메뉴 건너뛰기




Volumn 18, Issue 6, 2011, Pages

Metabolic modulation: A new therapeutic target in treatment of heart failure

Author keywords

etomoxir; metabolic modulators; perhexiline; ranolazine; trimetazidine

Indexed keywords

ANTIANGINA PECTORIS AGENT; CARVEDILOL; ETOMOXIR; FATTY ACID; GLUCOSE; PERHEXILINE; PLACEBO; RANOLAZINE; TRIMETAZIDINE;

EID: 81755184785     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3181d70453     Document Type: Article
Times cited : (18)

References (37)
  • 1
    • 0028807019 scopus 로고
    • Guidelines for the evaluation and management of heart failure: Report of the american college of cardiology/american heart association task force on practice guidelines (committee on evaluation and management of heart failure)
    • Williams JF Jr, Bristow MR, Fowler MB, et al. Guidelines for the evaluation and management of heart failure: report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Evaluation and Management of Heart Failure). J Am Coll Cardiol. 1995;26:1376-1398.
    • (1995) J Am Coll Cardiol. , vol.26 , pp. 1376-1398
    • Williams Jr., J.F.1    Bristow, M.R.2    Fowler, M.B.3
  • 3
    • 0029351908 scopus 로고
    • National hospital discharge survey: Annual summary 1993: Vital and health statistics, series 13
    • Graves EJ. National Hospital Discharge Survey: Annual Summary, 1993: Vital and Health Statistics, Series 13. Natl Health Surv. 1995;121:1-63.
    • (1995) Natl Health Surv. , vol.121 , pp. 1-63
    • Graves, E.J.1
  • 4
    • 0036751370 scopus 로고    scopus 로고
    • Malonyl CoA control of fatty acid oxidation in the ischemic heart
    • DOI 10.1016/S0022-2828(02)92060-2
    • Dyck JR, Lopaschuk GD. Malonyl CoA control of fatty acid oxidation in the ischemic heart. J Mol Cell Cardiol. 2002;34:1099-1109. (Pubitemid 35205154)
    • (2002) Journal of Molecular and Cellular Cardiology , vol.34 , Issue.9 , pp. 1099-1109
    • Dyck, J.R.B.1    Lopaschuk, G.D.2
  • 5
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long- chain 3-ketoacyl coenzyme A thiolase
    • Kantor PF, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86:580-588. (Pubitemid 30165050)
    • (2000) Circulation Research , vol.86 , Issue.5 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 6
    • 0028018335 scopus 로고
    • Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation
    • DOI 10.1006/jmcc.1994.1116
    • Fantini E, Demaison L, Sentex E, et al. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol. 1994;26:949-958. (Pubitemid 24279511)
    • (1994) Journal of Molecular and Cellular Cardiology , vol.26 , Issue.8 , pp. 949-958
    • Fantini, E.1    Demaison, L.2    Sentex, E.3    Grynberg, A.4    Athias, P.5
  • 7
    • 0028264333 scopus 로고
    • Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts
    • Boucher FR, Hearse DJ, Opie LH. Effects of trimetazidine on ischemic contracture in isolated perfused rat hearts. J Cardiovasc Pharmacol. 1994;24:45-49. (Pubitemid 24189598)
    • (1994) Journal of Cardiovascular Pharmacology , vol.24 , Issue.1 , pp. 45-49
    • Boucher, F.R.1    Hearse, D.J.2    Opie, L.H.3
  • 8
    • 33847051689 scopus 로고    scopus 로고
    • Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemia-reperfusion
    • DOI 10.1016/j.trsl.2006.11.004, PII S1931524406004191
    • Ruixing Y,Wenwu L, Al-Ghazali R. Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemia reperfusion. Transl Res. 2007;149:152-160. (Pubitemid 46275573)
    • (2007) Translational Research , vol.149 , Issue.3 , pp. 152-160
    • Ruixing, Y.1    Wenwu, L.2    Al-Ghazali, R.3
  • 9
    • 0034832920 scopus 로고    scopus 로고
    • Triglycerides impair postischemic recovery in isolated rat hearts: Roles of endothelin-1 and trimetazidine
    • Monti LD, Allibardi S, Piatti PM, et al. Triglycerides impair postischemic recovery in isolated rat hearts: roles of endothelin-1 and trimetazidine. Am J Physiol Heart Circ Physiol. 2001;281:1122-1130.
    • (2001) Am J Physiol Heart Circ Physiol. , vol.281 , pp. 1122-1130
    • Monti, L.D.1    Allibardi, S.2    Piatti, P.M.3
  • 11
    • 0032189888 scopus 로고    scopus 로고
    • Effects of Trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease
    • DOI 10.1016/S0002-9149(98)00500-1, PII S0002914998005001
    • Lu C, Dabrowski P, Fragasso G, et al. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease. Am J Cardiol. 1998; 82:898-901. (Pubitemid 28467367)
    • (1998) American Journal of Cardiology , vol.82 , Issue.7 , pp. 898-901
    • Lu, C.1    Dabrowski, P.2    Fragasso, G.3    Chierchia, S.L.4
  • 12
    • 1542496389 scopus 로고    scopus 로고
    • Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy
    • Fragasso G, Piatti PM, Monti L, et al. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J. 2003;146:E18.
    • (2003) Am Heart J. , vol.146
    • Fragasso, G.1    Piatti, P.M.2    Monti, L.3
  • 14
    • 33645466318 scopus 로고    scopus 로고
    • Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
    • Fragasso G, Perseghin G, DeCobelli F, et al. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure. Eur Heart J. 2006;27: 942-948.
    • (2006) Eur Heart J. , vol.27 , pp. 942-948
    • Fragasso, G.1    Perseghin, G.2    Decobelli, F.3
  • 15
    • 53449101397 scopus 로고    scopus 로고
    • Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    • Tuunanen H, Engblom E, Naum A, et al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation. 2008;118:1250-1258.
    • (2008) Circulation. , vol.118 , pp. 1250-1258
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3
  • 16
    • 0035208524 scopus 로고    scopus 로고
    • Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy
    • DOI 10.1053/euhj.2001.2653
    • Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy. Eur Heart J. 2001;22:2164-2170. (Pubitemid 33139462)
    • (2001) European Heart Journal , vol.22 , Issue.23 , pp. 2164-2170
    • Belardinelli, R.1    Purcaro, A.2
  • 17
    • 33646140572 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of ranolazine
    • Jerling M. Clinical pharmacokinetics of ranolazine. Clin Pharmacokinet. 2006;45:469-491.
    • (2006) Clin Pharmacokinet. , vol.45 , pp. 469-491
    • Jerling, M.1
  • 18
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA, et al. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation. 1996;93:135-142. (Pubitemid 26007542)
    • (1996) Circulation , vol.93 , Issue.1 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 19
    • 40949140176 scopus 로고    scopus 로고
    • The cardiac persistent sodium current: An appealing therapeutic target?
    • DOI 10.1038/sj.bjp.0707492, PII 0707492
    • Saint DA. The cardiac persistent sodium current: an appealing therapeutic target? Br J Pharmacol. 2008;153: 1133-1142. (Pubitemid 351415490)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.6 , pp. 1133-1142
    • Saint, D.A.1
  • 20
    • 40949122385 scopus 로고    scopus 로고
    • Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium
    • DOI 10.1038/sj.bjp.0707522, PII 0707522
    • Shryock JC, Belardinelli L. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. Br J Pharmacol. 2008;153: 1128-1132. (Pubitemid 351415493)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.6 , pp. 1128-1132
    • Shryock, J.C.1    Belardinelli, L.2
  • 25
  • 27
    • 0021146282 scopus 로고
    • Impaired oxidation of debrisoquine in patients with perhexiline liver injury
    • Morgan MY, Reshef R, Shah RR, et al. Impaired oxidation of debrisoquine in patients with perhexiline liver injury. Gut. 1984;25:1057-1064. (Pubitemid 14002119)
    • (1984) Gut , vol.25 , Issue.10 , pp. 1057-1064
    • Morgan, M.Y.1    Reshef, R.2    Shah, R.R.3
  • 28
    • 0022451358 scopus 로고
    • Perhexiline maleate treatment for severe angina pectoris - Correlations with pharmacokinetics
    • DOI 10.1016/0167-5273(86)90146-4
    • Horowitz JD, Sia ST, Macdonald PS, et al. Perhexiline maleate treatment for severe angina pectoriscorrelations with pharmacokinetics. Int J Cardiol. 1986; 13:219-229. (Pubitemid 16000586)
    • (1986) International Journal of Cardiology , vol.13 , Issue.2 , pp. 219-229
    • Horowitz, J.D.1    Sia, S.T.B.2    Macdonald, P.S.3
  • 30
    • 0033653158 scopus 로고    scopus 로고
    • Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart
    • Kennedy JA, Kiosoglous AJ, Murphy GA, et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. J Cardiovasc Pharmacol. 2000;36:794-801.
    • (2000) J Cardiovasc Pharmacol. , vol.36 , pp. 794-801
    • Kennedy, J.A.1    Kiosoglous, A.J.2    Murphy, G.A.3
  • 32
    • 0023845559 scopus 로고
    • Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes
    • Reaven GM, Chang H, Hoffman BB. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes. Diabetes. 1988;37:28-32. (Pubitemid 18036453)
    • (1988) Diabetes , vol.37 , Issue.1 , pp. 28-32
    • Reaven, G.M.1    Chang, H.2    Hofman, B.B.3
  • 33
    • 0024262853 scopus 로고
    • Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine
    • Lopaschuk GD, Wall SR, Olley PM, et al. Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988;63: 1036-1043. (Pubitemid 19004258)
    • (1988) Circulation Research , vol.63 , Issue.6 , pp. 1036-1043
    • Lopaschuk, G.D.1    Wall, S.R.2    Olley, P.M.3    Davies, N.J.4
  • 34
    • 0028558371 scopus 로고
    • CPT-1 inhibition by etomoxir has a
    • chamber-related action on cardiac sarcoplasmic reticulum and isomyosins
    • Vetter R, Rupp H. CPT-1 inhibition by etomoxir has a chamber-related action on cardiac sarcoplasmic reticulum and isomyosins. Am J Physiol. 1994;267: H2091-H209.
    • (1994) Am J Physiol. , vol.267
    • Vetter, R.1    Rupp, H.2
  • 35
    • 0029814911 scopus 로고    scopus 로고
    • Modification of sarcoplasmic reticulum gene expression in pressure overload cardiac hypertrophy by etomoxir
    • Zarain-Herzberg A, Rupp H, Elimban V, et al. Modification of sarcoplasmic reticulum gene expression in pressure overload cardiac hypertrophy by etomoxir. FASEB J. 1996;10:1303-1309. (Pubitemid 26307516)
    • (1996) FASEB Journal , vol.10 , Issue.11 , pp. 1303-1309
    • Zarain-Herzberg, A.1    Rupp, H.2    Elimban, V.3    Dhalla, N.S.4
  • 36
    • 0030778603 scopus 로고    scopus 로고
    • Etomoxir improves left ventricular performance of pressure-overloaded rat heart
    • Turcani M, Rupp H. Etomoxir improves left ventricular performance of pressure-overloaded rat heart. Circulation. 1997;96:3681-3686. (Pubitemid 27513449)
    • (1997) Circulation , vol.96 , Issue.10 , pp. 3681-3686
    • Turcani, M.1    Rupp, H.2
  • 37
    • 0033910352 scopus 로고    scopus 로고
    • First clinical trial with etomoxir in patients with chronic congestive heart failure
    • Schmidt-Schweda S, Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond). 2000;99:27-35. (Pubitemid 30479390)
    • (2000) Clinical Science , vol.99 , Issue.1 , pp. 27-35
    • Schmidt-Schweda, S.1    Holubarsch, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.