The effect of pregnancy on seizure control and antiepileptic drugs in women with epilepsy

Reviews in Neurological Diseases

Volumn 8, Issue 1-2, 2011, Pages 16-22

  Burakgazi, Evren ^a   Pollard, John ^b   Harden, Cynthia ^c  

^a Department of Anesthesiology   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

Author keywords

Antiepileptic drugs; Breastfeeding; Epilepsy; Pharmacokinetics; Pregnancy; Seizure control

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; FOLIC ACID; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PREGABALIN; RUFINAMIDE; SERUM ALBUMIN; TOPIRAMATE; VALPROIC ACID; VITAMIN K GROUP; ZONISAMIDE;

AWARENESS; BREAST FEEDING; CONCEPTION; COUNSELING; DELIVERY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; EPILEPSY; FETUS; GASTROINTESTINAL MOTILITY; HUMAN; KIDNEY CLEARANCE; MOTHER; NEWBORN MONITORING; PHYSICIAN; PLASMA VOLUME; PRACTICE GUIDELINE; PREGNANCY; PUERPERIUM; RECURRENT ABORTION; REVIEW; RISK; SEIZURE; TOTAL BODY WATER;

ANTICONVULSANTS; BREAST FEEDING; DRUG MONITORING; FEMALE; FETUS; HUMANS; POSTPARTUM PERIOD; PRECONCEPTION CARE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL CARE; SEIZURES;

EID: 81855218793     PISSN: 15452913     EISSN: None     Source Type: Journal    
DOI: 10.3909/rind0270     Document Type: Review

References (48)

1. Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc. 1996;71:576-586.
2. Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry. 2006;77:193-198. (Pubitemid 43220841)
3. Meador K, Reynolds MV, Crean S, et al. Pregnancy outcomes in women with epilepsy: a systematic review and metaanalysis of published pregnancy registries and cohorts. Epilepsy Res. 2008;81:1-13.
4. Kaplan PW, Norwitz ER, Ben-Menachem E, et al. Obstetric risks for women with epilepsy during pregnancy. Epilepsy Behav. 2007;11: 283-291. (Pubitemid 350048498)
5. Fried S, Kozer E, Nulman I, et al. Malformation rates in children of women with untreated epilepsy. Drug Saf. 2004;27:197-202. (Pubitemid 38315328)
6. Gaily E, Kantola-Sorsa E, Hiilesmaa V, et al. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology. 2004;62:28-32. (Pubitemid 38082865)
7. Tomson T, Hiilesmaa V. Epilepsy in pregnancy. BMJ. 2007;335:769-773. (Pubitemid 47612634)
8. Meador KJ, Pennell PB, Harden CL, et al. Pregnancy registries in epilepsy: a consensus statement on health outcomes. Neurology. 2008;71:1109-1117.
9. Tomson T, Battino D. Pharmacokinetics and therapeutic drug monitoring of newer antiepileptic drugs during pregnancy and the puerperium. Clin Pharmacokinet. 2007;46:209-219. (Pubitemid 46425647)
10. Sabers A, Petrenaite V. Pharmacokinetics of antiepileptic drugs in pregnancy. Expert Rev Clin Pharmacol. 2008;1:129-136.
11. Lipka K, Bülow HH. Lactic acidosis following convulsions. Acta Anaesthesiol Scand. 2003;47:616-618. (Pubitemid 36539509)
12. Hiilesmaa VK, Bardy A, Teramo K. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol. 1985;152:499-504. (Pubitemid 15039823)
13. Teramo K, Hiilesmaa V, Bardy A, Saarikoski S. Fetal heart rate during a maternal grand mal epileptic seizure. J Perinat Med. 1979;7:3-6. (Pubitemid 9100233)
14. Harden CL, Pennell PB, Koppel BS, et al. Management issues for women with epilepsy-focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia. 2009;50:1247-1255.
15. Harden CL, Meador KJ, Pennell PB, et al. Management issues for women with epilepsy-focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia. 2009;50:1237-1246.
16. Harden CL, Hopp J, Ting TY, et al. Management issues for women with epilepsy-focus on pregnancy (an evidence-based review): I. Obstetrical complications and change in seizure frequency: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia. 2009;50:1229-1236.
17. Winterbottom J, Smyth R, Jacoby A, Baker G. The effectiveness of preconception counseling to reduce adverse pregnancy outcome in women with epilepsy: what's the evidence? Epilepsy Behav. 2009;14:273-279.
18. Kampman MT, Johansen S, Stenvold H, Acharya G. Management of women with epilepsy: are guidelines being followed? Results from case-note reviews and a patient questionnaire. Epilepsia. 2005;46:1286-1292. (Pubitemid 41647769)
19. Sabers A. Influences on seizure activity in pregnant women with epilepsy. Epilepsy Behav. 2009;15:230-234.
20. EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP Epilepsy Pregnancy Registry. Neurology. 2006;66:354-360.
21. Gjerde IO, Strandjord RE, Ulstein M. The course of epilepsy during pregnancy: a study of 78 cases. Acta Neurol Scand. 1988;78:198-205.
22. Bardy AH. Incidence of seizures during pregnancy, labor and puerperium in epileptic women: a prospective study. Acta Neurol Scand. 1987;75:356-360. (Pubitemid 17086656)
23. Westin AA, Reimers A, Helde G, et al. Serum concentration/dose ratio of levetiracetam before, during and after pregnancy. Seizure. 2008;17:192-198.
24. Pennell PB, Peng L, Newport DJ, et al. Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology. 2008;70:2130-2136.
25. Petrenaite V, Sabers A, Hansen-Schwartz J. Seizure deterioration in women treated with oxcarbazepine during pregnancy. Epilepsy Res. 2009;84:245-249.
26. Westin AA, Nakken KO, Johannessen SI, et al. Serum concentration/dose ratio of topiramate during pregnancy. Epilepsia. 2009;50:480-485.
27. Ohman I, Sabers A, de Flon P, et al. Pharmacokinetics of topiramate during pregnancy. Epilepsy Res. 2009;87:124-129.
28. Vajda FJ, Hitchcock A, Graham J, et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol. 2006;13:645-654. (Pubitemid 43873638)
29. Ohman I, Luef G, Tomson T. Effects of pregnancy and contraception on lamotrigine disposition: new insight through analysis of lamotrigine metabolites. Seizure. 2008;17:199-202.
30. Mazzucchelli I, Onat FY, Ozkara C, et al. Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium. Epilepsia. 2006;47:504-509. (Pubitemid 43351552)
31. Tomson T, Lindbom U, Ekqvist B, Sundqvist A. Epilepsy and pregnancy: a prospective study of seizures control in relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia. 1994;35:122-130. (Pubitemid 24074475)
32. Philbert A, Petersen B, Dam M. Concentration of valproate during pregnancy, in the newborn and in breast milk. Acta Neurol Scand. 1985;72:460-463. (Pubitemid 16204980)
33. Petrenaite V, Sabers A, Hansen-Schwartz J. Individual changes in lamotrigine plasma concentrations during pregnancy. Epilepsy Res. 2005;65:185-188. (Pubitemid 41187572)
34. Christensen J, Sabers A, Sidenius P. Oxcarbazepine concentrations during pregnancy: a retrospective study in patients with epilepsy. Neurology. 2006;67:1497-1499. (Pubitemid 44632087)
35. Tomson T, Palm R, Källén K, et al. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period and lactation. Epilepsia. 2007;48:1111-1116. (Pubitemid 46854871)
36. López-Fraile IP, Cid AO, Juste AO, Modrego PJ. Levetiracetam plasma level monitoring during pregnancy, delivery, and postpartum: clinical and outcome implications. Epilepsy Behav. 2009;15:372-375.
37. Bardy AH, Teramo K, Hiilesmaa VK. Apparent clearance of phenytoin, phenobarbitone, primidone, and carbamazepine during pregnancy: results of the prospective Helsinki study. In: Janz D, Dam M, Richens A, et al., eds. Epilepsy, Pregnancy, and the Child. New York, NY: Raven Press; 1982:141-145.
38. Lander CM, Eadie MJ. Plasma antiepileptic drug concentration during pregnancy. Epilepsia. 1991;32:257-266.
39. Yerby MS, Friel PN, McCormick K, et al. Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding. Epilepsy Res. 1990;5:223-228. (Pubitemid 20125552)
40. Kuhnz W, Koch S, Helge H, Nau H. Primidone and phenobarbital during lactation period in epileptic women: total and free drug levels in the nursed infants and their effects on neonatal behavior. Dev Pharmacol Ther. 1988;11:147-154.
41. Nau H, Rating D, Häuser I, et al. Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers. Eur J Clin Pharmacol. 1980;18:31-42. (Pubitemid 10090664)
42. Nau H, Rating D, Koch S, et al. Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. J Pharmacol Exp Ther. 1981;219:768-777. (Pubitemid 12248841)
43. Kuhnz W, Jäger-Roman E, Rating D, et al. Carbamazepine and carbamazepine-10, 11-epoxide during pregnancy and postnatal period in epileptic mothers and their nursed infants: clinical and pharmacokinetic effects. Pediatr Pharmacol (New York). 1983;3:199-208. (Pubitemid 14102403)
44. Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia. 2000;41:709-713. (Pubitemid 30390423)
45. Ohman I, Vitols S, Luef G, et al. Topiramate kinetics during delivery, lactation, and in the neonate: preliminary observations. Epilepsia. 2002;43:1157-1160. (Pubitemid 35176121)
46. Ohman I, Vitols S, Tomson T. Pharmacokinetics of gabapentin during delivery, in the neonatal period and lactation: does fetal accumulation occur during pregnancy? Epilepsia. 2005;46:1621-1624. (Pubitemid 44921936)
47. Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum in breast milk at birth and during lactation. Epilepsia. 2005;46:775-777. (Pubitemid 40628677)
48. Meador KJ, Baker GA, Browning N, et al.; the NEAD Study Group. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010;75:1954-1960.