TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

Investigational New Drugs

Volumn 28, Issue 6, 2010, Pages 825-833

  Schultze, Alexander ^a   Decker, Sebastian ^a   Otten, Jasmin ^a   Horst, Andrea Kristina ^a   Vohwinkel, Gabi ^a   Schuch, Gunter ^a   Bokemeyer, Carsten ^a   Loges, Sonja ^a   Fiedler, Walter ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Angiogenesis; EPC; Focal adhesion kinase; OEC; TAE226; Vasculogenesis

Indexed keywords

2 [5 CHLORO 2 (2 METHOXY 4 MORPHOLINOANILINO) 4 PYRIMIDINYLAMINO] N METHYLBENZAMIDE; CD133 ANTIGEN; EVEROLIMUS; FOCAL ADHESION KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HT29; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MICROVASCULATURE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; STEM CELL; SUBCUTANEOUS TISSUE TUMOR; TUMOR VASCULARIZATION;

ANIMALS; BLOOD VESSELS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL CELLS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; MICE; MICE, SCID; MORPHOLINES; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; ORGANOGENESIS; PROTEIN KINASE INHIBITORS; SIROLIMUS;

EID: 78549242679     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9326-5     Document Type: Article

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