AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr+/- mice

Journal of Cardiovascular Translational Research

Volumn 4, Issue 6, 2011, Pages 801-810

  Chen, Zhu ^a   Chu, Donald ^a   Castro Perez, Jose M ^a   Ni, Weihua ^a   Zhang, Aiwu ^a   Krsmanovic, Mihajlo L ^a   Xie, Dan ^a   Shah, Vinit ^a   Stout, Steven J ^a   McLaren, David G ^a   Stefanni, Alice C ^a   Lee, Sang Ho ^a   Roddy, Thomas P ^a   Plump, Andrew S ^a   Hubbard, Brian K ^a   Vogt, Thomas F ^a   Zhou, Heather H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

AAV8; HDL; LCAT; LDL; Triglycerides

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYSOPHOSPHATIDYLCHOLINE; PARVOVIRUS VECTOR; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DYSLIPIDEMIA; ENZYME ACTIVITY; ENZYME SPECIFICITY; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTYPE; SINGLE DRUG DOSE; TRIACYLGLYCEROL BLOOD LEVEL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; CHOLESTEROL ESTER TRANSFER PROTEINS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DYSLIPIDEMIAS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; HUMANS; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PARTICLE SIZE; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; RECEPTORS, LDL; TIME FACTORS;

MUS;

EID: 81855221703     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-011-9309-8     Document Type: Article

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