Downregulation of alpha-fetoprotein expression by LHX4: A critical role in hepatocarcinogenesis

Carcinogenesis

Volumn 32, Issue 12, 2011, Pages 1815-1823

  Hung, Tzu Min ^a,b   Hu, Rey Heng ^a   Ho, Cheng Maw ^a   Chiu, Ya Lun ^a   Lee, Jia Ling ^a   Jeng, Yung Ming ^a   Shih, Daniel Tzu Bi ^c   Lee, Po Huang ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b E DA HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LHX4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BINDING SITE; CANCER GROWTH; CANCER PATIENT; CANCER SURGERY; CANCER TISSUE; CELL PROLIFERATION; COMPUTER MODEL; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER DEVELOPMENT; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RETROSPECTIVE STUDY; STABLE TRANSFECTION; TRANSIENT TRANSFECTION; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

AGED; ALPHA-FETOPROTEINS; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIM-HOMEODOMAIN PROTEINS; LIVER NEOPLASMS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 81855206562     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr219     Document Type: Article

References (32)

1. Parkin, D.M. et al. (2005) Global cancer statistics, 2002. CA Cancer J. Clin., 55, 74-108.
2. Anzola, M. (2004) Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesis. J. Viral Hepat., 11, 383-393.
3. Blum, H. (2005) Hepatocellular carcinoma: therapy and prevention. World J. Gastroenterol., 11, 7391-7400.
4. Whittaker, S. et al. (2010) The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene, 29, 4989-5005.
5. Aravalli, R.N. et al. (2008) Molecular mechanisms of hepatocellular carcinoma. Hepatology, 48, 2047-2063.
6. Hobert, O. et al. (2000) Functions of LIM-homeobox genes. Trends Genet., 16, 75-83.
7. Li, H. et al. (1994) Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival. EMBO J., 13, 2876-2885.
8. Liu, Y. et al. (2002) cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Brain Res., 928, 147-155.
9. Machinis, K. et al. (2001) Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. Am. J. Hum. Genet., 69, 961-968.
10. Raetzman, L.T. et al. (2002) Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development, 129, 4229-4239.
11. Kawamata, N. et al. (2002) A novel chromosomal translocation t(1;14) (q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4. Oncogene, 21, 4983-4991.
12. Yamaguchi, M. et al. (2003) Aberrant expression of the LHX4 LIMhomeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis. Genes Chromosomes Cancer, 38, 269-273.
13. Rauch, T. et al. (2006) MIRA-assisted microarray analysis, a new technology for the determination of DNA methylation patterns, identifies frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res., 66, 7939-7947.
14. Farinati, F. et al. (2006) Diagnostic and prognostic role of alphafetoprotein in hepatocellular carcinoma: both or neither? Am. J. Gastroenterol., 101, 524-532.
15. Tilghman, S.M. (1985) The structure and regulation of the alpha-fetoprotein and albumin genes. Oxf. Surv. Eukaryot. Genes, 2, 160-206.
16. Loots, G.G. et al. (2002) rVista for comparative sequence-based discovery of functional transcription factor binding sites. Genome Res., 12, 832-839.
17. Machinis, K. et al. (2005) Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects. J. Clin. Endocrinol. Metab., 90, 5456-5462.
18. Pinto, D. et al. (2005) Wnt control of stem cells and differentiation in the intestinal epithelium. Exp. Cell Res., 306, 357-363.
19. Li, M.S. et al. (2002) The promoting molecular mechanism of alphafetoprotein on the growth of human hepatoma Bel7402 cell line. World J. Gastroenterol., 8, 469-475.
20. Li, M. et al. (2009) Alpha fetoprotein is a novel protein-binding partner for caspase-3 and blocks the apoptotic signaling pathway in human hepatoma cells. Int. J. Cancer, 124, 2845-2854.
21. Wu, H.K. et al. (1997) Transcriptional activation of human LIM-HOX gene, hLH-2, in chronic myelogenous leukemia is due to a cis-acting effect of Bcr-Abl. Biochem. Biophys. Res. Commun., 233, 806-812.
22. Hamada, J. et al. (2001) Overexpression of homeobox gene HOXD3 induces coordinate expression of metastasis-related genes in human lung cancer cells. Int. J. Cancer, 93, 516-525.
23. Naora, H. et al. (2001) A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells. Proc. Natl Acad. Sci. USA, 98, 4060-4065.
24. Shimoda, M. et al. (2006) A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. Clin. Cancer Res., 12, 6005-6011.
25. Abate-Shen, C. (2002) Deregulated homeobox gene expression in cancer: cause or consequence? Nat. Rev. Cancer, 2, 777-785.
26. Chawengsaksophak, K. et al. (1997) Homeosis and intestinal tumours in Cdx2 mutant mice. Nature, 386, 84-87.
27. Bowen, C. et al. (2000) Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression. Cancer Res., 60, 6111-6115.
28. Howard, P.W. et al. (2000) Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. J. Biol. Chem., 275, 13336-13342.
29. de Bruijn, D.R. et al. (2008) The C terminus of the synovial sarcomaassociated SSX proteins interacts with the LIM homeobox protein LHX4. Oncogene, 27, 653-662.
30. Mullen, R.D. et al. (2007) Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development. Mol. Cell. Endocrinol., 265-266, 190-195.
31. Chen, J. et al. (2005) The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics. Endocrinology, 146, 3985-3998.
32. Kawamata, H. et al. (2006) Differentiation-inducing therapy for solid tumors. Curr. Pharm. Des., 12, 379-385.