The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton

Biochemical Society Transactions

Volumn 39, Issue 6, 2011, Pages 1725-1728

  Noegel, Angelika A ^a   Neumann, Sascha ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

catenin; Chromatin; Laminopathy; Linker of nucleoskeleton and cytoskeleton complex (LINC complex); Nesprin; Wnt signalling; Wound healing

Indexed keywords

EMERIN; LAMIN A; LAMIN C; NESPRIN 2 PROTEIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CONFERENCE PAPER; CYTOPLASM; CYTOSKELETON; EMERY DREIFUSS MUSCULAR DYSTROPHY; IN VIVO STUDY; MOUSE; MYOPATHY; NONHUMAN; PRIORITY JOURNAL; PROGERIA; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WOUND HEALING;

ANIMALS; CELL NUCLEUS; CYTOSKELETON; DISEASE; HUMANS; LAMINS; MEMBRANE PROTEINS; PROTEIN BINDING;

EID: 81855198181     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110668     Document Type: Conference Paper

References (27)

1. Rivero, F., Kuspa, A., Brokamp, R., Matzner, M. and Noegel, A.A. (1998) Interaptin, an actin-binding protein of the α-actinin superfamily in Dictyostelium discoideum, is developmentally and cAMP-regulated and associates with intracellular membrane compartments. J. Cell Biol. 142, 735-750 (Pubitemid 28381491)
2. Shimanuki, M., Miki, F., Ding, D.Q., Chikashige, Y., Hiraoka, Y., Horio, T. and Niwa, O. (1997) A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architecture. Mol. Gen. Genet. 254, 238-249
3. Starr, D.A. and Fischer, J.A. (2005) KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. BioEssays 27, 1136-1146 (Pubitemid 43076140)
4. Wilhelmsen, K., Litjens, S.H., Kuikman, I., Tshimbalanga, N., Janssen, H., van den Bout, I., Raymond, K. and Sonnenberg, A. (2005) Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J. Cell Biol. 171, 799-810 (Pubitemid 41746582)
5. Roux, K.J., Crisp, M.L., Liu, Q., Kim, D., Kozlov, S., Stewart, C.L. and Burke, B. (2009) Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization. Proc. Natl. Acad. Sci. U.S.A. 106, 2194-2199
6. Djinovic-Carugo, K., Gautel, M., Ylanne, J. and Young, P. (2002) The spectrin repeat: a structural platform for cytoskeletal protein assemblies. FEBS Lett. 513, 119-123 (Pubitemid 34242988)
7. Simpson, J.G. and Roberts, R.G. (2008) Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms. Biochem. Soc. Trans. 36, 1359-1367
8. Padmakumar, V.C., Libotte, T., Lu, W., Zaim, H., Abraham, S., Noegel, A.A., Gotzmann, J., Foisner, R. and Karakesisoglou, I. (2005) The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. J. Cell Sci. 118, 3419-3430 (Pubitemid 41246097)
9. Starr, D.A. and Fridolfsson, H.N. (2010) Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu. Rev. Cell Dev. Biol. 26, 421-444
10. Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D.K., Solimando, L. and Goldman, R.D. (2008) Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin. Genes Dev. 22, 832-853 (Pubitemid 351482836)
11. Bione, S., Maestrini, E., Rivella, S., Mancini, M., Regis, S., Romeo, G. and Toniolo, D. (1994) Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy. Nat. Genet. 8, 323-327 (Pubitemid 24375595)
12. Zaremba-Czogalla, M., Dubinska-Magiera, M. and Rzepecki, R. (2011) Laminopathies: the molecular background of the disease and the prospects for its treatment. Cell. Mol. Biol. Lett. 16, 114-148
13. Verstraeten, V.L., Broers, J.L., Ramaekers, F.C. and van Steensel, M.A. (2007) The nuclear envelope, a key structure in cellular integrity and gene expression. Curr. Med. Chem. 14, 1231-1248 (Pubitemid 46739324)
14. Lüke, Y., Zaim, H., Karakesisoglou, I., Jaeger, V.M., Sellin, L., Lu, W., Schneider, M., Neumann, S., Beijer, A., Munck, M. et al. (2008) Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J. Cell Sci. 121, 1887-1898 (Pubitemid 351943382)
15. Kandert, S., Luke, Y., Kleinhenz, T., Neumann, S., Lu, W., Jaeger, V.M., Munck, M., Wehnert, M., Muller, C.R., Zhou, Z. et al. (2007) Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. Hum. Mol. Genet. 16, 2944-2959 (Pubitemid 350048391)
16. Zhang, Q., Bethmann, C., Worth, N.F., Davies, J.D., Wasner, C., Feuer, A., Ragnauth, C.D., Yi, Q., Mellad, J.A., Warren, D.T. et al. (2007) Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. Hum. Mol. Genet. 16, 2816-2833 (Pubitemid 350048381)
17. Mislow, J.M., Holaska, J.M., Kim, M.S., Lee, K.K., Segura-Totten, M., Wilson, K.L. and McNally, E.M. (2002) Nesprin-1α self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 525, 135-140
18. Zhong, Z., Chang, S.A., Kalinowski, A., Wilson, K.L. and Dahl, K.N. (2010) Stabilization of the spectrin-like domains of nesprin-1α by the evolutionarily conserved "adaptive" domain. Cell. Mol. Bioeng. 3, 139-150
19. Lu, W., Gotzmann, J., Sironi, L., Jaeger, V.M., Schneider, M., Luke, Y., Uhlen, M., Szigyarto, C.A., Brachner, A., Ellenberg, J. et al. (2008) Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim. Biophys. Acta 1783, 2415-2426
20. Stewart-Hutchinson, P.J., Hale, C.M., Wirtz, D. and Hodzic, D. (2008) Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Exp. Cell Res. 314, 1892-1905
21. Postel, R., Ketema, M., Kuikman, I., de Pereda, J.M. and Sonnenberg, A. (2011) Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish. J. Cell Sci. 124, 755-764
22. Schneider, M., Lu, W., Neumann, S., Brachner, A., Gotzmann, J., Noegel, A.A. and Karakesisoglou, I. (2011) Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cell. Mol. Life Sci. 68, 1593-1610
23. Pandur, P., Maurus, D. and Kühl, M. (2002) Increasingly complex: new players enter the Wnt signaling network. BioEssays 10, 881-884 (Pubitemid 35180843)
24. Markiewicz, E., Tilgner, K., Barker, N., van de Wetering, M., Clevers, H., Dorobek, M., Hausmanowa-Petrusewicz, I., Ramaekers, F.C., Broers, J.L., Blankesteijn, W.M. et al. (2006) The inner nuclear membrane protein emerin regulates β-catenin activity by restricting its accumulation in the nucleus. EMBO J. 25, 3275-3285 (Pubitemid 44141786)
25. Neumann, S., Schneider, M., Daugherty, R.L., Gottardi, C.J., Eming, S.A., Beijer, A., Noegel, A.A. and Karakesisoglou, I. (2010) Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope. J. Biol. Chem. 285, 34932-34938
26. Schäfer, M. and Werner, S. (2007) Transcriptional control of wound repair. Annu. Rev. Cell Dev. Biol. 23, 69-92
27. Shumaker, D.K., Dechat, T., Kohlmaier, A., Adam, S.A., Bozovsky, M.R., Erdos, M.R., Eriksson, M., Goldman, A.E., Khuon, S., Collins, F.S. et al. (2006) Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl. Acad. Sci. U.S.A. 103, 8703-8708 (Pubitemid 43878083)