Poor responders to controlled ovarian hyperstimulation for in vitro fertilisation (IVF)

Human Fertility

Volumn 14, Issue 4, 2011, Pages 230-245

  Kamble, Lata ^a   Gudi, Anil ^a   Shah, Amit ^a   Homburg, Roy ^a  

^a HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Assisted conception; GnRH antagonist; Gonadotrophin releasing hormone (GnRH) agonist; Gonadotrophins; Growth hormone; in vitro fertilisation (IVF); Letrozole; Low responders; Natural cycle.; Poor responders; Testosterone

Indexed keywords

ACETYLSALICYLIC ACID; ARGININE; BIOCHEMICAL MARKER; CLOMIFENE CITRATE; ESTROGEN; FOLLITROPIN RECEPTOR; GESTAGEN; GONADOTROPIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LETROZOLE; LEUPRORELIN; LUTEINIZING HORMONE; ORAL CONTRACEPTIVE AGENT; PRASTERONE; PYRIDOSTIGMINE; RECOMBINANT FOLLITROPIN; TESTOSTERONE;

ARTICLE; CONGENITAL MALFORMATION; DNA POLYMORPHISM; DRUG MEGADOSE; FERTILIZATION IN VITRO; HEART DISEASE; HUMAN; LOW DRUG DOSE; LUTEAL PHASE; LUTEOLYSIS; MULTIPLE CYCLE TREATMENT; OVARIAN RESERVE; OVARY HYPERSTIMULATION; RANDOMIZED CONTROLLED TRIAL;

ADULT; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; OVULATION INDUCTION;

EID: 81855226180     PISSN: 14647273     EISSN: 17428149     Source Type: Journal    
DOI: 10.3109/14647273.2011.608241     Document Type: Article

References (139)

1. Akman M. A., Erden H. F., Tosun S. B., Bayazit N., Aksoy E., & Bahceci, M.2001). Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Human reproduction (Oxford, England), 16, 868-870. (Pubitemid 32451819)
2. Al-Inany H., Aboulghar M. A., Mansour R. T., & Serour, G. I.(2005). Ovulation induction in the new millennium: recombinant follicle-stimulating hormone versus human menopausal gonadotropin. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology, 20, 161-169. (Pubitemid 40694922)
3. Anserini P., Magnasco A., Remorgida V., Gaggero G., Testa D., & Capitanio, G. L.1997). Comparison of a blocking vs. a flareup protocol in poor responders with a normal and abnormal clomiphene citrate challenge test. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology, 11, 321-326. (Pubitemid 27482862)
4. Anteby, E. Y., Hurwitz, A., Korach, O., Revel, A., Simon, A., Finci-Yeheskel, Z., et al.1996). Human follicular nitric oxide pathway: relationship to follicular size, oestradiol concentrations and ovarian blood flow. Human reproduction (Oxford, England), 11, 1947-1951.
5. Balasch, J., Fabregues, F., Penarrubia, J., Carmona, F., Casamitjana, R., Creus, M., et al.2006). Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH. Human reproduction (Oxford, England), 21, 1884-1893. (Pubitemid 44028265)
6. Battaglia C., Salvatori M., Maxia N., Petraglia F., Facchinetti F., & Volpe, A.1999). Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Human reproduction (Oxford, England), 14, 1690-1697. (Pubitemid 29358678)
7. Bergh C., Hillensjo T., Wikland M., Nilsson L., Borg G., & Hamberger, L.1994). Adjuvant growth hormone treatment during in vitro fertilization: a randomized, placebo-controlled study. Fertility and sterility, 62, 113-120. (Pubitemid 24198068)
8. Berkkanoglu M., Isikoglu M., Aydin D., & Ozgur, K.2007). Clinical effects of ovulation induction with recombinant follicle-stimulating hormone supplemented with recombinant luteinizing hormone or low-dose recombinant human chorionic gonadotropin in the midfollicular phase in microdose cycles in poor responders. Fertility and sterility, 88, 665-669. (Pubitemid 47368230)
9. Biljan, M. M., Hemmings, R., & Brassard, N.2005). The outcome of 150 babies following the treatment with letrozole and gonadotrophins. Fertility and Sterility, 84, S95.
10. Broekmans F. J., Knauff E. A., te Velde E. R., Macklon N. S., & Fauser, B. C.2007). Female reproductive ageing: current knowledge and future trends. Trends in endocrinology and metabolism: TEM, 18, 58-65. (Pubitemid 46275460)
11. Broekmans F. J., Kwee J., Hendriks D. J., Mol B. W., & Lambalk, C. B.2006). A systematic review of tests predicting ovarian reserve and IVF outcome. Human reproduction update, 12, 685-718. (Pubitemid 44605509)
12. Broekmans F. J., Soules M. R., & Fauser, B. C.2009). Ovarian aging: mechanisms and clinical consequences. Endocrine reviews, 30, 465-493.
13. Broer S. L., Mol B. W., Hendriks D., & Broekmans, F. J.2009). The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertility and sterility, 91, 705-714.
14. Brzyski R. G., Muasher S. J., Droesch K., Simonetti S., Jones G. S., & Rosenwaks, Z.1988). Follicular atresia associated with concurrent initiation of gonadotropin-releasing hormone agonist and follicle-stimulating hormone for oocyte recruitment. Fertility and sterility, 50, 917-921. (Pubitemid 19017963)
15. Cai, J., Lou, H. Y., Dong, M. Y., Lu, X. E., Zhu, Y. M., Gao, H. J., et al.2007). Poor ovarian response to gonadotropin stimulation is associated with low expression of folliclestimulating hormone receptor in granulosa cells. Fertility and sterility, 87, 1350-1356. (Pubitemid 46829135)
16. Centre for Clinical Effectiveness.2000). In womenlabelled as poor responders to ovulation stimulation in an assisted reproduction program, is there evidence for the effectiveness of increasing the total dose of FSH above 3000 IU? Clayton, Victoria: Centre for Clinical Effectiveness (CCE) 2000:25, Cochrane Database, (2000). HTA-320030660.
17. Cheung, L. P., Lam, P. M., Lok, I. H., Chiu, T. T., Yeung, S. Y., Tjer, C. C., et al.2005). GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial. Human reproduction (Oxford, England), 20, 616-621. (Pubitemid 40425485)
18. Chong A. P., Rafael R. W., & Forte, C. C.1986). Influence of weight in the induction of ovulation with human menopausal gonadotropin and human chorionic gonadotropin. Fertility and sterility, 46, 599-603. (Pubitemid 17179952)
19. D'Amato G., Caroppo E., Pasquadibisceglie A., Carone D., Vitti A., & Vizziello, G. M.2004). A novel protocol of ovulation induction with delayed gonadotropin-releasing hormone antagonist administration combined with high-dose recombinant folliclestimulating hormone and clomiphene citrate for poor responders and women over 35 years. Fertility and sterility, 81, 1572-1577. (Pubitemid 38749001)
20. De Placido, G., Alviggi, C., Mollo, A., Strina, I., Varricchio, M. T., & Molis, M.2000). Recombinant follicle stimulating hormone is effective in poor responders to highly purified follicle stimulating hormone. Human reproduction (Oxford, England), 15, 17-20. (Pubitemid 30035092)
21. Delitala G., Tomasi P., & Virdis, R.1988). Neuroendocrine regulation of human growth hormone secretion. Diagnostic and clinical applications. Journal of endocrinological investigation, 11, 441-462.
22. Detti L., Williams D. B., Robins J. C., Maxwell R. A., & Thomas, M. A.2005). A comparison of three downregulation approaches for poor responders undergoing in vitro fertilization. Fertility and sterility, 84, 1401-1405. (Pubitemid 41571887)
23. Dirnfeld, M., Fruchter, O., Yshai, D., Lissak, A., Ahdut, A., & Abramovici, H.1999). Cessation of gonadotropin-releasing hormone analogue (GnRH-a) upon down-regulation versus conventional long GnRH-a protocol in poor responders undergoing in vitro fertilization. Fertility and sterility, 72, 406-411. (Pubitemid 29414877)
24. Doldi N., Bassan M., Bonzi V., & Ferrari, A.1996). Effects of growth hormone and growth hormone-releasing hormone on steroid synthesis in cultured human luteinizing granulosa cells. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology, 10, 101-108.
25. Domingues T. S., Rocha A. M., & Serafini, P. C.2010). Tests for ovarian reserve: reliability and utility. Current opinion in obstetrics & gynecology, 22, 271-276.
26. Droesch, K., Muasher, S. J., Brzyski, R. G., Jones, G. S., Simonetti, S., Liu, H. C., et al.1989). Value of suppression with a gonadotropin-releasing hormone agonist prior to gonadotropin stimulation for in vitro fertilization. Fertility and sterility, 51, 292-297. (Pubitemid 19050530)
27. Eskandar M., Jaroudi K., Jambi A., Archibong E. I., Coskun S., & Sobande, A. A.2004). Is recombinant follicle-stimulating hormone more effective in IVF poor responders than human menopausal gonadotrophins? Medical science monitor: international medical journal of experimental and clinical research, 10, PI6-PI9. (Pubitemid 38176006)
28. Faber, B. M., Mayer, J., Cox, B., Jones, D., Toner, J. P., Oehninger, S., et al.1998). Cessation of gonadotropin-releasing hormone agonist therapy combined with high-dose gonadotropin stimulation yields favorable pregnancy results in low responders. Fertility and sterility, 69, 826-830. (Pubitemid 28193914)
29. Fabregues, F., Penarrubia, J., Creus, M., Manau, D., Casals, G., Carmona, F., et al.2009). Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial. Human reproduction (Oxford, England), 24, 349-359.
30. Faddy, M. J.2000). Follicle dynamics during ovarian ageing. Molecular and cellular endocrinology, 163, 43-48. (Pubitemid 30645583)
31. Faddy M. J., & Gosden, R. G.1996). A model conforming the decline in follicle numbers to the age of menopause in women. Human reproduction (Oxford, England), 11, 1484-1486. (Pubitemid 26335098)
32. Feldberg D., Farhi J., Ashkenazi J., Dicker D., Shalev J., & Ben-Rafael, Z.1994). Minidose gonadotropin-releasing hormone agonist is the treatment of choice in poor responders with high follicle-stimulating hormone levels. Fertility and sterility, 62, 343-346. (Pubitemid 24233286)
33. Frattarelli, J. L., McWilliams, G. D., Hill, M. J., Miller, K. A., & Scott, R. T., Jr.2008). Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders. Fertility and sterility, 89, 1113-1117. (Pubitemid 351671723)
34. Friden B. E., & Nilsson, L.2005). Gonadotrophin-releasing hormone-antagonist luteolysis during the preceding mid-luteal phase is a feasible protocol in ovarian hyperstimulation before in vitro fertilization. Acta obstetricia et gynecologica Scandinavica, 84, 812-816. (Pubitemid 41039908)
35. Fridstrom M., Akerlof E., Sjoblom P., & Hillensjo T.1997). Serum levels of luteinizing and follicle-stimulating hormones in normal and poor-responding patients undergoing ovarian stimulation with urofollitropin after pituitary downregulation. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology, 11, 25-28. (Pubitemid 27117007)
36. Garcia, J. E., Jones, G. S., Acosta, A. A., & Wright, G., Jr.1983). Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: phase II, 1981. Fertility and sterility, 39, 174-179. (Pubitemid 13195405)
37. Garcia J. E., Padilla S. L., Bayati J., & Baramki, T. A.1990). Follicular phase gonadotropin-releasing hormone agonist and human gonadotropins: a better alternative for ovulation induction in in vitro fertilization. Fertility and sterility, 53, 302-305. (Pubitemid 20076360)
38. Garcia-Velasco, J. A., Isaza, V., Requena, A., Martinez-Salazar, F. J., Landazabal, A., Remohi, J., et al.2000). High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low responder IVF patients: a prospective, randomized, controlled trial. Human reproduction (Oxford, England), 15, 2292-2296.
39. Garcia-Velasco, J. A., Moreno, L., Pacheco, A., Guillen, A., Duque, L., Requena, A., et al.2005). The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study. Fertility and sterility, 84, 82-87. (Pubitemid 40991464)
40. Gibreel A., Maheshwari A., Bhattacharya S., & Johnson, N. P.2009). Ultrasound tests of ovarian reserve; a systematic review of accuracy in predicting fertility outcomes. Human fertility (Cambridge, England), 12, 95-106.
41. Gindoff P. R., Hall J. L., & Stillman, R. J.1990). Ovarian suppression with leuprolide acetate: comparison of luteal, follicular, and flare-up administration in controlled ovarian hyperstimulation for oocyte retrieval. Journal of in vitro fertilization and embryo transfer: IVF, 7, 94-97. (Pubitemid 20212974)
42. Giudice, L. C.1992). Insulin-like growth factors and ovarian follicular development. Endocrine reviews, 13, 641-669. (Pubitemid 23037209)
43. Gleicher, N.& Barad, D.2006). The effect of dehydroepiandrosterone on diminished ovarian reserve. Human reproduction, 21 (Suppl 1), i69.
44. Gordon U. D., Harrison R. F., Fawzy M., Hennelly B., & Gordon, A. C.2001). A randomized prospective assessor-blind evaluation of luteinizing hormone dosage and in vitro fertilization outcome. Fertility and sterility, 75, 324-331. (Pubitemid 32112109)
45. Goswami, S. K., Das, T., Chattopadhyay, R., Sawhney, V., Kumar, J., Chaudhury, K., et al.2004). A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report. Human reproduction (Oxford, England), 19, 2031-2035. (Pubitemid 39236469)
46. Haller K., Salumets A., & Uibo, R.2008). Anti-FSH antibodies associate with poor outcome of ovarian stimulation in IVF. Reproductive biomedicine online, 16, 350-355. (Pubitemid 351419453)
47. Hellberg D., Waldenstrom U., & Nilsson, S.2004). Defining a poor responder in in vitro fertilization. Fertility and sterility, 82, 488-490. (Pubitemid 39092062)
48. Hendriks D. J., Mol B. W., Bancsi L. F., Te Velde E. R., & Broekmans, F. J.2005). Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertility and sterility, 83, 291-301. (Pubitemid 40221779)
49. Hendriks D. J., Mol B. W., Bancsi L. F., te Velde E. R., & Broekmans, F. J.2006). The clomiphene citrate challenge test for the prediction of poor ovarian response and nonpregnancy in patients undergoing in vitro fertilization: a systematic review. Fertility and sterility, 86, 807-818. (Pubitemid 44485046)
50. Hendriks D. J., Kwee J., Mol B. W., te Velde E. R., & Broekmans, F. J.2007). Ultrasonography as a tool for the prediction of outcome in IVF patients: a comparative meta-analysis of ovarian volume and antral follicle count. Fertility and sterility, 87, 764-775. (Pubitemid 46550395)
51. Hernandez, E. R., Hurwitz, A., Vera, A., Pellicer, A., Adashi, E.Y., LeRoith, D., et al.1992). Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary. The Journal of clinical endocrinology and metabolism, 74, 419-425.
52. Homburg R., & Farhi, J.1995). Growth hormone and reproduction. Current opinion in obstetrics & gynecology, 7, 220-223.
53. Homburg R., Eshel A., Abdalla H. I., & Jacobs, H. S.1988). Growth hormone facilitates ovulation induction by gonadotrophins. Clinical endocrinology, 29, 113-117.
54. Horie K., Takakura K., Fujiwara H., Suginami H., Liao S., & Mori, T.1992). Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to oestrogen and progesterone receptor expression. Human reproduction (Oxford, England), 7, 184-190.
55. Horvath P. M., Styler M., Hammond J. M., Shelden R. M., & Kemmann, E.1988). Exogenous gonadotropin requirements are increased in leuprolide suppressed women undergoing ovarian stimulation. Fertility and sterility, 49, 159-162. (Pubitemid 18033911)
56. Howles, C. M., Loumaye, E., Germond, M., Yates, R., Brinsden, P., Healy, D., et al.1999). Does growth hormone-releasing factor assist follicular development in poor responder patients undergoing ovarian stimulation for in-vitro fertilization? Human reproduction (Oxford, England), 14, 1939-1943. (Pubitemid 29381222)
57. Hughes S. M., Huang Z. H., Morris I. D., Matson P. L., Buck P., & Lieberman, B. A.1994). A double-blind cross-over controlled study to evaluate the effect of human biosynthetic growth hormone on ovarian stimulation in previous poor responders to in-vitro fertilization. Human reproduction (Oxford, England), 9, 13-18. (Pubitemid 24043776)
58. Jia X. C., Kalmijn J., & Hsueh, A. J.1986). Growth hormone enhances follicle-stimulating hormone-induced differentiation of cultured rat granulosa cells. Endocrinology, 118, 1401-1409 (Pubitemid 16078513)
59. Kailasam C., Keay S. D., Wilson P., Ford W. C., & Jenkins, J. M.2004). Defining poor ovarian response during IVF cycles, in women aged <40 years and its relationship with treatment outcome Human reproduction Oxford England 19 1544-1547 (Pubitemid 38997178)
60. Jayaprakasan K., Campbell B., Hopkisson J., Johnson I., & Raine- Fenning, N.2010). A prospective, comparative analysis of anti-Mullerian hormone, inhibin-B, and three-dimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation. Fertility and sterility, 93, 855-864.
61. Jayaprakasan, K., Al-Hasie, H., Jayaprakasan, R., Campbell, B., Hopkisson, J., Johnson, I., et al.2009). The three-dimensional ultrasonographic ovarian vascularity of women developing poor ovarian response during assisted reproduction treatment and its predictive value. Fertility and sterility, 92, 1862-1869.
62. Kansal Kalra S., Ratcliffe S., Gracia C. R., Martino L., Coutifaris C., & Barnhart, K. T.2008). Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reproductive biomedicine online, 17, 745-750.
63. Karande V. C., Jones G. S., Veeck L. L., & Muasher, S. J.1990). High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients. Fertility and sterility, 53, 486-489. (Pubitemid 20093612)
64. Karande V., Morris R., Rinehart J., Miller C., Rao R., & Gleicher, N.1997). Limited success using the "flare" protocol in poor responders in cycles with low basal follicle-stimulating hormone levels during in vitro fertilization. Fertility and sterility, 67, 900-903. (Pubitemid 27195031)
65. Katayama K. P., Roesler M., Gunnarson C., Stehlik E., & Jagusch, S.1988). Short-term use of gonadotropin-releasing hormone agonist (leuprolide) for in vitro fertilization. Journal of in vitro fertilization and embryo transfer: IVF, 5, 332-334. (Pubitemid 19026471)
66. Keay S. D., Liversedge N. H., & Jenkins, J. M.1998). Could ovarian infection impair ovarian response to gonadotrophin stimulation? British journal of obstetrics and gynaecology, 105, 252-253.
67. Keay S. D., Liversedge N. H., Mathur R. S., & Jenkins, J. M.1997). Assisted conception following poor ovarian responseto gonadotrophin stimulation. British journal of obstetrics and gynaecology, 104, 521-527. (Pubitemid 27240414)
68. Kim C. H., Chae H. D., & Chang, Y. S.1999). Pyridostigmine cotreatment for controlled ovarian hyperstimulation in low responders undergoing in vitro fertilization-embryo transfer. Fertility and sterility, 71, 652-657.
69. Kim C. H., Howles C. M., & Lee, H. A.2011). The effect of transdermal testosterone gel pretreatment on controlled ovarian stimulation and IVF outcome in low responders. Fertility and sterility, 95, 679-683.
70. Klinkert E. R., Broekmans F. J., Looman C. W., Habbema J. D., & te Velde, E. R.2005). Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial. Human reproduction (Oxford, England), 20, 611-615. (Pubitemid 40425484)
71. Kolibianakis E. M., Venetis C. A., Diedrich K., Tarlatzis B. C., & Griesinger, G.2009). Addition of growth hormone to gonadotrophins in ovarian stimulation of poor responders treated by in-vitro fertilization: a systematic review and metaanalysis. Human reproduction update, 15, 613-622.
72. Kucuk T., & Sozen, E.2007). Luteal start of exogenous FSH in poor responder women. Journal of assisted reproduction and genetics, 24, 635-638.
73. Kupesic S., Kurjak A., Bjelos D., & Vujisic, S.2003). Three-dimensional ultrasonographic ovarian measurements and in vitro fertilization outcome are related to age. Fertility and sterility, 79, 190-197. (Pubitemid 36071261)
74. Kyrou D., Kolibianakis E. M., Venetis C. A., Papanikolaou E. G., Bontis J., & Tarlatzis, B. C.2009). How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertility and sterility, 91, 749-766.
75. La Marca, A., Sighinolfi, G., Radi, D., Argento, C., Baraldi, E., Artenisio, A. C., et al.2010). Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART). Human reproduction update, 16, 113-130.
76. Land J. A., Yarmolinskaya M. I., Dumoulin J. C., & Evers, J. L.1996). High-dose human menopausal gonadotropin stimulation in poor responders does not improve in vitro fertilization outcome. Fertility and sterility, 65, 961-965. (Pubitemid 26126828)
77. Lanzone A., Di Simone N., Castellani R., Fulghesu A. M., Caruso A., & Mancuso, S.1992). Human growth hormone enhances progesterone production by human luteal cells in vitro: evidence of a synergistic effect with human chorionic gonadotropin. Fertility and sterility, 57, 92-96.
78. Lee, D. W., Grasso, P., Dattatreyamurty, B., Deziel, M. R., & Reichert, L. E., Jr.1993). Purification of a high molecular weight follicle-stimulating hormone receptor-binding inhibitor from human follicular fluid. The Journal of clinical endocrinology and metabolism, 77, 163-168. (Pubitemid 23206796)
79. Lekamge D. N., Lane M., Gilchrist R. B., & Tremellen, K. P.2008). Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve. Journal of assisted reproduction and genetics, 25, 515-521.
80. Loh S., Wang J. X., & Matthews, C. D.2002). The influence of body mass index, basal FSH and age on the response to gonadotrophin stimulation in non-polycystic ovarian syndrome patients. Human reproduction (Oxford, England), 17, 1207-1211. (Pubitemid 34537350)
81. Lok I. H., Yip S. K., Cheung L. P., Yin Leung P. H., & Haines, C. J.2004). Adjuvant low-dose aspirin therapy in poor responders undergoing in vitro fertilization: a prospective, randomized, double-blind, placebo-controlled trial. Fertility and sterility, 81, 556-561. (Pubitemid 38376110)
82. Loutradis, D., Patsoula, E., Minas, V., Koussidis, G. A., Antsaklis, A., Michalas, S., et al.2006). FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs. Journal of assisted reproduction and genetics, 23, 177-184. (Pubitemid 43873809)
83. Loutradis D., Vomvolaki E., & Drakakis, P.2008). Poor responder protocols for in-vitro fertilization: options and results. Current opinion in obstetrics & gynecology, 20, 374-378.
84. Maheshwari A., Gibreel A., Bhattacharya S., & Johnson, N. P.2009). Dynamic tests of ovarian reserve: a systematic review of diagnostic accuracy. Reproductive biomedicine online, 18, 717-734.
85. Malmusi, S., La Marca, A., Giulini, S., Xella, S., Tagliasacchi, D., Marsella, T., et al.2005). Comparison of a gonadotropinreleasing hormone (GnRH) antagonist and GnRH agonist flareupregimen in poor responders undergoing ovarian stimulation. Fertility and sterility, 84, 402-406. (Pubitemid 41125261)
86. Marci R., Caserta D., Dolo V., Tatone C., Pavan A., & Moscarini, M.2005). GnRH antagonist in IVF poor-responder patients: results of a randomized trial. Reproductive biomedicine online, 11, 189-193. (Pubitemid 41086943)
87. Martinez, F., Barri, P. N., Coroleu, B., Tur, R., Sorsa-Leslie, T., Harris, W. J., et al.2002). Women with poor response to IVF have lowered circulating gonadotrophin surge-attenuating factor (GnSAF) bioactivity during spontaneous and stimulated cycles. Human reproduction (Oxford, England), 17, 634-640. (Pubitemid 34232432)
88. Massin N., Cedrin-Durnerin I., Coussieu C., Galey-Fontaine J., Wolf J. P., & Hugues, J. N.2006). Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction technique-a prospective, randomized, double-blind study. Human reproduction (Oxford, England), 21, 1204-1211.
89. Mochtar M. H., Van der Veen Ziech, M. & van Wely M.2007). Recombinant Luteinizing Hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane database of systematic reviews (Online), 18;(2): CD005070.
90. Mohiyiddeen L., & Nardo, L. G.2010). Single-nucleotide polymorphisms in the FSH receptor gene and ovarian performance: future role in IVF. Human fertility (Cambridge, England), 13, 72-78.
91. Moncada S., Palmer R. M., & Higgs, E. A.1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological reviews, 43, 109-142.
92. Moreno C., Ruiz A., Simon C., Pellicer A., & Remohi J.1998). Intracytoplasmic sperm injection as a routine indication in low responder patients. Human reproduction (Oxford, England), 13, 2126-2129. (Pubitemid 28425100)
93. Morgia, F., Sbracia, M., Schimberni, M., Giallonardo, A., Piscitelli, C., Giannini, P., et al.2004). A controlled trial of natural cycle versus microdose gonadotropin-releasing hormone analog flare cycles in poor responders undergoing in vitro fertilization. Fertility and sterility, 81, 1542-1547. (Pubitemid 38748996)
94. Muttukrishna S., McGarrigle H., Wakim R., Khadum I., Ranieri D. M., & Serhal, P.2005). Antral follicle count, anti-mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology? BJOG: an international journal of obstetrics and gynaecology, 112, 1384-1390. (Pubitemid 43961267)
95. Nargund G., & Bromhan, D.1995). Comparison of endocrinological and clinical profiles and outcome of IVF cycles in patients with one ovary and two ovaries. Journal of assisted reproduction and genetics, 12, 458-460.
96. Nelson S. M., Yates R. W., & Fleming, R.2007). Serum anti- Mullerian hormone and FSH: prediction of live birth and extremes of response in stimulated cycles-implications for individualization of therapy. Human reproduction (Oxford, England), 22, 2414-2421. (Pubitemid 47289055)
97. Nelson, S. M., Yates, R. W., Lyall, H., Jamieson, M., Traynor, I., Gaudoin, M., et al.2009). Anti-Mullerian hormone-based approach to controlled ovarian stimulation for assisted conception. Human reproduction (Oxford, England), 24, 867-875.
98. Nilsson L., Andersen A. N., Lindenberg S., Hausken J., Andersen C. Y., & Kahn, J. A.2010). Ganirelix for luteolysis in poor responder patients undergoing IVF treatment: a Scandinavian multicenter 'extended pilot study'. Acta obstetricia et gynecologica Scandinavica, 89, 828-831.
99. Olivennes, F., Righini, C., Fanchin, R., Torrisi, C., Hazout, A., Glissant, M., et al.1996). A protocol using a low dose of gonadotrophin- releasing hormone agonist might be the best protocol for patients with high follicle-stimulating hormone concentrations on day 3. Human reproduction (Oxford, England), 11, 1169-1172. (Pubitemid 26245307)
100. Padilla S. L., Dugan K., Maruschak V., Shalika S., & Smith, R. D.1996). Use of the flare-up protocol with high dose human follicle stimulating hormone and human menopausal gonadotropins for in vitro fertilization in poor responders. Fertility and sterility, 65, 796-799. (Pubitemid 26096921)
101. Palter S. F., Tavares A. B., Hourvitz A., Veldhuis J. D., & Adashi, E. Y.2001). Are estrogens of import to primate/human ovarian folliculogenesis? Endocrine reviews, 22, 389-424 (Pubitemid 32554364)
102. Pan H. A., Cheng Y. C., Li C. H., Wu M. H., & Chang, F. M.2002). Ovarian stroma flow intensity decreases by age: a threedimensional power doppler ultrasonographic study. Ultrasound in medicine & biology, 28, 425-430.
103. Pandey S., Pandey S., Maheshwari A., & Bhattacharya, S.2010). The impact of female obesity on the outcome of fertility treatment. Journal of human reproductive sciences, 3, 62-67.
104. Pandian, Z., McTavish, A. R., Aucott, L., Hamilton, M. P., &Bhattacharya, S.2010). Interventions for 'poor responders' to controlled ovarian hyper stimulation (COH) in in-vitro fertilisation (IVF). Cochrane Database of Systematic Reviews, 20, CD004379.
105. Pellicer A., Ardiles G., Neuspiller F., Remohi J., Simon C., & Bonilla-Musoles, F.1998). Evaluation of the ovarian reserve in young low responders with normal basal levels of folliclestimulating hormone using three-dimensional ultrasonography. Fertility and sterility, 70, 671-675. (Pubitemid 28478183)
106. Pellicer, A., Ballester, M. J., Serrano, M. D., Mir, A., Serra-Serra, V., Remohi, J., et al.1994). Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels. Human reproduction (Oxford, England), 9, 806-811. (Pubitemid 24168062)
107. Perez Mayorga M., Gromoll J., Behre H. M., Gassner C., Nieschlag E., & Simoni, M.2000). Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. The Journal of clinical endocrinology and metabolism, 85, 3365-3369.
108. Pru J. K., & Tilly, J. L.2001). Programmed cell death in the ovary: insights and future prospects using genetic technologies. Molecular endocrinology (Baltimore, Md.), 15, 845-853. (Pubitemid 32510634)
109. Raga F., Bonilla-Musoles F., Casan E. M., & Bonilla, F.1999). Recombinant follicle stimulating hormone stimulation in poor responders with normal basal concentrations of follicle stimulating hormone and oestradiol: improved reproductive outcome. Human reproduction (Oxford, England), 14, 1431-1434. (Pubitemid 29265428)
110. Rombauts L., Suikkari A. M., MacLachlan V., Trounson A. O., & Healy, D. L.1998). Recruitment of follicles by recombinant human follicle-stimulating hormone commencing in the luteal phase of the ovarian cycle. Fertility and sterility, 69, 665-669. (Pubitemid 28188461)
111. Rosencrantz M. A., Wachs D. S., Coffler M. S., Malcom P. J., Donohue M., & Chang, R. J.2010). Comparison of inhibin B and estradiol responses to intravenous FSH in women with polycystic ovary syndrome and normal women. Human reproduction (Oxford, England), 25, 198-203.
112. Schmidt D. W., Bremner T., Orris J. J., Maier D. B., Benadiva C. A., & Nulsen, J. C.2005). A randomized prospective study of microdose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders. Fertility and sterility, 83, 1568-1571. (Pubitemid 40615845)
113. Schoolcraft W., Schlenker T., Gee M., Stevens J., & Wagley, L.1997). Improved controlled ovarian hyperstimulation in poor responder in vitro fertilization patients with a microdose folliclestimulating hormone flare, growth hormone protocol. Fertility and sterility, 67, 93-97. (Pubitemid 26428419)
114. Schoolcraft, W. B., Surrey, E. S., Minjarez, D. A., Stevens, J. M., & Gardner, D. K.2008). Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol? Fertility and sterility, 89, 151-156.
115. Scott R. T., & Navot, D.1994). Enhancement of ovarian responsiveness with microdoses of gonadotropin-releasing hormone agonist during ovulation induction for in vitro fertilization. Fertility and sterility, 61, 880-885. (Pubitemid 24136854)
116. Seifer D. B., Lambert-Messerlian G., Hogan J. W., Gardiner A. C., Blazar A. S., & Berk, C. A.1997). Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertility and sterility, 67, 110-114. (Pubitemid 26428422)
117. Sills E. S., Alper M. M., & Walsh, A. P.2009). Ovarian reserve screening in infertility: practical applications and theoretical directions for research. European journal of obstetrics, gynecology, and reproductive biology, 146, 30-36.
118. Simon Brown. May 2010; Poor ovarian response: from the 'unknown' to consensus in definition and prognostic tests. Focus on Reproduction 24-25; ESHRE Special Interest Group- Multidisciplinary Consensus Meeting.
119. Simoni M., Gromoll J., & Nieschlag, E.1997). The folliclestimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocrine reviews, 18, 739-773.
120. Simoni M., Nieschlag E., & Gromoll, J.2002). Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Human reproduction update, 8, 413-421. (Pubitemid 35175203)
121. Sladkevicius P., Valentin L., & Marsa, l K.1993). Blood flow velocity in the uterine and ovarian arteries during the normal menstrual cycle. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 3, 199-208.
122. Smulders, B., van Oirschot, S. M., Farquhar, C., Rombauts, L., &Kremer, J. A.2010). Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques. Cochrane Database of Systematic Reviews, 20, CD006109.
123. Spandorfer S., Navarro J., Kump L. M., Liu H. C., Davis O. K., & Rosenwaks, Z.2001). "Co-Flare" stimulation in the poor responder patient: predictive value of the flare response. Journal of assisted reproduction and genetics, 18, 629-633. (Pubitemid 34059806)
124. Surrey E. S., Bower J., Hill D. M., Ramsey J., & Surrey, M. W.1998). Clinical and endocrine effects of a microdose GnRH agonist flare regimen administered to poor responders who are undergoing in vitro fertilization. Fertility and sterility, 69, 419-424
125. Surrey, E. S.2007). Management of the poor responder: the role of GnRH agonists and antagonists. Journal of assisted reproduction and genetics, 24, 613-619.
126. Suzuki, T., Sasano, H., Kimura, N., Tamura, M., Fukaya, T., Yajima, A., et al.1994). Immunohistochemical distribution of progesterone, androgen and oestrogen receptors in the human ovary during the menstrual cycle: relationship to expression of steroidogenic enzymes. Human reproduction (Oxford, England), 9, 1589-1595. (Pubitemid 24291067)
127. Tarlatzis B. C., Zepiridis L., Grimbizis G., & Bontis, J.2003). Clinical management of low ovarian response to stimulation for IVF: a systematic review. Human reproduction update, 9, 61-76. (Pubitemid 36305584)
128. Templeton A., Morris J. K., & Parslow, W.1996). Factors that affect outcome of in-vitro fertilisation treatment. Lancet, 348, 1402-1406. (Pubitemid 26395234)
129. Tesarik, J., Hazout, A., & Mendoza, C.2005). Improvement of delivery and live birth rates after ICSI in women aged >40 years by ovarian co-stimulation with growth hormone. Human reproduction (Oxford, England), 20, 2536-2541. (Pubitemid 41222503)
130. Toth T. L., Awwad J. T., Veeck L. L., Jones H. W., Jr & Muasher S. J.1996). Suppression and flare regimens of gonadotropinreleasing hormone agonist. Use in women with different basal gonadotropin values in an in vitro fertilization program. The Journal of reproductive medicine, 41, 321-326. (Pubitemid 26172565)
131. Tulandi, T., Martin, J., Al-Fadhli, R., Kabli, N., Forman, R., Hitkari, J., et al.2006). Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertility and sterility, 85, 1761-1765. (Pubitemid 43816444)
132. Ubaldi, F.2010). Poor ovarian response: from the 'unknown' to consensus in definition and prognostic tests. Focus on Reproduction 24-25; ESHRE Special Interest Group- Multidisciplinary Consensus Meeting.
133. Van Rooij, I. A., Broekmans, F. J., te Velde, E. R., Fauser, B. C., Bancsi, L. F., de Jong, F. H., et al.2002). Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve. Human reproduction (Oxford, England), 17, 3065-3071. (Pubitemid 35469254)
134. Weenen, C., Laven, J. S., Von Bergh, A. R., Cranfield, M., Groome, N. P., Visser, J. A., et al.2004). Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Molecular human reproduction, 10, 77-83. (Pubitemid 38196508)
135. Weissman A., Farhi J., Royburt M., Nahum H., Glezerman M., & Levran, D.2003). Prospective evaluation of two stimulation protocols for low responders who were undergoing in vitro fertilization-embryo transfer. Fertility and sterility, 79, 886-892. (Pubitemid 36385008)
136. Yarali H., Esinler I., Polat M., Bozdag G., & Tiras, B.2009). Antagonist/letrozole protocol in poor ovarian responders for intracytoplasmic sperm injection: a comparative study with the microdose flare-up protocol. Fertility and sterility, 92, 231-235.
137. Younis, J. S., Jadaon, J., Izhaki, I., Haddad, S., Radin, O., Bar-Ami, S., et al.2010). A simple multivariate score could predict ovarian reserve, as well as pregnancy rate, in infertile women. Fertility and sterility, 94, 655-661.
138. Zaidi J., Barber J., Kyei-Mensah A., Bekir J., Campbell S., & Tan, S. L.1996). Relationship of ovarian stromal blood flow at the baseline ultrasound scan to subsequent follicular response in an in vitro fertilization program. Obstetrics and gynecology, 88, 779-784. (Pubitemid 26360818)
139. Zeleznik, A. J., Schuler, H. M., & Reichert, L. E., Jr.1981). Gonadotropin-binding sites in the rhesus monkey ovary: role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle. Endocrinology, 109, 356-362. (Pubitemid 11040185)