Effectiveness of thrombolysis with intravenous alteplase for acute ischemic stroke in older adults

Journal of the American Geriatrics Society

Volumn 59, Issue 11, 2011, Pages 2169-2171

  Dirks, Maaike ^a   Niessen, Louis W ^b,c,d   Van Wijngaarden, Jeroen D H ^b   Koudstaal, Peter J ^a   Franke, Cees L ^e   Van Oostenbrugge, Robert J ^f   Dippel, Diederik W J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e Zuyderland Medical Centre   (Netherlands)

^f MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE;

AGE; AGED; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CLINICAL EFFECTIVENESS; FEMALE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; STROKE PATIENT; TREATMENT OUTCOME;

AGED, 80 AND OVER; FIBRINOLYTIC AGENTS; HUMANS; INJECTIONS, INTRAVENOUS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 81755162271     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2011.03707.x     Document Type: Letter

References (10)

1. Wardlaw JM, Murray V, Berge E, et al. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2009; CD000213.
2. Katzan IL, Hammer MD, Hixson ED, et al. Utilization of intravenous tissue plasminogen activator for acute ischemic stroke. Arch Neurol 2004; 61: 346-350.
3. Larrue V, von Kummer R, Muller A, et al. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: A secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 2001; 32: 438-441.
4. Forster A, Szabo K, Kreisel S, et al. Thrombolysis in very old people with stroke: Stroke subtypes, patterns, complications, and clinical outcome. J Am Geriatr Soc 2011; 59: 178-180.
5. Engelter ST, Reichhart M, Sekoranja L, et al. Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology 2005; 65: 1795-1798.
6. Saposnik G, Cote R, Phillips S, et al. Stroke outcome in those over 80: A multicenter cohort study across Canada. Stroke 2008; 39: 2310-2317.
7. Mishra NK, Ahmed N, Andersen G, et al. Thrombolysis in very elderly people: Controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ 2010; 341: c6046.
8. Ford GA, Ahmed N, Azevedo E, et al. Intravenous alteplase for stroke in those older than 80 years old. stroke 2010; 41: 2568-2574.
9. Wahlgren N, Ahmed N, Davalos A, et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): An observational study. Lancet 2007; 369: 275-282.
10. Major ongoing stroke trials-Third International Stroke Trial (IST-3). Stroke 2005; 36: e160-e161.