A frameshift mutation of the pro-apoptotic VDAC1 gene in cancers with microsatellite instability

Gut and Liver

Volumn 5, Issue 4, 2011, Pages 548-549

  Yoo, Nam Jin ^a   Park, Sang Wook ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; VOLTAGE DEPENDENT ANION CHANNEL 1;

APOPTOSIS; CANCER STAGING; CELL DEATH; CELL PERMEABILIZATION; COLORECTAL CANCER; DATA BASE; DNA SEQUENCE; FETUS DEVELOPMENT; FRAMESHIFT MUTATION; HUMAN; LETTER; MICROSATELLITE INSTABILITY; MITOCHONDRIAL MEMBRANE; POLYMERASE CHAIN REACTION; STOMACH CANCER;

EID: 81855167838     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2011.5.4.548     Document Type: Letter

References (8)

1. Reed JC. Mechanisms of apoptosis. Am J Pathol 2000;157:1415-1430.
2. Lee SH, Shin MS, Park WS, et al. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene 1999;18:3754-3760. (Pubitemid 29338508)
3. Kim HS, Lee JW, Soung YH, et al. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003;125:708-715. (Pubitemid 37070689)
4. Shoshan-Barmatz V, De Pinto V, Zweckstetter M, Raviv Z, Keinan N, Arbel N. VDAC, a multi-functional mitochondrial protein regulating cell life and death. Mol Aspects Med 2010;31:227-285.
5. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999;399:483-487. (Pubitemid 29258855)
6. Imai K, Yamamoto H. Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 2008;29:673-680. (Pubitemid 351494153)
7. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-5257.
8. Mader A, Abu-Hamad S, Arbel N, Gutiérrez-Aguilar M, Shoshan-Barmatz V. Dominant-negative VDAC1 mutants reveal oligomeric VDAC1 to be the active unit in mitochondria-mediated apoptosis. Biochem J 2010;429:147-155.