Genetic profiling of CNS tumors extends histological classification

Acta Neuropathologica

Volumn 120, Issue 2, 2010, Pages 269-270

  Paulus, Werner ^a   Kleihues, Paul ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MICRORNA; PROTEIN IDH1; PROTEIN IDH2; PROTEIN P53; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ASTROCYTOMA; CENTRAL NERVOUS SYSTEM TUMOR; CHROMOSOME 19Q; CHROMOSOME ABERRATION; EMBRYONAL TUMOR WITH ABUNDANT NEUROPIL AND TRUE ROSETTES; EPENDYMOBLASTOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE MUTATION; GLIOBLASTOMA; GLIOMATOSIS CEREBRI; HISTOPATHOLOGY; HUMAN; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOID TUMOR; TERATOMA; TUMOR CLASSIFICATION; WORLD HEALTH ORGANIZATION; CLASSIFICATION; GENETICS; PATHOLOGY;

CENTRAL NERVOUS SYSTEM NEOPLASMS; HUMANS;

EID: 77957271260     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0710-1     Document Type: Note

References (9)

1. Antonelli M, Buttarelli FR, Arcella A et al (2010) Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas. J Neuro Oncol (in press). doi:10.1007/s11060-010-0129-5
2. Eberhart CG, Brat DJ, Cohen KJ, Burger PC (2000) Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 3: 346-352
3. Gessi M, Giangaspero F, Lauriola L et al (2009) Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 33: 211-217
4. Judkins AR, Ellison DW (2010) Ependymoblastoma: dear, damned, distracting diagnosis, farewell!. Brain Pathol 20: 133-139
5. Korshunov A, Remke M, Gessi M et al (2010) Focal genomic amplification at 19q 13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol (this issue), doi: 10.1007/s00401-010-0688-8
6. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) WHO classification of tumours of the central nervous system, 4th edn. International Agency for Research on Cancer, Lyon
7. Nobusawa S, Watanabe T, Kleihues P, Ohgaki H (2009) IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res 15: 6002-6007
8. Pfister S, Remke M, Castoldi M et al (2009) Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 117: 457-464
9. Seiz M. Tuettenberg J, Meyer J et al (2010) Detection of IDH1 mutations in gliomatosis cerebri, but only in tumors with additional solid component: evidence for molecular subtypes. Acta Neuropathol (this issue), doi : 10.1007/s00401-010-0701-2