Levetiracetam in primary orthostatic tremor: A double-blind placebo-controlled crossover study

Movement Disorders

Volumn 26, Issue 13, 2011, Pages 2431-2434

  Hellriegel, Helge ^a   Raethjen, Jan ^a   Deuschl, G ^a   Volkmann, Jens ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Clinical neurology; Clinical trials; Levetiracetam; Orthostatic tremor

Indexed keywords

ETIRACETAM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; FATIGUE; FEMALE; HUMAN; MALE; NAUSEA; ORTHOSTATIC STRESS; PRIORITY JOURNAL; SHORT FORM 36; TREMOR; VISUAL ANALOG SCALE;

AGED; AGED, 80 AND OVER; ANTICONVULSANTS; CROSS-OVER STUDIES; DIZZINESS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PIRACETAM; PLACEBOS; TREATMENT OUTCOME; TREMOR;

EID: 81955164827     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23881     Document Type: Article

References (17)

1. Heilman KM. Orthostatic tremor. Arch Neurol 1984; 41: 880-881.
2. Deuschl G, Bain P, Brin M. Consensus statement of the Movement Disorder Society on Tremor. Ad Hoc Scientific Committee. Mov Disord 1998; 13( Suppl 3): 2-23.
3. Rodrigues JP, Edwards DJ, Walters SE, et al. Blinded placebo crossover study of gabapentin in primary orthostatic tremor. Mov Disord 2006; 21: 900-905.
4. Koster B, Lauk M, Timmer J, et al. Involvement of cranial muscles and high intermuscular coherence in orthostatic tremor. Ann Neurol 1999; 45: 384-388.
5. Wills AJ, Brusa L, Wang HC, Brown P, Marsden CD. Levodopa may improve orthostatic tremor: case report and trial of treatment. J Neurol Neurosurg Psychiatry 1999; 66: 681-684.
6. Finkel MF. Pramipexole is a possible effective treatment for primary orthostatic tremor (shaky leg syndrome). Arch Neurol 2000; 57: 1519-1520.
7. Espay AJ, Duker AP, Chen R, et al. Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations. Mov Disord 2008; 23: 2357-2362.
8. Guridi J, Rodriguez-Oroz MC, Arbizu J, et al. Successful thalamic deep brain stimulation for orthostatic tremor. Mov Disord 2008; 23: 1808-1811.
9. Striano P, Elefante A, Coppola A, et al. Dramatic response to levetiracetam in post-ischaemic Holmes' tremor. J Neurol Neurosurg Psychiatry 2007; 78: 438-439.
10. Feys P, D'Hooghe MB, Nagels G, Helsen WF. The effect of levetiracetam on tremor severity and functionality in patients with multiple sclerosis. Mult Scler 2009; 15: 371-378.
11. Ondo WG, Jimenez JE, Vuong KD, Jankovic J. An open-label pilot study of levetiracetam for essential tremor. Clin Neuropharmacol 2004; 27: 274-277.
12. Elble RJ, Lyons KE, Pahwa R. Levetiracetam is not effective for essential tremor. Clin Neuropharmacol 2007; 30: 350-356.
13. Angehagen M, Margineanu DG, Ben-Menachem E, Ronnback L, Hansson E, Klitgaard H. Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons. Neuroreport 2003; 14: 471-475.
14. Lauk M, Timmer J, Lucking CH, Honerkamp J, Deuschl G. A software for recording and analysis of human tremor. Comput Methods Programs Biomed 1999; 60: 65-77.
15. Thompson PD, Rothwell JC, Day BL, et al. The physiology of orthostatic tremor. Arch Neurol 1986; 43: 584-587.
16. Fung VS, Sauner D, Day BL. A dissociation between subjective and objective unsteadiness in primary orthostatic tremor. Brain 2001; 124: 322-330.
17. Britton TC, Thompson PD, van der Kamp W, et al. Primary orthostatic tremor: further observations in six cases. J Neurol 1992; 239: 209-217.