Transient lower esophageal sphincter relaxation pharmacokinetic- pharmacodynamic modeling: Count model and repeated time-to-event model

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 3, 2011, Pages 878-885

  Plan, Elodie L ^a   Ma, Guangli ^a,b   Nag̊ar̊d, Mats ^c   Jensen, Jor̈gen ^c   Karlsson, Mats O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b PFIZER INC   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; PLACEBO;

ANIMAL EXPERIMENT; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; LOWER ESOPHAGUS SPHINCTER; MALE; MODEL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; REPEATED TIME TO EVENT MODEL; TRANSIENT LOWER ESOPHAGEAL SPHINCTER RELAXATION;

ANIMALS; BENZOXAZINES; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; DOGS; ESOPHAGEAL SPHINCTER, LOWER; FEMALE; GASTROESOPHAGEAL REFLUX; MALE; MODELS, BIOLOGICAL; MORPHOLINES; MUSCLE RELAXATION; NAPHTHALENES; PRESSURE; RECEPTORS, CANNABINOID; TIME FACTORS;

EID: 81555204257     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.181636     Document Type: Article

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