Determination of residual antiplatelet activity of clopidogrel before neuraxial injections

British Journal of Anaesthesia

Volumn 107, Issue 6, 2011, Pages 966-971

  Benzon, H T ^a   McCarthy, R J ^a   Benzon, H A ^b   Kendall, M C ^a   Robak, S ^a   Lindholm, P F ^a   Kallas, P G ^a   Katz, J A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

coagulation; complications; epidural

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ADRENALIN; CLOPIDOGREL; COLLAGEN; STEROID;

ADULT; AGED; ARTICLE; BIOASSAY; CLINICAL ARTICLE; DRUG ACTIVITY; DRUG ADMINISTRATION ROUTE; FEMALE; FOLLOW UP; HUMAN; MALE; NEUROAXIAL INJECTION; PRIORITY JOURNAL; THROMBOCYTE FUNCTION;

EID: 81855217370     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer298     Document Type: Article

References (34)

1. Mohammad RA, Goldberg T, Dorsch MP, Cheng JW. Antiplatelet therapy after placement of a drug-eluting stent: a review of efficacy and safety studies. Clin Ther 2010; 32: 2265-81
2. Field TS, Benavente OR. Current status of antiplatelet agents to prevent stroke. Curr Neurol Neurosci Rep 2011; 11: 6-14
3. Fox KA, Mehta SR, Peters R, et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events (CURE) trial. Circulation 2004; 110: 1202-8
4. Braunwald E, Antman EM, Beasley JW, et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-2002: summary article: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina). Circulation 2002; 106: 1893-900
5. Horlocker TT, Wedel DJ, Rowlingson JC, et al. Regional anesthesia in the patient receiving antithrombotic therapy or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine evidence-based guidelines (third edition). Reg Anesth Pain Med 2010; 35: 64-101
6. Vandermeulen E, Singelyn F, Vercauteren M, Brichant JF, Icks BE, Gautier P. The Belgian Association for Regional Anesthesia Working Party on Anticoagulants and Central Nerve Blocks. Belgian guidelines concerning central neural blockade in patients with drug-induced alteration of coagulation: an update. Acta Anaesth Belg 2005; 56: 139-46
7. Gogarten W, Van Aken H, Buttner J, Reiss H, Wulf H, Burkle H. Regional anesthesia and thromboembolism prophylaxis/anticoagulation- revised recommendations of the German Society of Anaesthesiology and Intensive Care Medicine. Anasth Intensivemed 2007; 48: S109-24
8. Breivik H, Bang U, Jalonen J, Vigfusson G, Alahuhta S, Lagerkranser M. Nordic guidelines for neuraxial blocks in disturbed haemostasis from the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. Acta Anaesthesiol Scand 2010; 54: 16-41
9. Bergman L, Kienbaum P, Gorlinger K, Peters J. Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid. Reg Anesth Pain Med 2007; 32: 354-7
10. Broad L, Lee T, Conroy M, et al. Successful management of patients with a drug-eluting coronary stent presenting or elective, non-cardiac surgery. Br J Anaesth 2007; 98: 19-22
11. Benzon HT, Fragen R, Benzon HA, Savage J, Robinson J, Puri L. Clopidogrel and neuraxial block: the role of the PFA II and P2Y12 assays. Reg Anesth Pain Med 2009; 35: 115
12. Lordkipanidzé M, Pharand C, Nguyen TA, Schampaert E, Palisaitis DA, Diodati JG. Comparison of four tests of platelet function by clopidogrel in stable coronary artery disease patients. Eur Heart J 2008; 29: 2877-85
13. Muller I, Besta F, Schulz C, Massberg S, Schonig A, Gawaz M. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary artery placement. Thromb Haemost 2003; 89: 783-7
14. Price MJ, Coleman JL, Steinhubl SR, Wong GB, Cannon CP, Teirstein PS. Onset and offset of platelet inhibition after high-dose clopidogrel loading and standard daily therapy measured by a point-of-care assay in healthy volunteers. Am J Cardiol 2006; 98: 681-4
15. Rosencher N, Bonnet MP, Sessler DI. Selected new antithrombotic agents and neuraxial anesthesia for major orthopedic surgery: management strategies. Br J Anaesth 2007; 62: 1154-60
16. Haubelt H, Anders C, Vogt A, Hoerdt P, Seyfert UT, Hellstern P. Variables influencing Platelet Function Analyzer-100TM closure times in healthy individuals. Br J Haematol 2005; 130: 759-67
17. Madsen EH, Schmidt EB, Maurer-Spurej E, Kristensen S. Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100. Platelets 2008; 19: 335-41
18. Panicia R, Antonucci E, Gori AM, et al. Different methodologies for evaluating the effect of clopidogrel on platelet function in highrisk coronary artery disease patients. Thromb Haemost 2007; 5: 1839-47
19. Linneman B, Schwonberg J, Rechner AR, Mani H, Lindhoff-Last E. Assessment of clopidogrel non-response by the PFA-100 system using the new test cartridge INNOVANCE PFA P2Y. Ann Hematol 2010; 89: 597-605
20. Payne CD, Li YG, Small DS, et al. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. J Cardiovasc Pharmacol 2007; 50: 555-62
21. Wallentin L. P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. Eur Heart J 2009; 30: 1964-77
22. George JN. Platelets. Lancet 2000; 355: 1531-9
23. Weber AA, Braun M, Hohfeld T, Schwippert B, Tschope D, Schrór K. Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers. Br J Clin Pharmacol 2001; 52: 333-6
24. Benzon HT, Wong HY, Siddiqui T, Ondra S. Caution in performing epidural injections in patients on several antiplatelet drugs. Anesthesiology 1999; 91: 1558-9
25. Osta WA, Akbary H, Fuleihan SF. Epidural analgesia in vascular surgery patients actively taking clopidogrel. Br J Anaesth 2010; 104: 429-32
26. Litz RJ, Gottschlich B, Stehr SN. Spinal epidural hematoma after spinal anesthesia in a patient treated with clopidogrel and enoxaparin. Anesthesiology 2004; 101: 1467-70
27. Tam NLK, Pac-Soo C, Pretorius PM. Epidural haematoma after a combined spinal-epidural anaesthetic in a patient treated with clopidogrel and dalteparin. Br J Anaesth 2006; 96: 262-5
28. Park SH, Kim W, Park CS, Kang WY, Hwang SH, Kim W. A comparison of clopidogrel responsiveness in patients with versus without chronic renal failure. Am J Cardiol 2009; 104: 1292-5
29. Angiolilo DJ, Fernandez-Ortiz A, Bernardo E, et al. Platelet dysfunction profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005; 54: 2430-5
30. Bates ER, Lau WC, Angiolillo DJ. Clopidogrel-drug interactions. J Am Coll Cardiol 2011; 57: 1251-63
31. Hall R, Mazer CD. Antiplatelet drugs: a review of their pharmacology and management in the perioperative period. Anesth Analg 2011; 112: 292-318
32. Ho PM, Peterson ED, Wang L, et al. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. J Am Med Assoc 2008; 299: 532-9
33. Akowah E, Shrivastava V, Jamnadas B, et al. Comparison of two strategies for the management of antiplatelet therapy during urgent surgery. Ann Thorac Surg 2005; 80: 149-52
34. Butler K, Teng R. Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers. Br J Clin Pharmacol 2010; 70: 65-77