A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Voorbij, Annemarie M W Y ^a   van Steenbeek, Frank G ^a   Vos Loohuis, Manon ^a   Martens, Ellen E C P ^a   Hanson Nilsson, Jeanette M ^a   van Oost, Bernard A ^b   Kooistra, Hans S ^a   Leegwater, Peter A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b American University of the Caribbean   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; BISULFITE; COMPLEMENTARY DNA; CYTOSINE; REPETITIVE DNA; RNA; TRANSCRIPTION FACTOR LHX3; URACIL; LIM HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA BINDING; DOG; EXON; GENE; GENE DELETION; GENE INSERTION; GENETIC ANALYSIS; GENETIC LINKAGE; HETEROZYGOSITY; HYPOPHYSIS; INTRON; LHX3 GENE; NONHUMAN; PITUITARY DWARFISM; PROTEIN DOMAIN; RECESSIVE INHERITANCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; SPLICING DEFECT; ANIMAL; ANIMAL DISEASE; DOG DISEASE; GENETIC PREDISPOSITION; GENETICS; GERMANY; MALE; MOLECULAR GENETICS; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE;

CANIS FAMILIARIS;

ANIMALS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; DOG DISEASES; DOGS; DWARFISM, PITUITARY; EXONS; GENETIC PREDISPOSITION TO DISEASE; GERMANY; INTRONS; LIM-HOMEODOMAIN PROTEINS; MALE; MOLECULAR SEQUENCE DATA; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA SPLICING; SEQUENCE DELETION; TRANSCRIPTION FACTORS;

EID: 81755171940     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027940     Document Type: Article

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