Evaluation of the effectiveness of Renikan: (Standardized Pelargonium sidoides extract (EPs®) 7630) in the treatment of upper respiratory tract infections of viral etiology;Evaluación de la efectividad del RENIKAN: (Extracto del pelargonium sidoides estandarizado (EPs®7630) en el tratamiento de las infecciones de las vías respiratorias superiores de etiología viral

Archivos Venezolanos de Farmacologia y Terapeutica

Volumn 30, Issue 4, 2011, Pages 79-85

  Perez G ^a   Rodriguez N ^a   Castro, H ^a   Silva, O ^a   Pabbou, D ^a   Maestracci, F ^a   Castillo, L ^a   Sifontes, M ^a   Alvarado, J ^a   Rincon A ^a   Rojas, N ^a   Quiroz, E ^a   Milano, L ^a   Petit, M ^a   Soto, G ^a   Gotera, A ^a   Rios E ^a   Chacin B ^a   Galue H ^a   Caraballo, T ^a   Flores, D ^a   Medina, Y ^a   Villalobos, S ^a   more..

^a NONE

Author keywords

Bronchitis; Pelargonium sidoides; Rhinosinusitis; Tonsillitis

Indexed keywords

ANTIBIOTIC AGENT; PELARGONIUM SIDOIDES EXTRACT; RENIKAN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRONCHITIS; CHILD; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG USE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; PRESCHOOL CHILD; RHINOSINUSITIS; SCHOOL CHILD; TONSILLITIS; UNSPECIFIED SIDE EFFECT; VIRAL UPPER RESPIRATORY TRACT INFECTION;

EID: 81755189070     PISSN: 07980264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Brent S, Saint S., Vittinghoff E., Grady D. Antibiotics in acute bronchitis a metaanalysis. Am J Med. 1999; 107: 62-67.
2. Wasserfallen JB, et al. Acute Rhinosinusitis: A Pharmacoeconomic Rewiew of Antibacterial Use. Pharmacoeconomics. 2004; 22 (13): 829-837.
3. Heinrich Matthys, Reinhard Eisebitt, Bettine Seith and Marianne Heger. Efficacy and Safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A Randonized, double -blind, placebo-controlled Trial. Phytomedicine. 2003; 10 (Supp.IV):7-17.
4. Fahey T., Howie J. Re-evaluation of randomized controlled trial of antibiotics for minor respiratory illness in general practice. Fam Pract. 2001; 18:246-248.
5. Murray S, Del Mar C, O'Rourke P. Predictors of an antibiotic prescription by GPs for respiratory tract infections: a pilot study. Fam Pract. 2000; 17:386-388.
6. Ramírez I. Uso de antimicrobianos en infecciones agudas de las vías aéreas respiratorias altas. Rev. Med. IMSS. 2005; 43(3):247-255.
7. Morales Sergio D., Gerometta Pedro H., Carrara Carolina, Valsecia Mabel. Atención primaria en salud: uso de antibióticos a nivel respiratorio en la ciudad de Corrientes. Cátedra de Farmacología. Facultad de Medicina_UNNE. Moreno 1240. Teléf.: 432902 C.P. 3400 Corrientes Argentina. smorales@med.unne.edu.ar
8. Gonzáles R, et al. Antibiotic prescribing for adults with colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians. JAMA, 1997; 278 (11); 901-4.
9. Nyquist A.C. et al. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA; 1998; 279(11): 875-7.
10. Kayser, O. and et al. Composition of the esential oils of Pelargonium sidoides DC and Pelargonium reniforme curt. Flavor and Fragr J.; 1998(13): 209-212.
11. Herbert Kolodziej, Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme tradicional and Phytomedicinal sources of the herbal medicine umckaloabo. Phytomedicine, 2007. 14 (Suppl.1): 9-17.
12. Bladt, S; Wagner, H, cumarindrogen, 1 Mitteilung: Qualitätsprüfung der Umcka Droge und ihrer Zubereitungen, DAZ 1988(128): 292-296.
13. Kiderklen AF, Kayser O, Ferreira D, Kolodziej H. Tannins and related compounds Killing of amastigotes of Leishmania donovani and release of nitric oxide and tumour necrosis factor alpha in macrophages in vitro. Znaturforsch 2001; 56:444-454.
14. Kayser, O; Kolodziej, H. Highly oxigenated coumarins from Pelargonium sidoides. Phytochemestry. 1995 (39): 1181-1185.
15. Herbert Kolodziej, Oliver Kayser, Oliver A. Radtke, Albrecht F. Kiderlen, and Egon Koch. Pharmacological profile of extrats of Pelargonium sidoides and their constituents. Phytomedicine, 2003, 10 (Supp 4):18-24. Elsevier Gmbh.WWW else vier.de/phymed.
16. ® 7630) Inhibits of group A. streptococci and host epithelia in vitro. Phytomedicine 2007; 14 (suppl 1) 52-59
17. Herbert Kolodziej, Albrecht F. Kiderlen. In vitro evaluation of antibacterial and immunomodulatory activites of pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparations EPs 7630. Phytomedicine: 2007; 14 Suppl 6:18-26.
18. Kayser, O; Kiderlen, A.F Kolodziej, H. Inhibition of luminol dependent chemiluminescence and NO release by a series of oxygenated coumarins in murine macrophages infeted with leishmania denovani. Pharmaceutical and Pharmacological Letters.1997; 7(2/3):71-74.
19. Kiderlen AF, Kaye PM. A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against leishmania parasites. J Immunol Methods. 1990.127 (1):11-18.
20. Anderson J. E., Gortz C.M., Laughlin J.L., and Suffnees, M. A blind comparison of simple bench-top bioassays and human tumor cell cytotoxites as antitumor prescreens. Phytoche. Anal. 1991; 2:107-111.
21. Zimmermann W. On the Anticoagulant Action of Umckaloabo Drugs Arsel Forsch. 1965; 19:278-80.
22. O. Kayser and H. Kolodziej. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta me. 1997; 63 (6): 508-10.
23. Herber Kolodziej Oliver Kayser, Oliver A Radtke, Albrecht F. Kiderlen, and Egon Koch. Pharmacological profile of extracts of Pelergonium sidoides and their constituents. Phytomedicine, 2003. 10 (Supp. 4):18-24. www.elsevier.de/phymed.
24. Nussler, A.K and Biliar, T. Inflamation, inmunoregulation, and inducible nitric oxide synthase. J. Leuk Biol. 1993, 54 (2):171-178.
25. Altiner A, Abholz HH. Akute Bronchitis und antibiotika. Hintergründe für eine rationale, Therapie. 2 Allg med. 2001; 77:358-362.