Efficacy and safety of a new 450 mg/ml florfenicol formulation administered intramuscularly in the treatment of bacterial bovine respiratory disease

Veterinary Record

Volumn 169, Issue 20, 2011, Pages 526-

  Thiry, J ^a   Rubion, S ^a   Sarasola, P ^b   Bonnier, M ^c   Hartmann, M ^d   De Haas, V ^a  

^a MERCK ANIMAL HEALTH   (United States)

^b Ondax Scientific ^*  (Spain)

^c Institut Santé et Agro Environnement   (France)

^d Intervet Innovation GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG DERIVATIVE; FLORFENICOL; THIAMPHENICOL;

ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CATTLE DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; EPIDEMIC; INTRAMUSCULAR DRUG ADMINISTRATION; MICROBIOLOGY; MYCOPLASMOSIS; NEWBORN; PASTEURELLOSIS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; CATTLE; CATTLE DISEASES; DISEASE OUTBREAKS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAMUSCULAR; MYCOPLASMA INFECTIONS; PASTEURELLA INFECTIONS; RESPIRATORY TRACT INFECTIONS; THIAMPHENICOL; TREATMENT OUTCOME;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE; HISTOPHILUS SOMNI; MANNHEIMIA HAEMOLYTICA; MYCOPLASMA BOVIS; PASTEURELLA MULTOCIDA;

EID: 81455136027     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.d5498     Document Type: Article

References (34)

1. ADAMS, P. E., VARMA, K. J., POWERS, T. E. & LAMENDOLA, J. F. (1937) Tissue concentrations and pharmacokinetics of florfenicol in male veal calves given repeated doses. American Journal of Veterinary Research 48, 1725-1732
2. ASSIE, S., BAREILLE, N., BEAUDEAU, F. & SEEGERS, H. (2009) Management- and housing-related risk factors of respiratory disorders in non-weaned French Charolais calves. Preventive Veterinary Medicine 91, 218-225
3. BARRETT, D. C. (2000) Cost-effective antimicrobial drug selection for the management and control of respiratory disease in European cattle. Veterinary Record 146, 545-550 (Pubitemid 30248849)
4. BOOKER, C. W., JIM, G. K., GUICHON, P. T., SCHUNICHT, O. C., THORLAKSON, B. E. & LOCKWOOD, P. W. (1997) Evaluation of florfenicol for the treatment of undifferentiated fever in feedlot calves in western Canada. Canadian Veterinary Journal 38, 555-560 (Pubitemid 127510756)
5. CATRY, B., DUCHATEAU, L., VAN DE VEN, J., LAEVENS, H., OPSOMER, G., HAESEBROUCK, F. & DE KRUIF, A. (2003) Efficacy of metaphylactic florfenicol therapy during natural outbreaks of bovine respiratory disease. Journal of Veterinary Pharmacology and Therapeutics 31, 479-487
6. DE HAAS, V., LOCKWOOD, P. W, KATZ, T. & VARMA, K. J. (1994) Efficacy of florfenicol in the treatment of bovine respiratory disease: results of the European clinical trials. Proceedings of the International Symposium on Bovine Respiratory Disease: New Therapeutic Advances. XVIII World Buiatrics Congress. Bologna, August 29 to September 2, 1994. pp 37-44
7. DE HAAS, V., BONNIER, M., GICGUEL, M., ETORÉ, F & SHUSTER, D. (2002) Florfenicol: A time-or concentration dependent antibiotic? Proceedings of the International Symposium on New Advances in Calf Disease Management. XXII world Buiatrics Congress. Hannover, August 18 to 23, 2002. pp 17-25
8. DE IHAAS, V., ETORE, F., BONNIER, M., CALVO, E., MIOTTO, L., CLOET, P. R., MORRIS, F., MONTGOMERY, A., FRANZ, N. & VAN DE VEN, J. (2006) The incidence and sensitivity of the major bovine respiratory disease pathogens in Europe. Proceedings of the International Symposium on Bovine Respiratory Disease Complex, Setting a new therapeutic standard: a multimodal approach. XXIV world Buiatrics Congress. Nice, October 15 to 19, 2006. pp 33-39
9. EMEA/CVMP (2000) VICH Topic GL9: Guideline on Good Clinical Practices. www.ema.europa.eu/docs/en-GB/document-library/Scientific-guideline/2009/10/ WC500004343.pdf. Accessed April 01, 2011
10. FULTON, R. W., BLOOD, K. S., PANCIERA, R. J., PAYTON, M. E., RIDPATH, J. F., CONFER, A. W., SALIKI, J. T., BURGE, L. T., WELSH, R D., JOHNSON, B. J. & RECK, A. (2009) Lung pathology and infectious agents in fatal feedlot pneumonias and relationship with mortality, disease onset, and treatments. Journal of Veterinary Diagnostic Investigation 21, 464-477
11. GONZALEZ-MARTIN, J. V, ELVIRA, L., CERVINO LOPEZ, M., PÉREZ VILLALOBOS, N., CALVO LOPEZ-GUERRERO, E. & ASTIZ, S. (2011) Reducing antibiotic use: selective metaphylaxis with florfenicol in commercial feedlots. Livestock Science In press, doi:10.1016/j.livsci.2011.05.016
12. GOURLAY, R. N. & HOUGHTON, S. B. (1935) Experimental pneumonia in conventionally reared and gnotobiotic calves by dual infection with Mycoplasma bovis and Pasteurella haemolytica. Research in Veterinary Science 38, 377-382
13. HANNAN, P. C. (2000) Guidelines and recommendations for antimicrobial minimum inhibitory concentration (MIC) testing against veterinary Mycoplasma species. International Research Programme on Comparative Mycoplasmology Veterinary Research 31, 373-395 (Pubitemid 30621974)
14. JIM, G. K., BOOKER, C. W, GUICHON, P. T, SCHUNICHT, O. C., WILDMAN, B. K., JOHNSON, J. C. & LOCKWOOD, P. W. (1999) A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada. Canadian Veterinary Journal 40, 179-184 (Pubitemid 29169117)
15. KEHRENBERG, C. & SCHWARZ, S. (2005) Plasmid-borne florfenicol resistance in Pasteurella multocida. Journal of Antimicrobial Chemotherapy 55, 773-775 (Pubitemid 40691860)
16. KEHRENBERG, C., WALLMANN, J. & SCHWARZ, S. (2003) Molecular analysis of florfenicol-resistant Pasteurella multocida isolates in Germany. Journal of Antimicrobial Chemotherapy 62, 951-955
17. LEKEUX, P. & COGHE, J. (2004) Affections respiratoires bovines: évolution des lésions pulmonaires et rapidité d'intervention. Proceedings Congrès de la Société Française de Buiatrie. Paris, November 23 to 24, 2004. pp 39-94
18. LOBELL, R. D., VARMA, K. J., JOHNSON, J. C., SAMS, R A., GERKEN, D. F. & ASHCRAFT, S. M. (1994) Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle. Journal of Veterinary Pharmacology and Therapeutics 17, 253-253
19. MAKOSCHEY, B., LEKEUX, P., LACROUX, C., TAYLOR, G., HODGSON, C., LETELLIER, C. & OTHERS (2008) Concepts in the prevention of bovine respiratory disease. Berliner und Munchener Tierarztliche Wochenschrift 121, 446-449
20. MAUNSELL, F. P., WOOLUMS, A. R., FRANCOZ, D., ROSENBUSCH, R F., STEP, D. L., WILSON, D. J. & JANZEN, E. D. (2011) Mycoplasma bovis Infections in Cattle. Journal of Veterinary Internal Medicine 25, 772-783
21. NEU, H. C. & FU, K. P. (1980) In vitro activity of chloramphenicol and thiamphenicol analogs. Antimicrobial Agents Chemotherapy 18, 311-316 (Pubitemid 11231250)
22. NICHOLAS, R. A. (2011) Bovine mycoplasmosis: silent and deadly. Veterinary Record 168, 459-462
23. NICHOLAS, R. A. & AYLING, R. D. (2003) Mycoplasma bovis: disease, diagnosis, and control. Research in Veterinary Science 74, 105-112 (Pubitemid 36395592)
24. SCHWARZ, S. & CHASLUS-DANCLA, E. (2001) Use of antimicrobials in veterinary medicine and mechanisms of resistance. Veterinary Research 32, 201-225 (Pubitemid 32595206)
25. SOEHNLEN, M. K., KUNZE, M. E., KARUNATHILAKE, K. E., HENWOOD, B. M., KARIYAWASAM, S., WOLFGANG, D. R. & JAYARAO, B. M. (2011) In vitro antimicrobial inhibition of Mycoplasma bovis isolates submitted to the Pennsylvania Animal Diagnostic Laboratory using flow cytometry and a broth microdilution method. Journal of Veterinary Diagnostic Investigation 23, 547-551
26. SYRIOPOULOU, V P., HARDING, A. L., GOLDMANN, D. A. & SMITH, A. L. (1981) In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Antimicrobial Agents Chemotherapy 19, 294-297 (Pubitemid 11157514)
27. TAYLOR, J. D., FULTON, R W, LEHENBAUER, T. W, STEP, D. L. & CONFER, A. W. (2010) The epidemiology of bovine respiratory disease: what is the evidence for predisposing factors? Canadian Veterinary Journal 51, 1095-1102
28. THOMAS, A., BALL, H., DIZIER, I., TROLIN, A., BELL, C., MAINIL, J. & LINDEN, A. (2002) Isolation of Mycoplasma species from the lower respiratory tract of healthy cattle and cattle with respiratory disease in Belgium. Veterinary Record 151, 472-476 (Pubitemid 35238240)
29. THOMAS, A, MAINIL, J. & LINDEN, A. (2003) Mycoplasma bovis: synthèse des connaissances actuelles. Annales de Médecine Vétérinaire 147, 23-39 (Pubitemid 37100939)
30. VARMA, K. J. (1994) Microbiology, pharmacokinetic disposition and safety of florfenicol in cattle. Proceedings of the International Symposium on Bovine Respiratory Disease: New Therapeutic Advances. XVIII World Buiatrics Congress. Bologna, August 29 to September 2, 1994. pp 13-24
31. VARMA, K. J., ADAMS, P. E., POWERS, T E., POWERS, J. D. & LAMENDOLA, J. F. (1986) Pharmacokinetics of florfenicol in veal calves. Journal of Veterinary Pharmacology and Therapeutics 9, 412-425
32. VARMA, K. J., LOCKWOOD, P. W, COSGROVE, S. B. & ROGERS, E. R. (1993) Pharmacology, safety, and clinical efficacy of Nuflor® (florfenicol) following subcutaneous administration to cattle. Proceedings of the XX World Buiatrics Congress. Sidney, July 6 to 10, 1993. pp 511
33. WATTS, J. L. & SWEENEY, M. T. (2010) Antimicrobial resistance in bovine respiratory disease pathogens: measures, trends, and impact on efficacy. Veterinary Clinics of North America: Pood Animal Practice 26, 79-88
34. WATTS, J. L, SHRYOCK, T R, APLEY, M., BADE, D. J., BROWN, S. D., GRAY, J. T. & OTHERS (2008) Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard-third edition. Clinical and Laboratory Standards Institute 28, 1-99