthood and risk of 5 specific psychiatric disorders in middle life: The Vietnam Experience Study. Archives of General Psychiatry 2008, 65:1410-1418. Retrieved from http://archpsyc.ama-assn.org/cgi/content/full/65/12/1410.
23. Gallacher J., Bayer A., Lowe G., Fish M., Pickering J., Pedro S., Ben-Schlomo Y. Is sticky blood bad for the brain?: Hemostatic and inflammatory systems and dementia in the Caerphilly Prospective Study. Arteriosclerosis, Thrombosis, and Vascular Biology 2010, 30:599-604. doi: 10.1161/ATVBAHA.109.197368.
24. Gimeno D., Marmot M.G., Singh-Manoux A. Inflammatory markers and cognitive function in middle-aged adults: The Whitehall II study. Psychoneuroendocrinology 2008, 33:1322-1334. doi: 10.1016/j.psyneuen.2008.07.006.
25. Giugliano D., Ceriello A., Esposito K. The effects of diet on inflammation: Emphasis on the metabolic syndrome. Journal of the American College of Cardiology 2006, 48:677-685. doi: 10.1016/j.jacc.2006.03.052.
26. Hoth K.F., Haley A.P., Gunstad J., Paul R.H., Poppas A., Jefferson A.L., Cohen R.A. Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease. Journal of the American Geriatric Society 2008, 56:1898-1903.
27. Jokela M., Batty G.D., Deary I.J., Gale C.R., Kivimaki M. Low childhood IQ and early adult mortality: The role of explanatory factors in the 1958 British Birth Cohort. Pediatrics 2009, 124:e380-e388. doi: 10.1542/peds.2009-0334.
28. Jokela M., Elovainio M., Singh-Manoux A., Kivimaki M. IQ, socioeconomic status, and early death: The US National Longitudinal Survey of Youth. Psychosomatic Medicine 2009, 71:322-328. doi: 10.1097/PSY.0b013e31819b69f6.
29. Karlsson H., Ahlborg B., Dalman C., Hemmingsson T. Association between erythrocyte sedimentation rate and IQ in Swedish males aged 18-20. Brain, Behavior, and Immunity 2010, 24:868-873. doi: 10.1016/j.bbi.2010.02.009.
30. Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers: A systematic review. Journal of the American College of Cardiology 2005, 45:1563-1569. doi: 10.1016/j.jacc.2004.12.077.
31. Komulainen P., Lakka T.A., Kivipelto M., Hassinen M., Penttil I.L., Helkala E.-L., Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age and Ageing 2007, 36:443-448. doi: 10.1093/ageing/afm051.
32. Kuh D., Shah I., Richards M., Mishra G., Wadsworth M., Hardy R. Do childhood cognitive ability or smoking behaviour explain the influence of lifetime socio-economic conditions on premature adult mortality in a British post war birth cohort. Social Science and Medicine 2009, 68:1565-1573. doi: 10.1016/j.socscimed.2009.02.006.
33. Lang F.R., Weiss D., Stocker A., von Rosenbladt B. Assessing cognitive capacities in computer-assisted survey research: Two ultra-short tests of intellectual ability in the German socio-economic panel (SOEP). Schmollers Jahrbuch 2007, 127:183-192. Retrieved from http://schmollersjahrbuch.diw.de/schmollersjahrbuch/webcontent/2007/Lang%20et%20al.pdf.
34. Lawlor D.A., Batty G.D., Clark H., Macintyre S., Leon D.A. Association of childhood intelligence with risk of coronary heart disease and stroke: Findings from the Aberdeen Children of the 1950s cohort study. European Journal of Epidemiology 2008, 23:695-706. doi: 10.1007/s10654-008-9281-z.
35. Leonard B.E. Inflammation, depression and dementia: Are they connected?. Neurochemical Research 2007, 32:1749-1756. doi: 10.1007/s11064-007-9385-y.
36. Lewington S., Clarke R., Qizilbash N., Peto R., Collins R. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies. The Lancet 2002, 360:1903-1913. Prospective Studies Collaboration, doi: 10.1016/S0140-6736(02)11911-8.
37. Lowe G.D.O., Danesh J., Lewington S., Walker M., Lennon L., Thomson A., Whincup P.H. Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis. European Heart Journal 2004, 25:252-259. doi: 10.1016/j.ehj.2003.11.004.
38. Luciano M. Bio-marking the course of cognitive ability: Inflammatory marker effects in early adulthood, do they last?. Brain, Behavior, and Immunity 2010, 24:866-867. doi: 10.1016/j.bbi.2010.04.010.
39. Luciano M., Marioni R.E., Gow A.J., Starr J.M., Deary I.J. Reverse causation in the association between C-Reactive Protein and fibrinogen levels and cognitive abilities in an ageing sample. Psychosomatic Medicine 2009, 71:404-409. doi: 10.1097/PSY.0b013e3181a24fb9.
40. Marioni R.E., Deary I.J., Murray G.D., Lowe G.D.O., Rafnsson S.B., Strachan M.W.J., Price J.F. Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples. Behavior Genetics 2010, 40:3-11. doi: 10.1007/s10519-009-9302-z.
41. Marioni R.E., Strachan M.W., Reynolds R.M., Lowe G.D.O., Mitchell R.J., Fowkes F.G.R., Price J.F. Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Diabetes 2010, 59:710-713. doi: 10.2337/db09-1163.
42. O'Connor M., Bower J.E., Jin Cho H., Creswell J.D., Dimitrov S., Hamby M.E., Irwin M.R. To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity 2009, 23:887-897. doi: 10.1016/j.bbi.2009.04.005.
43. Pearson T.A., Mensah G.A., Alexander W., Anderson J.L., Cannon R.O., Criqui M., Vinicor F. Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003, 107:499-511. doi: 10.1161/01.CIR.0000052939.59093.45.
44. Pigeon D.A. Tests used in 1954 and 1957 surveys. The home and the school 1964, 121-132. Macgibbon & Kee, London, England, Appendix 1. J.W.B. Douglas (Ed.).
45. Plomin R., DeFries J.C., McClearn G.E., McGuffin P. Behavioral genetics 2007, Worth Publishers, New York, NY. 5th ed.
46. Power C., Elliot J. Cohort profile: 1958 British Birth Cohort (National Child Development study). International Journal of Epidemiology 2006, 35:34-41. doi: 10.1093/ije/dyi183.
47. Power C., Jeffries B.J., Manor O. Childhood cognition and risk factors for cardiovascular disease in midadulthood: The 1958 British Birth Cohort study. American Journal of Public Health 2010, 100:129-136. doi: 10.2105/AJPH.2008.155564.
48. Rafnsson S., Deary I.J., Whiteman M.C., Rumley A., Lowe G.D., Fowkes F.G. Haemorheological predictors of cognitive decline: The Edinburgh Artery Study. Age and Ageing 2010, 39:217-222. doi: 10.1093/ageing/afp227.
49. Richards M., Black S., Mishra G., Gale C.R., Deary I.J., Batty G.D. IQ in childhood and the metabolic syndrome in middle age: Extended follow-up of the 1946 British Birth Cohort Study. Intelligence 2009, 37:567-572. doi: 10.1016/j.intell.2008.09.004.
50. Ridker P.M. C-reactive protein: Eighty years from discovery to emergence as a major risk marker for cardiovascular disease. Clinical Chemistry 2009, 55:209-215. doi: 10.1373/clinchem.2008.119214.
51. Rudez G., Meijer P., Spronk H.M., Leebeek F.W., ten Cate H., Kluft C., de Maat M.P. Biological variation in inflammatory and hemostatic markers. Journal of Thrombosis and Haemostasis 2009, 7:1247-1255. doi: 10.1111/j.1538-7836.2009.03488.x.
52. Rudnicka A.R., Rumley A., Lowe G.D.O., Strachan D.P. Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von willebrand factor in a 45-year-old population. Circulation 2007, 115:996-1003. doi: 10.1161/CIRCULATIONAHA.106.635169.
53. Spiel A.O., Gilbert J.C., Jilma B. von Willebrand factor in cardiovascular disease: Focus on acute coronary syndromes. Circulation 2008, 117:1449-1459. doi: 10.1161/CIRCULATIONAHA.107.722827.
54. Starr J.M., Taylor M.D., Hart C.L., Davey Smith G., Whalley L.J., Hole D.J., Deary I.J. Childhood mental ability and blood pressure at midlife: Linking the Scottish Mental Survey 1932 and the Midspan studies. Journal of Hypertension 2004, 22:893-897. doi: 10.1097/01.hjh.0000098288.36684.8a.
55. Stott D.J., Robertson M., Rumley A., Welsh P., Sattar N., Packard C.J., Lowe G.D.O. Activation of hemostasis and decline in cognitive function in older people. Arteriosclerosis, Thrombosis, and Vascular Biology 2010, 30:605-611. doi: 10.1161/ATVBAHA.109.199448.
56. Su S., Snieder H., Miller A.H., Ritchie J., Bremner J.D., Goldberg J., Vaccarino V. Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis 2008, 200:213-220. doi: 10.1016/j.atherosclerosis.2007.12.009.
57. Tabassum F., Kumari M., Rumley A., Lowe G., Power C., Strachan D.P. Effects of socioeconomic position on inflammatory and hemostatic markers: A life-course analysis in the 1958 British Birth Cohort. American Journal of Epidemiology 2008, 167:1332-1341. doi: 10.1093/aje/kwn055.
58. Taylor M.D., Hart C.L., Davey Smith G., Starr J.M., Hole D.J., Whalley L.J., Deary I.J. Childhood mental ability and smoking cessation in adulthood: Prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies. Journal of Epidemiology and Community Health 2003, 57:464-465. doi: 10.1136/jech.57.6.464.
59. Teunissen C.E., van Boxtel M.P., Bosma H., Bosmans E., Delanghe J., De Bruijn C., de Vente J. Inflammation markers in relation to cognition in a healthy aging population. Journal of Neuroimmunology 2003, 134:142-150.
60. Tzoulaki I., Murray G.D., Price J.F., Smith F.B., Lee A.J., Rumley A., Fowkes F.G.R. Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: The Edinburgh Artery Study. American Journal of Epidemiology 2006, 163:334-341. doi: 10.1093/aje/kwj051.
61. NCDS 2008-9 guide to dataset first deposit 2010, U.K. Data Archive, Retrieved from http://www.data-archive.ac.uk/findingData/snDescription.asp?sn=6137#doc.
62. van Oijen M., Witteman J.C., Hofman A., Koudstaal P.J., Breteler M.M. Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia. Stroke 2005, 36:2637-2641. doi: 10.1161/01.STR.0000189721.31432.26.
63. Wennerstad K.M., Silventoinen K., Tynelius P., Bergman L., Rasmussen F. Association between intelligence and type specific stroke: A population-based cohort study of early fatal and non-fatal stroke in one million Swedish men. Journal of Epidemiology and Community Health 2010, 64:908-912. doi: 10.1136/jech.2008.084020.
64. Whalley L.J., Deary I.J. Longitudinal cohort study of childhood IQ and survival up to age 76. British Medical Journal 2001, 322:819-822. doi: 10.1136/bmj.322.7290.819.
65. Woodward M., Rumley A., Welsh P., MacMahon S., Lowe G. A comparison of the associations between seven hemostatic or inflammatory variables and coronary heart disease. Journal of Thrombosis and Haemostasis 2007, 5:1795-1800. doi: 10.1111/j.1538-7836.2007.02677.x.