Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with a focal amplification at chromosome 19q13.42 locus: Further evidence of two new instances in China

Neuropathology

Volumn 31, Issue 6, 2011, Pages 639-647

  Wang, Yin ^a   Chu, Shu Guang ^a   Xiong, Ji ^a   Cheng, Hai Xia ^a   Chen, Hong ^a   Yao, Xiao Hong ^b  

^a FUDAN UNIVERSITY   (China)

^b XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Chromosome 19q13.42; Embryonal tumor with abundant neuropil and true rosettes; Embryonal tumor with multilayered rosettes; Ependymoblastic rosette; Ependymoblastoma

Indexed keywords

BETA CATENIN; EPITHELIAL MEMBRANE ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; PROTEIN P53;

ADULT; ARTICLE; BALANCE DISORDER; BLOOD ANALYSIS; CANCER ADJUVANT THERAPY; CANCER SURGERY; CASE REPORT; CELL EXPANSION; CELL STRAIN; CENTRAL NERVOUS SYSTEM; CHILD; CHINA; CHROMOSOME 19Q; CHROMOSOME 2; CRANIAL NERVE PARALYSIS; CRANIOTOMY; DIFFUSION WEIGHTED IMAGING; EMBRYONAL CARCINOMA; EPENDYMOBLASTOMA; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GAIT DISORDER; GENE LOCUS; HEADACHE; HEMIPLEGIA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; MALE; NAUSEA AND VOMITING; NEUROLOGIC EXAMINATION; NEUROPIL; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PAPILLARY CARCINOMA; PARIETAL LOBE; PONTINE TUMOR; PRESCHOOL CHILD; PRIORITY JOURNAL; ROSETTE FORMATION; SMALL CELL CARCINOMA; STRABISMUS; THORAX RADIOGRAPHY; TUMOR CELL; VISUAL DISORDER; WORLD HEALTH ORGANIZATION;

BRAIN NEOPLASMS; CHILD, PRESCHOOL; CHINA; CHROMOSOMES, HUMAN, PAIR 19; GENE AMPLIFICATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; NEUROPIL;

EID: 81955161242     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2011.01215.x     Document Type: Article

References (29)

1. Li M, Lee KF, Lu Y etal. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. Cancer Cell 2009; 16: 533-546.
2. Pfister SM, Remke M, Castoldi M etal. Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 2009; 117: 457-464.
3. Eberhart CG, Brat DJ, Cohen KJ, Burger PC. Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 2000; 3: 346-352.
4. Gessi M, Giangaspero F, Lauriola L etal. Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 2009; 33: 211-217.
5. Al-Hussain TO, Dababo MA. Posterior fossa tumor in a 2 year-old girl. Brain Pathol 2009; 19: 343-346.
6. Buccoliero AM, Castiglione F, Degl'innocenti DR etal. Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. Neuropathology 2010; 30: 84-91.
7. Dunham C, Sugo E, Tobias V, Wills E, Perry A. Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation. J Neurooncol 2007; 84: 91-98.
8. Ferri Ñiguez B, Martínez-Lage JF, Almagro MJ etal. Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update. Childs Nerv Syst 2010; 26: 1003-1008.
9. Fuller C, Fouladi M, Gajjar A, Dalton J, Sanford R, Helton K. Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes. Am J Clin Pathol 2006; 126: 277-283.
10. La Spina M, Pizzolitto S, Skrap M etal. Embryonal tumor with abundant neuropil and true rosettes. A new entity or only variations of a parent neoplasms (PNETs)? This is the dilemma. J Neurooncol 2006; 78: 317-320.
11. Lim I, Mikolaenko I, Cohen M. A 3-year-old girl with altered mental status, gait difficulty, and vomiting. Brain Pathol 2011; 21: 105-108.
12. Manjila S, Ray A, Hu Y, Cai DX, Cohen ML, Cohen AR. Embryonal tumors with abundant neuropil and true rosettes: 2 illustrative cases and a review of the literature. Neurosurg Focus 2011; 30: E2.
13. McLendon RE, Judkins AR, Eberhart CG, Fuller GN, Sarkar C, Ng HK. Central nervous system primitive neuroectodermal tumours. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System, 4th edn. Lyon: IARC Press, 2007; 141-146.
14. Bailey P, Cusing H. A Classification of the Tumors of the Glioma Group on A Histogenetic Basis with A Correlated Study of Prognosis. Philadelphia, PA: J.B. Lippincott Co, 1926.
15. Cruz-Sanchez FF, Haustein J, Rossi ML, Cervos-Navarro J, Hughes JT. Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. Histopathology 1988; 12: 17-27.
16. Cruz-Sanchez FF, Rossi ML, Hughes JT, Moss TH. Differentiation in embryonal neuroepithelial tumors of the central nervous system. Cancer 1991; 67: 965-976.
17. Mork SJ, Rubinstein LJ. Ependymoblastoma: a reappraisal of a rare embryonal tumor. Cancer 1985; 55: 1536-1542.
18. Judkins A, Ellison D. Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. Brain Pathol 2010; 20: 133-139.
19. Korshunov A, Remke M, Gessi M etal. Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 2010; 120: 253-260.
20. Paulus W, Kleihues P. Genetic profiling of CNS tumors extends histological classification. Acta Neuropathol 2010; 120: 269-270.
21. Queiroz LS, de Faria JL, Cruz Neto JN. An ependymoblastoma of the pons. J Pathol 1975; 115: 207-210.
22. Yagashita SIY, Chiba Y, Yuda K. Cerebral neuroblastoma. J Pathol Anat Histol 1978; 381: 1-11.
23. Burger PC, Yu IT, Tihan T etal. Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. Am J Surg Pathol 1998; 22: 1083-1092.
24. Laurent L, Chen J, Ulitsky I etal. Comprehensive MicroRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells 2008; 26: 1506-1516.
25. Eberhart CG. Molecular diagnostics in embryonal brain tumors. Brain Pathol 2011; 21: 96-104.
26. Pfister SM, Korshunov A, Kool M etal. Molecular diagnostics of CNS embryonal tumors. Acta Neuropathol 2010; 120: 553-566.
27. Rickert C, Hasselblatt M. Cytogenetic features of ependymoblastomas. Acta Neuropathol 2006; 111: 559-562.
28. Gessi M, Pfister S, Hans VH, Korshunov A, Pietsch T. Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation. Acta Neuropathol 2011; 121: 283-285.
29. Gessi M, Muehlen AZ, Lauriola L, Gardiman MP, Giangaspero F, Pietsch T. TP53, β-Catenin and c-myc/N-myc status in embryonal tumours with ependymoblastic rosettes. Neuropathol Appl Neurobiol 2010. Epub ahead of print: doi:10.1111/j.1365-2990.2010.01151.x.