Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel

Cytokine

Volumn 56, Issue 3, 2011, Pages 564-572

  Shindo, Hisakazu ^a   Yasui, Kiyoshi ^a   Yamamoto, Kazuo ^a,b   Honma, Kiri ^a   Yui, Katsuyuki ^a   Kohno, Tomoko ^a   Ma, Yuhua ^a   Chua, Koon Jiew ^a   Kubo, Yoshinao ^a   Aihara, Hitoshi ^a   Ito, Takashi ^a   Nagayasu, Takeshi ^a   Matsuyama, Toshifumi ^a   Hayashi, Hideki ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b Campbell Family Institute for Cancer Research   (Canada)

Author keywords

Adult T cell leukemia lymphoma (ATLL); C Rel; IL 2; IL 4; Interferon regulatory factor (IRF) 4

Indexed keywords

INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 2; INTERLEUKIN 4; RNA; TRANSCRIPTION FACTOR REL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOPRECIPITATION; IN VIVO STUDY; INTERLEUKIN 2 GENE; INTERLEUKIN 4 GENE; MOUSE; NK T CELL LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; T CELL LEUKEMIA; T LYMPHOCYTE ACTIVATION; TANDEM MASS SPECTROMETRY;

ANIMALS; BINDING SITES; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTORS; INTERLEUKIN-2; INTERLEUKIN-4; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-REL;

HUMAN T-LYMPHOTROPIC VIRUS 1; MUS;

EID: 81455158868     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.08.014     Document Type: Article

References (32)

1. Savitsky D., Tamura T., Yanai H., Taniguchi T. Regulation of immunity and oncogenesis by the IRF transcription factor family. Cancer Immunol Immunother 2010, 59:489-510.
2. Matsuyama T., Grossman A., Mittrucker H.W., et al. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res 1995, 23:2127-2136.
3. Eisenbeis C.F., Singh H., Storb U. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev 1995, 9:1377-1387.
4. Yamagata T., Nishida J., Tanaka S., et al. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes. Mol Cell Biol 1996, 16:1283-1294.
5. Mittrucker H.W., Matsuyama T., Grossman A., et al. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science 1997, 275:540-543.
6. Brass A.L., Zhu A.Q., Singh H. Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimmers. EMBO J 1999, 18:977-991.
7. Shaffer A.L., Emre N.C., Romesser P.B., Staudt L.M. IRF4: Immunity. Malignancy! Therapy?. Clin Cancer Res 2009, 15:2954-2961.
8. Shaffer A.L., Emre N.C., Lamy L., et al. IRF4 addiction in multiple myeloma. Nature 2008, 454:226-231.
9. Rengarajan J., Mowen K., McBride K., Smith E., Singh H., Glimcher L. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med 2002, 195:1003-1012.
10. Tominaga N., Ohkusu-Tsukada K., Udono H., Abe R., Matsuyama T., Yui K. Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4. Int Immunol 2003, 15:1-10.
11. Suzuki S., Honma K., Matsuyama T., et al. Critical roles of interferon regulatory factor 4 in CD11b high CD8alpha-dendritic cell development. Proc Natl Acad Sci USA 2004, 101:8981-8986.
12. Gilmour J., Lavender P. Control of IL-4 expression in T helper 1 and 2 cells. Immunology 2008, 124:437-444.
13. Mamane Y., Sharma S., Petropoulos L., Lin R., Hiscott J. Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52. Immunity 2000, 12:129-140.
14. Hu C.M., Jang S.Y., Fanzo J.C., Pernis A.B. Modulation of T cell cytokine production by interferon regulatory factor-4. J Biol Chem 2002, 277:49238-49246.
15. Ramos J.C., Ruiz P., Ratner L., et al. IRF-4 and c-Rel expression in antiviral resistant adult T-cell leukemia/lymphoma. Blood 2007, 109:3060-3068.
16. Puig O., Caspary F., Rigaut G., et al. The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods 2001, 24:218-229.
17. Brownell E., Mittereder N., Rice N.R. A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon. Oncogene 1989, 4:935-942.
18. Müller M.M., Schreiber E., Schaffner W., Matthias P. Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells. Nucleic Acids Res 1989, 17:6420.
19. Banerjee D., Liou H.C., Sen R. C-Rel-dependent priming of naive T cells by inflammatory cytokines. Immunity 2005, 23:445-458.
20. Honma K., Kimura D., Tominaga N., Miyakoda M., Matsuyama T., Yui K. Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. Proc Natl Acad Sci USA 2008, 105:15890-15895.
21. Honda K., Taniguchi T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunology 2006, 6:644-658.
22. Chen Q., Yang W., Gupta S., et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 2008, 29:899-911.
23. Negishi H., Ohba Y., Yanai H., et al. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci USA 2005, 102:15989-15994.
24. Imaizumi Y., Kohno T., Yamada Y., et al. Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia. Jpn J Cancer Res 2001, 92:1284-1292.
25. Schroder K., Hertzog P.J., Ravasi T., Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004, 75:163-189.
26. Li-Weber M., Krammer P.H. Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 2003, 3:534-543.
27. Grumont R.J., Gerondakis S. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB. J Exp Med 2000, 191:1281-1292.
28. Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 2005, 5:472-484.
29. Kim H.P., Imbert J., Leonard W.J. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev 2006, 17:349-366.
30. Isomura I., Palmer S., Grumont R.J., et al. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med 2009, 206:3001-3014.
31. Zheng Y., Chaudhry A., Kas A., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 458:351-356.
32. Kim P.S., Ahmed R. Features of responding T cells in cancer and chronic infection. Curr Opin Immunol 2010, 22:223-230.