Effect of intravitreal anti-vascular endothelial growth factor treatment on the retinal gene expression in acute experimental central retinal vein occlusion

Ophthalmic Research

Volumn 47, Issue 3, 2012, Pages 157-162

  Drechsler, Franziska ^a   Köferl, Patricia ^a   Hollborn, Margrit ^a   Wiedemann, Peter ^a   Bringmann, Andreas ^a   Kohen, Leon ^a,b   Rehak, Matus ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Helios Klinikum   (Germany)

Author keywords

Bevacizumab; Interleukin 1 ; Pigment epithelium derived factor; Rat; Retinal vein occlusion; Vascular endothelial growth factor

Indexed keywords

AQUAPORIN 1; AQUAPORIN 4; BEVACIZUMAB; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PIGMENT EPITHELIUM DERIVED FACTOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR4.1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL RETINA VEIN OCCLUSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; EYE; GENE EXPRESSION; INJECTION; LASER COAGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REAL TIME ECHOGRAPHY; RECEPTOR UPREGULATION; RETINA EDEMA; RETINA NERVE CELL; RETINA VEIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; AQUAPORINS; DISEASE MODELS, ANIMAL; EYE PROTEINS; GENE EXPRESSION REGULATION; INTERLEUKINS; INTRAVITREAL INJECTIONS; NERVE GROWTH FACTORS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RETINA; RETINAL VEIN OCCLUSION; SERPINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 81555231525     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000330279     Document Type: Article

References (26)

1. Bringmann A, Reichenbach A, Wiedemann P: Pathomechanisms of cystoid macular edema. Ophthalmic Res 2004;36:241-249. (Pubitemid 39664117)
2. Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL: Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997;46:1473-1480. (Pubitemid 27369086)
3. Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S: Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology 2003;110:1690-1696. (Pubitemid 37025424)
4. Luna JD, Chan CC, Derevjanik NL, Mahlow J, Chiu C, Peng B, Tobe T, Campochiaro PA, Vinores SA: Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: comparison with vascular endothelial growth factor, tumor necrosis factor-α, and interleukin-1β-mediated breakdown. J Neurosci Res 1997;49:268-280. (Pubitemid 27344187)
5. Zhang SX, Wang JJ, Gao G, Parke K, Ma JX: Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol 2006;37:1-12. (Pubitemid 44288601)
6. Mori F, Hikichi T, Takahashi J, Nagaoka T, Yoshida A: Dysfunction of active transport of blood-retinal barrier in patients with clinically significant macular edema in type 2 diabetes. Diabetes Care 2002;25:1248-1249.
7. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A: Müller cells in the healthy and diseased retina. Prog Retin Eye Res 2006;25:397-424. (Pubitemid 44038611)
8. Iandiev I, Pannicke T, Biedermann B, Wiedemann P, Reichenbach A, Bringmann A: Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina. Neurosci Lett 2006;408:108-112. (Pubitemid 44498950)
9. Iandiev I, Pannicke T, Reichenbach A, Wiedemann P, Bringmann A: Diabetes alters the localization of glial aquaporins in rat retina. Neurosci Lett 2007;421:132-136. (Pubitemid 46907433)
10. Pannicke T, Iandiev I, Uckermann O, Biedermann B, Kutzera F, Wiedemann P, Wolburg H, Reichenbach A, Bringmann A: A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci 2004;26:493-502. (Pubitemid 38969947)
11. Iandiev I, Tenckhoff S, Pannicke T, Biedermann B, Hollborn M, Wiedemann P, Reichenbach A, Bringmann A: Differential regulation of Kir4.1 and Kir2.1 expression in the ischemic rat retina. Neurosci Lett 2006;396:97-101. (Pubitemid 43276420)
12. Rehak M, Hollborn M, Iandiev I, Pannicke T, Karl A, Wurm A, Kohen L, Reichenbach A, Wiedemann P, Bringmann A: Retinal gene expression and Müller cell responses after branch retinal vein occlusion in the rat. Invest Ophthalmol Vis Sci 2009;50:2359-2367.
13. Cekiç O, Cakir M, Yazici AT, Alagöz N, Bozkurt E, Faruk Y?lmaz O: A comparison of three different intravitreal treatment modalities of macular edema due to branch retinal vein occlusion. Curr Eye Res 2010;35:925-929.
14. Rouvas A, Petrou P, Ntouraki A, Douvali M, Ladas I, Vergados I: Intravitreal ranibizumab (Lucentis) for branch retinal vein occlusion-induced macular edema: nine-month results of a prospective study. Retina 2010;30:893-902.
15. Hoeh AE, Ach T, Schaal KB, Scheuerle AF, Dithmar S: Long-term follow-up of OCT-guided bevacizumab treatment of macular edema due to retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2009;247:1635-1641.
16. Rehak M, Drechsler F, Köferl P, Hollborn M, Wiedemann P, Bringmann A, Kohen L: Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2011;249:1175-1183.
17. Vinores SA, Xiao WH, Zimmerman R, Whitcup SM, Wawrousek EF: Upregulation of vascular endothelial growth factor (VEGF) in the retinas of transgenic mice overexpressing interleukin-1beta (IL-1beta) in the lens and mice undergoing retinal degeneration. Histol Histopathol 2003;18:797-810. (Pubitemid 36773225)
18. Watanabe K, Zhang XY, Kitagawa K, Yunoki T, Hayashi A: The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19). Graefes Arch Clin Exp Ophthalmol 2009;247:207-213.
19. Kim IB, Lee EJ, Oh SJ, Park CB, Pow DV, Chun MH: Light and electron microscopic analysis of aquaporin 1-like-immunoreactive amacrine cells in the rat retina. J Comp Neurol 2002;452:178-191.
20. Iandiev I, Pannicke T, Reichel MB, Wiedemann P, Reichenbach A, Bringmann A: Expression of aquaporin-1 immunoreactivity by photoreceptor cells in the mouse retina. Neurosci Lett 2005;388:96-99. (Pubitemid 41206739)
21. Kim KJ, Li B, Houck K, Winer J, Ferrara N: The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 1992;7:53-64.
22. Hoffart L, Matonti F, Conrath J, Daniel L, Ridings B, Masson GS, Chavane F: Inhibition of corneal neovascularization after alkali burn: comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. Clin Experiment Ophthalmol 2010;38:346-352.
23. Ma J, Zhu T, Tang X, Ye P, Zhang Z: Effect of an intravitreal injection of bevacizumab on the expression of VEGF and CD34 in the retina of diabetic rats. Clin Experiment Ophthalmol 2010;38:875-884.
24. Lu F, Adelman RA: Are intravitreal bevacizumab and ranibizumab effective in a rat model of choroidal neovascularization? Graefes Arch Clin Exp Ophthalmol 2009;247:171-177.
25. Yu L, Wu X, Cheng Z, Lee CV, LeCouter J, Campa C, Fuh G, Lowman H, Ferrara N: Interaction between bevacizumab and murine VEGF-A: a reassessment. Invest Ophthalmol Vis Sci 2008;49:522-527.
26. Hollborn M, Tenckhoff S, Seifert M, Köhler S, Wiedemann P, Bringmann A, Kohen L: Human retinal epithelium produces and responds to placenta growth factor. Graefes Arch Clin Exp Ophthalmol 2006;244:732-741. (Pubitemid 43923196)