Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 5, 2011, Pages 1152-1163

  Darlington, Daniel N ^a   Delgado, Angel V ^a   Kheirabadi, Bijan S ^a   Fedyk, Chriselda G ^a   Scherer, Michael R ^a   Pusateri, Anthony E ^a   Wade, Charles E ^a   Cap, Andrew P ^a   Holcomb, John B ^a   Dubick, Michael A ^a  

^a US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

APTT; Coagulopathy; Hemodilution; Hemorrhage; Hemostasis; PT; TEG

Indexed keywords

ALBUMIN; FIBRINOGEN; HEMOGLOBIN; HETASTARCH; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RINGER LACTATE SOLUTION; SODIUM CHLORIDE;

ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING PARAMETERS; BLOOD COMPONENT THERAPY; BLOOD SAMPLING; DRUG EFFICACY; HEMODILUTION; HEMOPHILIA; HUMAN; IN VITRO STUDY; NORMAL HUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; THROMBOCYTE;

ALBUMINS; ANALYSIS OF VARIANCE; BLOOD COAGULATION TESTS; FACTOR VIIA; HEMODILUTION; HETASTARCH; HUMANS; ISOTONIC SOLUTIONS; PARTIAL THROMBOPLASTIN TIME; PLASMA SUBSTITUTES; PROTHROMBIN TIME; RECOMBINANT PROTEINS; REGRESSION ANALYSIS; SODIUM CHLORIDE; STATISTICS, NONPARAMETRIC; THROMBELASTOGRAPHY;

EID: 81455135457     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318215178c     Document Type: Article

References (59)

1. Holcomb JB, McMullin NR, Pearse L, et al. Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Ann Surg. 2007;245:986-991. (Pubitemid 46809302)
2. Kelly JF, Ritenour AE, McLaughlin DF, et al. Injury severity and causes of death from operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. J Trauma. 2008;64:S21-S26; discussion S26-S27.
3. Dutton RP, Stansbury LG, Leone S, Kramer E, Hess JR, Scalea TM. Trauma mortality in mature trauma systems: are we doing better? An analysis of trauma mortality patterns, 1997-2008. J Trauma. 2010;69: 620-626.
4. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65:748-754.
5. Schreiber MA. Coagulopathy in the trauma patient. Curr Opin Crit Care. 2005;11:590-597. (Pubitemid 41697333)
6. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13: 680-685. (Pubitemid 350059533)
7. Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy: its pathophysiology and treatment in the injured patient. World J Surg. 2007;31: 1055-1064. (Pubitemid 46716770)
8. American College of Surgeons. Advanced Trauma Life Support for Doctors ATLS: Manuals for Coordinators and Faculty. Chicago, IL: American College of Surgeons; 2008.
9. Santry HP, Alam HB. Fluid resuscitation: past, present, and the future. Shock. 2010;33:229-241.
10. National Association of Emergency Medical Technicians (U.S.). Pre-Hospital Trauma Life Support Committee, American College of Surgeons. Committee on Trauma. PHTLS: Prehospital Trauma Life Support. St. Louis, MO: Mosby JEMS/Elsevier; 2007.
11. Gutierrez G, Reines HD, Wulf-Gutierrez ME. Clinical review: hemorrhagic shock. Crit Care. 2004;8:373-381. (Pubitemid 39468060)
12. Croom KF, McCormack PL. Recombinant factor VIIa (eptacog alfa): a review of its use in congenital hemophilia with inhibitors, acquired hemophilia, and other congenital bleeding disorders. BioDrugs. 2008; 22:121-136. (Pubitemid 351414753)
13. Mackman N. Tissue-specific hemostasis: role of tissue factor. J Thromb Haemost. 2008;6:303-305.
14. Mackman N. The role of tissue factor and factor VIIa in hemostasis. Anesth Analg. 2009;108:1447-1452.
15. Malý MA, Tomasov P, Hájek P, et al. The role of tissue factor in thrombosis and hemostasis. Physiol Res. 2007;56:685-695.
16. Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation. Anesth Analg. 2009;108:1433-1446.
17. Alam HB, Rhee P. New developments in fluid resuscitation. Surg Clin North Am. 2007;87:55-72, vi.
18. Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62:112-119. (Pubitemid 46102840)
19. Spinella PC, Perkins JG, McLaughlin DF, et al. The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion. J Trauma. 2008;64:286-293; discussion 293-284. (Pubitemid 351640428)
20. Allen GA, Hoffman M, Roberts HR, Monroe DM III. Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage. Can J Anaesth. 2002;49:S7-S14. (Pubitemid 36231118)
21. Hemker HC, Al Dieri R, Beguin S. Thrombin generation assays: accruing clinical relevance. Curr Opin Hematol. 2004;11:170-175. (Pubitemid 38952005)
22. Jamnicki M, Zollinger A, Seifert B, Popovic D, Pasch T, Spahn DR. Compromised blood coagulation: an in vitro comparison of hydroxyethyl starch 130/0.4 and hydroxyethyl starch 200/0.5 using thrombelastography. Anesth Analg. 1998;87:989-993. (Pubitemid 28501146)
23. Kheirabadi BS, Crissey JM, Deguzman R, et al. Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopathy and increasing hemorrhage in rabbits. J Trauma. 2008;64:1218 -1228; discussion 1228-1219. (Pubitemid 351671216)
24. Nielsen VG, Baird MS. Extreme hemodilution in rabbits: an in vitro and in vivo Thrombelastographic analysis. Anesth Analg. 2000;90:541-545. (Pubitemid 30117508)
25. Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O. The in vitro effects of crystalloids and colloids on coagulation. Anaesthesia. 2002;57:1102-1108. (Pubitemid 35282559)
26. McCammon AT, Wright JP, Figueroa M, Nielsen VG. Hemodilution with albumin, but not Hextend, results in hypercoagulability as assessed by Thrombelastography in rabbits: role of heparin-dependent serpins and factor VIII complex. Anesth Analg. 2002;95:844-850; table of contents.
27. Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340: 409-417. (Pubitemid 29084771)
28. Blajchman MA, Slichter SJ, Heddle NM, Murphy MF. New strategies for the optimal use of platelet transfusions. Hematology Am Soc Hematol Educ Program. 2008:198-204.
29. Spahn DR. Strategies for transfusion therapy. Best Pract Res. 2004;18: 661-673. (Pubitemid 39145051)
30. Spinella PC, Holcomb JB. Resuscitation and transfusion principles for traumatic hemorrhagic shock. Blood Rev. 2009;23:231-240.
31. AABB. Technical Manual. Bethesda, MD: AABB; 2008.
32. AABB. Transfusion Therapy: Clinical Principles and Practice. Bethesda, MD: AABB; 2011.
33. Weiss L, Elkin G. Effects of mechanical trauma and free-radical exposure on the membrane-integrity of Ehrlich ascites tumor cells. Biorheology. 1993;30:43-48. (Pubitemid 23181140)
34. Thyes C, Madjdpour C, Frascarolo P, et al. Effect of high- and low-molecular-weight low-substituted hydroxyethyl starch on blood coagulation during acute normovolemic hemodilution in pigs. Anesthesiology. 2006;105:1228-1237. (Pubitemid 44808587)
35. Viuff D, Lauritzen B, Pusateri AE, Andersen S, Rojkjaer R, Johansson PI. Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven). Br J Anaesth. 2008;101:324-331.
36. Bladbjerg EM, Jespersen J. Activity of recombinant factor VIIa under different conditions in vitro: effect of temperature, pH, and haemodilution. Blood Coagul Fibrinolysis. 2008;19:369-374.
37. Fenger-Eriksen C, Tønnesen E, Ingerslev J, Sørensen B. Mechanisms of hydroxyethyl starch-induced dilutional coagulopathy. J Thromb Haemost. 2009;7:1099-1105.
38. Ganter MT, Schmuck S, Hamiel CR, et al. Monitoring recombinant factor VIIa treatment: efficacy depends on high levels of fibrinogen in a model of severe dilutional coagulopathy. J Cardiothorac Vasc Anesth. 2008;22:675-680.
39. Lauritzen B, Viuff D, Tranholm MP, Ezban M. rFVIIa and NN1731 reduce bleeding in hydroxyethyl starch hemodiluted rabbits. J Trauma. 2010;69:1196-1202.
40. Boldt J. Modern rapidly degradable hydroxyethyl starches: current concepts. Anesth Analg. 2009;108:1574-1582.
41. Kozek-Langenecker SA. Effects of hydroxyethyl starch solutions on hemostasis. Anesthesiology. 2005;103:654-660. (Pubitemid 41243429)
42. Dickneite G, Dörr B, Kaspereit F, Tanaka KA. Prothrombin complex concentrate versus recombinant factor VIIa for reversal of hemodilutional coagulopathy in a porcine trauma model. J Trauma. 2010;68: 1151-1157.
43. Schols SE, Feijge MA, Lancé MD, et al. Effects of plasma dilution on tissue-factor-induced thrombin generation and thromboelastography: partly compensating role of platelets. Transfusion. 2008;48:2384-2394.
44. Hardy JF, de Moerloose P, Samama CM; Members of the Groupe d'Intérêt en Hémostase Périopératoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth. 2006;53:S40-S58. (Pubitemid 44150884)
45. Perkins JG, Cap AP, Weiss BM, Reid TJ, Bolan CD. Massive transfusion and nonsurgical hemostatic agents. Crit Care Med. 2008;36: S325-S339.
46. Zhu D. Mathematical modeling of blood coagulation cascade: kinetics of intrinsic and extrinsic pathways in normal and deficient conditions. Blood Coagul Fibrinolysis. 2007;18:637-646. (Pubitemid 47479414)
47. Svensen C, Hahn RG. Volume kinetics of Ringer solution, dextran 70, and hypertonic saline in male volunteers. Anesthesiology. 1997;87: 204-212. (Pubitemid 27435361)
48. Lodge JP, Jonas S, Oussoultzoglou E, et al. Recombinant coagulation factor VIIa in major liver resection: a randomized, placebo-controlled, double-blind clinical trial. Anesthesiology. 2005;102:269-275. (Pubitemid 40189073)
49. Friederich PW, Henny CP, Messelink EJ, et al. Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomized trial. Lancet. 2003;361:201-205. (Pubitemid 36126219)
50. Bosch J, Thabut D, Bendtsen F, et al; European Study Group on rFVIIa in UGI Haemorrhage. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial. Gastroenterology. 2004;127:1123-1130. (Pubitemid 39345881)
51. Perkins JG, Schreiber MA, Wade CE, Holcomb JB. Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion. J Trauma. 2007;62:1095-1099; discussion 1099-1101. (Pubitemid 46742957)
52. Boffard KD, Riou B, Warren B, et al; NovoSeven Trauma Study Group. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma. 2005;59:8-15; discussion 15-18.
53. Dutton RP, Hess JR, Scalea TM. Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patients. J Clin Anesth. 2003;15:184-188. (Pubitemid 36593444)
54. Korte WC, Moor S. Near fatal hemorrhage in traumatic bilateral leg amputation with coagulopathy, acidosis, and hypothermia and salvage therapy with recombinant factor VIIa. J Trauma. 2007;63:E1-E4. (Pubitemid 47057593)
55. Stein DM, Dutton RP, Hess JR, Scalea TM. Low-dose recombinant factor VIIa for trauma patients with coagulopathy. Injury. 2008;39: 1054-1061.
56. Wade CE, Dubick MA, Blackbourne LH, Holcomb JB. It is time to assess the utility of thrombelastography in the administration of blood products to the patient with traumatic injuries. J Trauma. 2009;66: 1258.
57. Hauser CJ, Boffard K, Dutton R, et al; CONTROL Study Group. Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010;69:489-500.
58. Allen GA, Hoffman M, Roberts HR, Monroe DM. Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia. Br J Haematol. 2006;134:314-319. (Pubitemid 43990793)
59. Monroe DM. Modeling the action of factor VIIa in dilutional coagulopathy. Thromb Res. 2008;122(suppl 1):S7-S10.