P53 inhibits adeno-associated viral vector integration

Human Gene Therapy

Volumn 22, Issue 11, 2011, Pages 1445-1451

  Zacharias, Jeana ^a   Romanova, Liudmila G ^a   Menk, Jeremiah ^b   Philpott, Nicola J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; HELICASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARVOVIRUS VECTOR; PROTEIN P53;

ARTICLE; CANCER CELL; CELL TRANSFORMATION; CHROMOSOME 19; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; VIRUS DNA CELL DNA INTERACTION; WESTERN BLOTTING;

DEPENDOVIRUS; GENETIC VECTORS; HCT116 CELLS; HELA CELLS; HUMANS; TUMOR SUPPRESSOR PROTEIN P53; VIRUS INTEGRATION;

EID: 81855216430     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2011.006     Document Type: Article

References (37)

1. Batchu, R.B., Shammas, M.A., Wang, J.Y., and Munshi, N.C. (1999). Interaction of adeno-associated virus Rep78 with p53:-implications in growth inhibition. Cancer Res. 59, 3592-3595. (Pubitemid 29381858)
2. Berns, K.I., and Linden, R.M. (1995). The cryptic life style of-adeno-associated virus. Bioessays 17, 237-245.
3. Bunz, F., Dutriaux, A., Lengauer, C., et al. (1998). Requirement-for p53 and p21 to sustain G2 arrest after DNA damage. Science-282, 1497-1501. (Pubitemid 28538613)
4. Chiorini, J.A., Wendtner, C.M., Urcelay, E., et al. (1995). Highefficiency-transfer of the T cell co-stimulatory molecule B7-2 to-lymphoid cells using high-titer recombinant adeno-associated-virus vectors. Hum. Gene Ther. 6, 1531-1541. (Pubitemid 26014565)
5. Dyall, J., and Berns, K.I. (1998). Site-specific integration of adenoassociated-virus into an episome with the target locus via a-deletion-substitution mechanism. J. Virol. 72, 6195-6198. (Pubitemid 28283415)
6. Dyall, J., Szabo, P., and Berns, K.I. (1999). Adeno-associated-virus (AAV) site-specific integration: formation of AAVAAVS1-junctions in an in vitro system. Proc. Natl. Acad. Sci. U.S.A. 96, 12849-12854. (Pubitemid 29513591)
7. Fattah, F.J., Lichter, N.F., Fattah, K.R., et al. (2008). Ku70, an-essential gene, modulates the frequency of rAAV-mediated-gene targeting in human somatic cells. Proc. Natl. Acad. Sci. U.S.A. 105, 8703-8708. (Pubitemid 351987744)
8. Giraud, C., Winocour, E., and Berns, K.I. (1994). Site-specific- integration by adeno-associated virus is directed by a cellular-DNA sequence. Proc. Natl. Acad. Sci. U.S.A. 91, 10039-10043. (Pubitemid 24311944)
9. Grimm, D., Kern, A., Rittner, K., and Kleinschmidt, J.A. (1998). Novel tools for production and purification of recombinant-adenoassociated virus vectors. Hum. Gene Ther. 9, 2745-2760. (Pubitemid 29027018)
10. Halbert, C.L., Alexander, I.E., Wolgamot, G.M., and Miller, A.D. (1995). Adeno-associated virus vectors transduce primary-cells much less efficiently than immortalized cells. J. Virol. 69,-1473-1479.
11. Kotin, R.M., Siniscalco, M., Samulski, R.J., et al. (1990). Sitespecific-integration by adeno-associated virus. Proc. Natl. Acad. Sci. U.S.A. 87, 2211-2215.
12. Lamartina, S., Roscilli, G., Rinaudo, D., et al. (1998). Lipofection-of purified adeno-associated virus Rep68 protein: toward-a chromosome-targeting nonviral particle. J. Virol. 72, 7653-7658. (Pubitemid 28377905)
13. Linden, R.M., Ward, P., Giraud, C., et al. (1996a). Site-specific- integration by adeno-associated virus. Proc. Natl. Acad. Sci. U.S.A. 93, 11288-11294.
14. Linden, R.M., Winocour, E., and Berns, K.I. (1996b). The recombination-signals for adeno-associated virus site-specific-integration. Proc. Natl. Acad. Sci. U.S.A. 93, 7966-7972.
15. Malanga, M., Pleschke, J.M., Kleczkowska, H.E., and Althaus,-F.R. (1998). Poly(ADP-ribose) binds to specific domains of-p53 and alters its DNA binding functions. J. Biol. Chem. 273,-11839-11843. (Pubitemid 28272089)
16. Miller, S.A., Dykes, D.D., and Polesky, H.F. (1988). A simple-salting out procedure for extracting DNA from human nucleated-cells. Nucleic Acids Res. 16, 1215.
17. Philpott, N.J., Giraud-Wali, C., Dupuis, C., et al. (2002a). Efficient-integration of recombinant adeno-associated virus DNA vectors-requires a p5-rep sequence in cis. J. Virol. 76, 5411-5421. (Pubitemid 34517892)
18. Philpott, N.J., Gomos, J., Berns, K.I., and Falck-Pedersen, E. (2002b). A p5 integration efficiency element mediates Repdependent-integration into AAVS1 at chromosome 19. Proc. Natl. Acad. Sci. U.S.A. 99, 12381-12385.
19. Philpott, N.J., Gomos, J., and Falck-Pedersen, E. (2004). Transgene-expression after rep-mediated site-specific integration-into chromosome 19. Hum. Gene Ther. 15, 47-61. (Pubitemid 38147188)
20. Riley, T., Sontag, E., Chen, P., and Levine, A. (2008). Transcriptional-control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9, 402-412.
21. Samulski, R.J., Zhu, X., Xiao, X., et al. (1991). Targeted integration-of adeno-associated virus (AAV) into human chromosome-19. EMBO J. 10, 3941-3950. (Pubitemid 21905423)
22. Schmidt, M., Afione, S., and Kotin, R.M. (2000). Adenoassociated-virus type 2 Rep78 induces apoptosis through-caspase activation independently of p53. J. Virol. 74, 9441-9450.
23. Schnepp, B.C., Jensen, R.L., Chen, C.L., et al. (2005). Characterization-of adeno-associated virus genomes isolated from-human tissues. J. Virol. 79, 14793-14803. (Pubitemid 41636277)
24. Song, S., Lu, Y., Choi, Y.K., et al. (2004). DNA-dependent PK-inhibits adeno-associated virus DNA integration. Proc. Natl. Acad. Sci. U.S.A. 101, 2112-2116. (Pubitemid 38229023)
25. Srivastava, A. (1987). Replication of the adeno-associated virus-DNA termini in vitro. Intervirology 27, 138-147. (Pubitemid 17134706)
26. Srivastava, A., Lusby, E.W., and Berns, K.I. (1983). Nucleotide-sequence and organization of the adeno-associated virus 2-genome. J. Virol. 45, 555-564. (Pubitemid 13225420)
27. Surosky, R.T., Urabe, M., Godwin, S.G., et al. (1997). Adenoassociated-virus Rep proteins target DNA sequences to a unique-locus in the human genome. J. Virol. 71, 7951-7959. (Pubitemid 27391747)
28. Tan, I., Ng, C.H., Lim, L., and Leung, T. (2001). Phosphorylation-of a novel myosin binding subunit of protein phosphatase 1-reveals a conserved mechanism in the regulation of actin cytoskeleton. J. Biol. Chem. 276, 21209-21216.
29. Urcelay, E., Ward, P., Wiener, S.M., et al. (1995). Asymmetric replication-in vitro from a human sequence element is dependent on-adeno-associated virus Rep protein. J. Virol. 69, 2038-2046.
30. Vaziri, H., West, M.D., Allsopp, R.C., et al. (1997). ATMdependent-telomere loss in aging human diploid fibroblasts-and DNA damage lead to the post-translational activation of-p53 protein involving poly(ADP-ribose) polymerase. EMBO J. 16, 6018-6033. (Pubitemid 27427297)
31. Walsh, C.E., Liu, J.M., Xiao, X., et al. (1992). Regulated high level-expression of a human gamma-globin gene introduced into-erythroid cells by an adeno-associated virus vector. Proc. Natl. Acad. Sci. U.S.A. 89, 7257-7261.
32. Weitzman, M.D., Kyostio, S.R., Kotin, R.M., and Owens, R.A. (1994). Adeno-associated virus (AAV) Rep proteins mediate-complex formation between AAV DNA and its integration site-in human DNA. Proc. Natl. Acad. Sci. U.S.A. 91, 5808-5812. (Pubitemid 24188231)
33. Wesierska-Gadek, J., Bugajska-Schretter, A., and Cerni, C. (1996). ADP-ribosylation of p53 tumor suppressor protein: mutant but-not wild-type p53 is modified. J. Cell. Biochem. 62, 90-101. (Pubitemid 26286285)
34. Xiao, X., Li, J., and Samulski, R.J. (1996). Efficient long-term gene-transfer into muscle tissue of immunocompetent mice by-adeno-associated virus vector. J. Virol. 70, 8098-8108. (Pubitemid 26339120)
35. Yang, C.C., Xiao, X., Zhu, X., et al. (1997). Cellular recombination-pathways and viral terminal repeat hairpin structures are-sufficient for adeno-associated virus integration in vivo and-in vitro. J. Virol. 71, 9231-9247. (Pubitemid 27492365)
36. Young, S.M., Jr., and Samulski, R.J. (2001). Adeno-associated-virus (AAV) site-specific recombination does not require a-Rep-dependent origin of replication within the AAV terminal-repeat. Proc. Natl. Acad. Sci. U.S.A. 98, 13525-13530. (Pubitemid 33115931)
37. Young, S.M., Jr., McCarty, D.M., Degtyareva, N., and Samulski,-R.J. (2000). Roles of adeno-associated virus Rep protein and-human chromosome 19 in site-specific recombination. J. Virol. 74, 3953-3966. (Pubitemid 30214400)