Frontotemporal dementia: What can the behavioral variant teach us about human brain organization?

Neuroscientist

Volumn 18, Issue 4, 2012, Pages 373-385

  Seeley, William W ^a   Zhou, Juan ^a   Kim, Eun Joo ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Pusan National University Hospital   (South Korea)

Author keywords

anterior cingulate; anterior insula; frontotemporal dementia; functional connectivity; von Economo neuron

Indexed keywords

ANGER; BRAIN DEGENERATION; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN REGION; CLINICAL DEMENTIA RATING SCALE; EMOTION; EMPATHY; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; HUMAN; MORALITY; NEUROANATOMY; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RATING SCALE; RECOGNITION; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOCIAL BEHAVIOR;

BRAIN; BRAIN MAPPING; EMOTIONS; FRONTOTEMPORAL DEMENTIA; HUMANS; MODELS, BIOLOGICAL; SOCIAL BEHAVIOR;

EID: 81855170420     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858411410354     Document Type: Review

References (79)

1. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM. The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struct Funct. 2010 ; 214 (5-6). 495-517
2. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain's default network. Neuron. 2010 ; 65 (4). 550-62
3. Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci. 2005 ; 360 (1457). 1001-13 (Pubitemid 41672861)
4. Boccardi M, Sabattoli F, Laakso MP, Testa C, Rossi R, Beltramello A. Frontotemporal dementia as a neural system disease. Neurobiol Aging. 2005 ; 26 (1). 37-44 (Pubitemid 39600589)
5. Borroni B, Brambati SM, Agosti C, Gipponi S, Bellelli G, Gasparotti R. Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia. Arch Neurol. 2007 ; 64 (2). 246-51
6. Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging. 1995 ; 16 (3). 271-284
7. Broe M, Hodges JR, Schofield E, Shepherd CE, Kril JJ, Halliday GM. Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology. 2003 ; 60 (6). 1005-11 (Pubitemid 36348937)
8. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008 ; 1124: 1-38 (Pubitemid 351506788)
9. Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, Fotenos AF. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci. 2005 ; 25 (34). 7709-17 (Pubitemid 41208641)
10. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002 ; 3 (8). 655-66 (Pubitemid 135706673)
11. Craig AD. Emotional moments across time: a possible neural basis for time perception in the anterior insula. Philos Trans R Soc Lond B Biol Sci. 2009a ; 364 (1525). 1933-42
12. Craig AD. How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci. 2009b ; 10 (1). 59-70
13. Critchley HD. Neural mechanisms of autonomic, affective, and cognitive integration. J Comp Neurol. 2005 ; 493 (1). 154-66 (Pubitemid 41636198)
14. Damasio AR The feeling of what happens: Body and emotion in the making of consciousness. New York (NY): Harcourt Brace ; 1999 :
15. Damoiseaux JS, Rombouts SA, Barkhof F, Scheltens P, Stam CJ, Smith SM. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci U S A. 2006 ; 103 (37). 13848-53 (Pubitemid 44413996)
16. Deco G, Corbetta M. The dynamical balance of the brain at rest. Neuroscientist. 2011 ; 17 (1). 107-23
17. Deco G, Jirsa V, McIntosh AR, Sporns O, Kotter R. Key role of coupling, delay, and noise in resting brain fluctuations. Proc Natl Acad Sci U S A. 2009 ; 106 (25). 10302-7
18. Dosenbach NU, Fair DA, Miezin FM, Cohen AL, Wenger KK, Dosenbach RA. Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci U S A. 2007 ; 104 (26). 11073-8 (Pubitemid 47175228)
19. Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2011 ; 23 (1). 74-82
20. Fornito A, Yucel M, Patti J, Wood SJ, Pantelis C. Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies. Schizophr Res. 2009 ; 108 (1-3). 104-13
21. Fox MD, Raichle ME. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci. 2007 ; 8 (9). 700-11 (Pubitemid 47283145)
22. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A. 2005 ; 102 (27). 9673-8 (Pubitemid 40981739)
23. Gomez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci. 1996 ; 16 (14). 4491-500 (Pubitemid 26243044)
24. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF. Classification of primary progressive aphasia and its variants. Neurology. 2011 ; 76 (11). 1006-14
25. Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A. 2003 ; 100 (1). 253-8 (Pubitemid 36078061)
26. Greicius MD, Menon V. Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation. J Cogn Neurosci. 2004 ; 16 (9). 1484-92 (Pubitemid 39614250)
27. Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A. 2004 ; 101 (13). 4637-42 (Pubitemid 38437463)
28. Hakeem AY, Sherwood CC, Bonar CJ, Butti C, Hof PR, Allman JM. Von Economo neurons in the elephant brain. Anat Rec (Hoboken). 2009 ; 292 (2). 242-8
29. Heimer L, Van Hoesen GW. The limbic lobe and its output channels: implications for emotional functions and adaptive behavior. Neurosci Biobehav Rev. 2006 ; 30: 126-47 (Pubitemid 41821805)
30. Hodges JR, Patterson K. Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol. 2007 ; 6 (11). 1004-14 (Pubitemid 47562322)
31. Hof PR, Van der Gucht E. Structure of the cerebral cortex of the humpback whale, Megaptera novaeangliae (Cetacea, Mysticeti, Balaenopteridae). Anat Rec (Hoboken). 2007 ; 290 (1). 1-31 (Pubitemid 46328081)
32. Hu W, Wang Z, Lee V, Trojanowski J, Detre J, Grossman M. Distinct cerebral perfusion patterns in FTLD and AD. Neurology. 2010 ; 75 (10). 881-888
33. Hyman BT, Damasio AR, Van Hoesen GW, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 1984 ; 298: 83-95
34. Kim EJ, Sidhu M, Gaus S, Huang E, Hof PR, Miller BL Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia. Cereb Cortex ; 2011 :
35. Laxton AW, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010 ; 68 (4). 521-534
36. Mackenzie IR, Rademakers R, Neumann M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010 ; 9 (10). 995-1007
37. Matsuo K, Mizuno T, Yamada K, Akazawa K, Kasai T, Kondo M. Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography. Neuroradiology. 2008 ; 50 (7). 605-11 (Pubitemid 351904584)
38. Mendez MF, Cherrier M, Perryman KM, Pachana N, Miller BL, Cummings JL. Frontotemporal dementia versus Alzheimer's disease: differential cognitive features. Neurology. 1996 ; 47: 1189-94 (Pubitemid 26374885)
39. Mendez MF, Shapira JS. Altered emotional morality in frontotemporal dementia. Cogn Neuropsychiatry. 2009 ; 14 (3). 165-79
40. Mesulam MM, Mufson EJ. Insula of the old world monkey: III. Efferent cortical output and comments on function. J Comp Neurol. 1982 ; 212 (1). 38-52 (Pubitemid 13208308)
41. Meyer-Lindenberg A, Mervis CB, Berman KF. Neural mechanisms in Williams syndrome: a unique window to genetic influences on cognition and behaviour. Nat Rev Neurosci. 2006 ; 7 (5). 380-93
42. Miller BL, Cummings J, Mishkin F, Boone K, Prince F, Ponton M. Emergence of artistic talent in frontotemporal dementia. Neurology. 1998 ; 51 (4). 978-82 (Pubitemid 28473387)
43. Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, Han LY. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Ann Neurol. 2002 ; 51 (2). 182-9 (Pubitemid 34111440)
44. Moll J, Zahn R, de Oliveira-Souza R, Bramati IE, Krueger F, Tura B. Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia. Neuroimage. 2011 ; 54 (2). 1735-42
45. Ngowyang G. Beschreibung einer Art von Spezialzellen in der Inselrinde-zugleich Bemerkungen über die v. Economoschen Spezialzellen. J Psychol Neurol. 1932 ; 44: 671-4
46. Ngowyang G. Neuere Befunde über die Gabelzellen. Zschr Zellforsch Mikrosk Anat. 1936 ; 25: 236-9
47. Nimchinsky EA, Gilissen E, Allman JM, Perl DP, Erwin JM, Hof PR. A neuronal morphologic type unique to humans and great apes. Proc Natl Acad Sci U S A. 1999 ; 96 (9). 5268-73 (Pubitemid 29214572)
48. Omar R, Henley SM, Bartlett JW, Hailstone JC, Gordon E, Sauter DA. The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. Neuroimage. 2011 ; 56 (3). 1814-21
49. Ongur D, Price JL. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb Cortex. 2000 ; 10 (3). 206-19 (Pubitemid 30159289)
50. Penney JB, Young AB. Speculations on the functional anatomy of basal ganglia disorders. Annu Rev Neurosci. 1983 ; 6: 73-94 (Pubitemid 13101459)
51. Piguet O, Hornberger M, Mioshi E, Hodges JR. Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management. Lancet Neurol. 2010 ; 10 (2). 162-72
52. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A. 2001 ; 98 (2). 676-82 (Pubitemid 32105102)
53. Rankin KP, Gorno-Tempini ML, Allison SC, Stanley CM, Glenn S, Weiner MW. Structural anatomy of empathy in neurodegenerative disease. Brain. 2006 ; 129 (Pt 11). 2945-56 (Pubitemid 44684515)
54. Rose M. Die inselrinde des menschen und der tiere. J Psychol Neurol. 1928 ; 37: 468-624
55. Rosen HJ, Wilson MR, Schauer GF, Allison S, Gorno-Tempini ML, Pace-Savitsky C. Neuroanatomical correlates of impaired recognition of emotion in dementia. Neuropsychologia. 2006 ; 44 (3). 365-73 (Pubitemid 41821898)
56. Santos M, Uppal N, Butti C, Wicinski B, Schmeidler J, Giannakopoulos P von Economo neurons in autism: a stereologic study of the frontoinsular cortex in children. Brain Res ; 2011 1380: 206-17.
57. Saper CB. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu Rev Neurosci. 2002 ; 25: 433-69 (Pubitemid 34748024)
58. Schroeter ML, Raczka K, Neumann J, von Cramon DY. Neural networks in frontotemporal dementia: a meta-analysis. Neurobiol Aging. 2008 ; 29 (3). 418-26 (Pubitemid 351215583)
59. Seeley WW. Selective functional, regional, and neuronal vulnerability in frontotemporal dementia. Curr Opin Neurol. 2008 ; 21 (6). 701-7
60. Seeley WW. Anterior insula degeneration in frontotemporal dementia. Brain Struct Funct. 2010 ; 214 (5-6). 465-75
61. Seeley WW, Allman JM, Carlin DA, Crawford RK, Macedo MN, Greicius MD. Divergent social functioning in behavioral variant frontotemporal dementia and Alzheimer disease: reciprocal networks and neuronal evolution. Alzheimer Dis Assoc Disord. 2007 ; 21 (4). S50-7
62. Seeley WW, Carlin DA, Allman JM, Macedo MN, Bush C, Miller BL. Early frontotemporal dementia targets neurons unique to apes and humans. Ann Neurol. 2006 ; 60 (6). 660-7 (Pubitemid 46048483)
63. Seeley WW, Crawford R, Rascovsky K, Kramer JH, Weiner M, Miller BL. Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Arch Neurol. 2008 ; 65 (2). 249-55 (Pubitemid 351240789)
64. Seeley WW, Crawford RK, Zhou J, Miller BL, Greicius MD. Neurodegenerative diseases target large-scale human brain networks. Neuron. 2009 ; 62 (1). 42-52
65. Seeley WW, Matthews BR, Crawford RK, Gorno-Tempini ML, Foti D, Mackenzie IR. Unravelling Bolero: progressive aphasia, transmodal creativity and the right posterior neocortex. Brain. 2008 ; 131 (Pt 1). 39-49
66. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007 ; 27 (9). 2349-56 (Pubitemid 46340968)
67. Seeley WW, Merkle F, Gaus S, Craig AD, Allman JM, Hof PR Anterior cingulate and frontoinsular cortex: a historical perspective. Cereb Cortex ; 2011 :
68. Sollberger M, Stanley CM, Wilson SM, Gyurak A, Beckman V, Growdon M. Neural basis of interpersonal traits in neurodegenerative diseases. Neuropsychologia. 2009 ; 47 (13). 2812-27
69. Sturm VE, Ascher EA, Miller BL, Levenson RW. Diminished self-conscious emotional responding in frontotemporal lobar degeneration patients. Emotion. 2008 ; 8 (6). 861-9
70. Sturm VE, McCarthy ME, Yun I, Madan A, Yuan JW, Holley S.R. Mutual gaze in Alzheimer's disease, frontotemporal and semantic dementia couples. Soc Cogn Affect Neurosci. 2010 ;:
71. Sturm VE, Rosen HJ, Allison S, Miller BL, Levenson RW. Self-conscious emotion deficits in frontotemporal lobar degeneration. Brain. 2006 ; 129 (Pt 9). 2508-16 (Pubitemid 44522134)
72. Sturm VE, Sollberger M, Seeley WW, Rankin KP, Rosen HJ, Miller BL.. Presented at the 63rd annual meeting of the American Academy of Neurology ; 2011 Honolulu, HI ; 2011..
73. Treffert DA. The savant syndrome: an extraordinary condition. A synopsis: past, present, future. Philos Trans R Soc Lond B Biol Sci. 2009 ; 364 (1522). 1351-7
74. Viskontas IV, Boxer AL, Fesenko J, Matlin A, Heuer HW, Mirsky J. Visual search patterns in semantic dementia show paradoxical facilitation of binding processes. Neuropsychologia. 2011 ; 49 (3). 468-78
75. von Economo C. Eine neue Art Spezialzellen des Lobus cinguli und Lobus insulae. Z Ges Neurol Psychiatr. 1926 ; 100: 706-12
76. von Economo C, Koskinas GN Die Cytoarchitektonik der Hirnrinde des Erwachsenen Menschen. Berlin: Springer ; 1925 :
77. Wilson SM, Dronkers NF, Ogar JM, Jang J, Growdon ME, Agosta F. Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia. J Neurosci. 2010 ; 30 (50). 16845-54
78. Zhang Y, Schuff N, Du AT, Rosen HJ, Kramer JH, Gorno-Tempini ML. White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain. 2009 ; 132 (Pt 9). 2579-92
79. Zhou J, Greicius MD, Gennatas ED, Growdon ME, Jang JY, Rabinovici GD. Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer's disease. Brain. 2010 ; 133 (5). 1352-67