Genome-wide association study identifies breast cancer risk variant at 10q21.2: Results from the asia breast cancer consortium

Human Molecular Genetics

Volumn 20, Issue 24, 2011, Pages 4991-4999

  Cai, Qiuyin ^a   Long, Jirong ^a   Lu, Wei ^c   Qu, Shimian ^a   Wen, Wanqing ^a   Kang, Daehee ^d   Lee, Ji Young ^d   Chen, Kexin ^e   Shen, Hongbing ^f   Shen, Chen Yang ^g   Sung, Hyuna ^d   Matsuo, Keitaro ^h   Haiman, Christopher A ⁱ   Khoo, Ui Soon ^j   Ren, Zefang ^k   Iwasaki, Motoki ^l   Gu, Kai ^c   Xiang, Yong Bing ^m   Choi, Ji Yeob ^d   Park, Sue K ^d   Zhang, Lina ^e   Hu, Zhibin ^f   Wu, Pei Ei ^g   Noh, Dong Young ^d   Tajima, Kazuo ^h   Henderson, Brian E ⁱ   Chan, Kelvin Y K ^j   Su, Fengxi ^k   Kasuga, Yoshio ⁿ   Wang, Wenjing ^c   Cheng, Jia Rong ^m   Yoo, Keun Young ^d   Lee, Jong Young ^o   Zheng, Hong ^e   Liu, Yao ^f   Shieh, Ya Lan ^g   Kim, Sung Won ^p   Lee, Jong Won ^q   Iwata, Hiroji ^h   Marchand, Loic Le ^r   Chan, Sum Yin ^j   Xie, Xiaoming ^k   Tsugane, Shoichiro ^l   Lee, Min Hyuk ^s   Wang, Shenming ^k   Li, Guoliang ^a   Levy, Shawn ^t   Huang, Bo ^a   Shi, Jiajun ^a   Delahanty, Ryan ^a   Zheng, Ying ^c   Li, Chun ^b   Gao, Yu Tang ^m   Shu, Xiao Ou ^a   Zheng, Wei ^a   more..

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Shanghai Municipal Center for Disease Control and Prevention   (China)

^d Seoul National University College of Medicine   (South Korea)

^e TIANJIN MEDICAL UNIVERSITY   (China)

^f NANJING MEDICAL UNIVERSITY   (China)

^g INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^h AICHI CANCER CENTER HOSPITAL   (Japan)

ⁱ UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^j UNIVERSITY OF HONG KONG   (Hong Kong)

^k SUN YAT SEN UNIVERSITY   (China)

^l NATIONAL CANCER CENTER   (Japan)

^m SHANGHAI CANCER INSTITUTE   (China)

ⁿ Nagano Matsushiro General Hospital   (Japan)

^o Korea National Institute of Health   (South Korea)

^p Seoul National University Bundang Hospital   (South Korea)

^q University of Ulsan College of Medicine   (South Korea)

^r UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^s Soonchunhyang University College of Medicine   (South Korea)

^t HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 365;

ADULT; AGED; ALLELE; ARTICLE; ASIA; ASIAN; BREAST CANCER; CANCER RISK; CHINESE; CHROMOSOME 10Q; CONTROLLED STUDY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; JAPANESE; KOREAN; MAJOR CLINICAL STUDY; MENOPAUSE; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ALLELES; ASIA; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MENOPAUSE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 81855226435     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr405     Document Type: Article

References (42)

1. Nathanson, K.L., Wooster, R. and Weber, B.L. (2001) Breast cancer genetics: what we know and what we need. Nat. Med., 7, 552-556.
2. Balmain, A., Gray, J. and Ponder, B. (2003) The genetics and genomics of cancer. Nat. Genet., 33 (suppl.), 238-244.
3. Easton, D.F., Pooley, K.A., Dunning, A.M., Pharoah, P.D., Thompson, D., Ballinger, D.G., Struewing, J.P., Morrison, J., Field, H., Luben, R. et al. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, 1087-1093.
4. Hunter, D.J., Kraft, P., Jacobs, K.B., Cox, D.G., Yeager, M., Hankinson, S.E., Wacholder, S., Wang, Z., Welch, R., Hutchinson, A. et al. (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet., 39, 870-874.
5. Stacey, S.N., Manolescu, A., Sulem, P., Thorlacius, S., Gudjonsson, S.A., Jonsson, G.F., Jakobsdottir, M., Bergthorsson, J.T., Gudmundsson, J., Aben, K.K. et al. (2008) Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat. Genet., 40, 703-706.
6. Gold, B., Kirchhoff, T., Stefanov, S., Lautenberger, J., Viale, A., Garber, J., Friedman, E., Narod, S., Olshen, A.B., Gregersen, P. et al. (2008) Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc. Natl Acad. Sci. USA, 105, 4340-4345.
7. Zheng, W., Long, J., Gao, Y.T., Li, C., Zheng, Y., Xiang, Y.B., Wen, W., Levy, S., Deming, S.L., Haines, J.L. et al. (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat. Genet., 41, 324-328.
8. Thomas, G., Jacobs, K.B., Kraft, P., Yeager, M., Wacholder, S., Cox, D.G., Hankinson, S.E., Hutchinson, A., Wang, Z., Yu, K. et al. (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat. Genet., 41, 579-584.
9. Ahmed, S., Thomas, G., Ghoussaini, M., Healey, C.S., Humphreys, M.K., Platte, R., Morrison, J., Maranian, M., Pooley, K.A., Luben, R. et al. (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat. Genet., 41, 585-590.
10. Stacey, S.N., Manolescu, A., Sulem, P., Rafnar, T., Gudmundsson, J., Gudjonsson, S.A., Masson, G., Jakobsdottir, M., Thorlacius, S., Helgason, A. et al. (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat. Genet., 39, 865-869.
11. Long, J., Cai, Q., Shu, X.O., Qu, S., Li, C., Zheng, Y., Gu, K., Wang, W., Xiang, Y.B., Cheng, J. et al. (2010) Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet., 6, e1001002.
12. Turnbull, C., Ahmed, S., Morrison, J., Pernet, D., Renwick, A., Maranian, M., Seal, S., Ghoussaini, M., Hines, S., Healey, C.S. et al. (2010) Genome-wide association study identifies five new breast cancer susceptibility loci. Nat. Genet., 42, 504-507.
13. Antoniou, A.C., Wang, X., Fredericksen, Z.S., McGuffog, L., Tarrell, R., Sinilnikova, O.M., Healey, S., Morrison, J., Kartsonaki, C., Lesnick, T. et al. (2010) A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat. Genet., 42, 885-892.
14. Fletcher, O., Johnson, N., Orr, N., Hosking, F.J., Gibson, L.J., Walker, K., Zelenika, D., Gut, I., Heath, S., Palles, C. et al. (2011) Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. J. Natl Cancer Inst., 103, 425-435.
15. Gaudet, M.M., Kirchhoff, T., Green, T., Vijai, J., Korn, J.M., Guiducci, C., Segre, A.V., McGee, K., McGuffog, L., Kartsonaki, C. et al. (2010) Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet., 6, e1001183.
16. Zhang, B., Beeghly-Fadiel, A., Long, J. and Zheng, W. (2011) Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol., 12, 477-488.
17. Long, J., Shu, X.O., Cai, Q., Gao, Y.T., Zheng, Y., Li, G., Li, C., Gu, K., Wen, W., Xiang, Y.B. et al. (2010) Evaluation of breast cancer susceptibility loci in Chinese women. Cancer Epidemiol. Biomarkers Prev., 19, 2357-2365.
18. Zheng, W., Wen, W., Gao, Y.T., Shyr, Y., Zheng, Y., Long, J., Li, G., Li, C., Gu, K., Cai, Q. et al. (2010) Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women. J. Natl Cancer Inst., 102, 972-981.
19. Wang, Q., Du, X., Meinkoth, J., Hirohashi, Y., Zhang, H., Liu, Q., Richter, M. and Greene, M.I. (2006) Characterization of Su48, a centrosome protein essential for cell division. Proc. Natl Acad. Sci. USA, 103, 6512-6517.
20. Gianfrancesco, F., Esposito, T., Ombra, M.N., Forabosco, P., Maninchedda, G., Fattorini, M., Casula, S., Vaccargiu, S., Casu, G., Cardia, F. et al. (2003) Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. Am. J. Hum. Genet., 72, 1479-1491.
21. Berberat, P.O., Katori, M., Kaczmarek, E., Anselmo, D., Lassman, C., Ke, B., Shen, X., Busuttil, R.W., Yamashita, K., Csizmadia, E. et al. (2003) Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury. FASEB J., 17, 1724-1726.
22. Epsztejn, S., Glickstein, H., Picard, V., Slotki, I.N., Breuer, W., Beaumont, C. and Cabantchik, Z.I. (1999) H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties. Blood, 94, 3593-3603.
23. Shpyleva, S.I., Tryndyak, V.P., Kovalchuk, O., Starlard-Davenport, A., Chekhun, V.F., Beland, F.A. and Pogribny, I.P. (2011) Role of ferritin alterations in human breast cancer cells. Breast Cancer Res. Treat., 126, 63-71.
24. Wu, X., Lee, V.C., Chevalier, E. and Hwang, S.T. (2009) Chemokine receptors as targets for cancer therapy. Curr. Pharm. Des., 15, 742-757.
25. Mburu, Y.K., Wang, J., Wood, M.A., Walker, W.H. and Ferris, R.L. (2006) CCR7 mediates inflammation-associated tumor progression. Immunol. Res., 36, 61-72.
26. Yu, J.W. and Shi, Y. (2008) FLIP and the death effector domain family. Oncogene, 27, 6216-6227.
27. Safa, A.R., Day, T.W. and Wu, C.H. (2008) Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr. Cancer Drug Targets, 8, 37-46.
28. Gao, Y.T., Shu, X.O., Dai, Q., Potter, J.D., Brinton, L.A., Wen, W., Sellers, T.A., Kushi, L.H., Ruan, Z., Bostick, R.M. et al. (2000) Association of menstrual and reproductive factors with breast cancer risk: results from the Shanghai Breast Cancer Study. Int. J. Cancer, 87, 295-300.
29. Zhang, L., Gu, L., Qian, B., Hao, X., Zhang, W., Wei, Q. and Chen, K. (2009) Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women. Breast Cancer Res. Treat., 114, 327-338.
30. Liang, J., Chen, P., Hu, Z., Zhou, X., Chen, L., Li, M., Wang, Y., Tang, J., Wang, H. and Shen, H. (2008) Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis, 29, 2341-2346.
31. Wang, Y., Hu, Z., Liang, J., Wang, Z., Tang, J., Wang, S., Wang, X., Qin, J., Wang, X. and Shen, H. (2008) A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women. Carcinogenesis, 29, 1197-1201.
32. Ding, S.L., Yu, J.C., Chen, S.T., Hsu, G.C., Kuo, S.J., Lin, Y.H., Wu, P.E. and Shen, C.Y. (2009) Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Carcinogenesis, 30, 43-49.
33. Hsu, H.M., Wang, H.C., Chen, S.T., Hsu, G.C., Shen, C.Y. and Yu, J.C. (2007) Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Cancer Epidemiol. Biomarkers Prev., 16, 2024-2032.
34. Chan, K.Y., Liu, W., Long, J.R., Yip, S.P., Chan, S.Y., Shu, X.O., Chua, D.T., Cheung, A.N., Ching, J.C., Cai, H. et al. (2009) Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women. J. Med. Genet., 46, 32-39.
35. Hamajima, N., Matsuo, K., Saito, T., Hirose, K., Inoue, M., Takezaki, T., Kuroishi, T. and Tajima, K. (2001) Gene-environment interactions and polymorphism studies of cancer risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). Asian Pac. J. Cancer Prev., 2, 99-107.
36. Haiman, C.A., Garcia, R.R., Hsu, C., Xia, L., Ha, H., Sheng, X., Le, M.L., Kolonel, L.N., Henderson, B.E., Stallcup, M.R. et al. (2009) Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. BMC Cancer, 9, 43.
37. Kolonel, L.N., Henderson, B.E., Hankin, J.H., Nomura, A.M., Wilkens, L.R., Pike, M.C., Stram, D.O., Monroe, K.R., Earle, M.E. and Nagamine, F.S. (2000) A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am. J. Epidemiol., 151, 346-357.
38. Itoh, H., Iwasaki, M., Hanaoka, T., Kasuga, Y., Yokoyama, S., Onuma, H., Nishimura, H., Kusama, R. and Tsugane, S. (2009) Serum organochlorines and breast cancer risk in Japanese women: a case-control study. Cancer Causes Control, 20, 567-580.
39. Choi, J.Y., Lee, K.M., Park, S.K., Noh, D.Y., Ahn, S.H., Yoo, K.Y. and Kang, D. (2005) Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer, 5, 143.
40. Lee, K.M., Choi, J.Y., Park, S.K., Chung, H.W., Ahn, B., Yoo, K.Y., Han, W., Noh, D.Y., Ahn, S.H., Kim, H. et al. (2005) Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. Cancer Epidemiol. Biomarkers Prev., 14, 821-825.
41. Han, S.A., Park, S.K., Hyun, A.S., Hyuk, L.M., Noh, D.Y., Kim, L.S., Noh, W.C., Jung, Y., Sang, K.K. and Kim, S.W., Korean Breast Cancer Study Group (2011) The Korean Hereditary Breast Cancer (KOHBRA) Study: protocols and interim report. Clin. Oncol. (R. Coll. Radiol.), 23, 434-441.
42. Cho, Y.S., Go, M.J., Kim, Y.J., Heo, J.Y., Oh, J.H., Ban, H.J., Yoon, D., Lee, M.H., Kim, D.J., Park, M. et al. (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet., 41, 527-534.