Cell signalling: MTOR targets its own inhibitor

Nature Reviews Molecular Cell Biology

Volumn 12, Issue 12, 2011, Pages 769-

  Wrighton, Katharine H ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; F BOX PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEASOME; UBIQUITIN PROTEIN LIGASE E3;

AUTOPHAGY; CANCER CELL; MASS SPECTROMETRY; NOTE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION;

EID: 81855207237     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm3229     Document Type: Note

References (4)

1. Gao, D. et al. mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR. Mol. Cell 44, 290-303 (2011)
2. Zhao, Y., Xiong, X. & Sun, Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCFβTrCP E3 ubiquitin ligase and regulates survival and autophagy. Mol. Cell 44, 304-316 (2011)
3. Duan, S. et al. mTOR generates an auto-amplification loop by triggering the βTrCP-and CK1α-dependent degradation of DEPTOR. Mol. Cell 44, 317-324 (2011)
4. Zoncu, R., Efeyan, A. & Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev. Mol. Cell Biol. 12, 21-35 (2011)