Flourescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors

Modern Pathology

Volumn 17, Issue 11, 2004, Pages 1309-1313

  Kernek, Kevin M ^a   Brunelli, Matteo ^a,b   Ulbright, Thomas M ^a   Eble, John N ^a   Martignoni, Guido ^b   Zhang, Shaobo ^a   Michael, Helen ^a   Cummings, Oscar W ^a   Cheng, Liang ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VERONA   (Italy)

^c INDIANA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chromosome 12p; Fluorescence in situ hybridization; Germ cell tumors; Metastatic tumors; Origin; Testis

Indexed keywords

ADENOCARCINOMA; ARTICLE; CHROMOSOME 12P; DIAGNOSTIC VALUE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GERM CELL; GERM CELL TUMOR; HISTOPATHOLOGY; HUMAN; METASTASIS; PRIORITY JOURNAL; SARCOMA; SOMATIC CELL GENETICS; TESTIS TUMOR; UNDIFFERENTIATED CARCINOMA; ADULT; CHROMOSOME 12; GENETICS; MALE; MEDIASTINUM TUMOR; MIDDLE AGED; MULTIPLE CANCER; NEOPLASM;

PARAFFIN;

ADENOCARCINOMA; ADULT; CHROMOSOMES, HUMAN, PAIR 12; GENE AMPLIFICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEDIASTINAL NEOPLASMS; MIDDLE AGED; NEOPLASMS, GERM CELL AND EMBRYONAL; NEOPLASMS, MULTIPLE PRIMARY; PARAFFIN EMBEDDING; SARCOMA; TESTICULAR NEOPLASMS;

EID: 8144226611     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800195     Document Type: Article

References (17)

1. Jemal A, Tiwari RC, Murry T, et al. Cancer statistics, 2004. CA Cancer J Clin 2004;54:8-29.
2. Kernek KM, Ulbright TM, Zhang S, et al. Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis. Am J Pathol 2003;163:2477-2484.
3. Brunelli M, Eble JN, Zhang S, et al. Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y which are typical of papillary renal cell carcinoma and papillary adenoma. Mod Pathol 2003; 16:1060-1063.
4. Brunelli M, Eble IN, Martignoni G, et al. Gain of chromosomes 7, 17, 12, 16, and 20, and loss of Y occur early in the evolution of papillary renal cell neoplasia: a fluorescent in situ hybridization study. Mod Pathol 2003;16:1053-1059.
5. Latta EK, Tjan S, Parkes RK, et al. The role of HER2/neu overexpression/amplification in the progression of ductal carcinoma in situ to invasive carcinoma of the breast. Mod Pathol 2002;15:1318-1325.
6. Looijenga LHJ, Oosterhuis JW. Pathogenesis of testicular germ cell tumours. Rev Reprod 1999;4:90-100.
7. Pienkowska-Grela B, Grygalewicz B, Bregula U. Over-representation of the short arm of chromosome 12 in seminoma and nonseminoma groups of testicular germ cell tumors. Cancer Genet Cytogenet 2002;134:102-108.
8. Samaniego F, Rodriguez E, Houldsworth J, et al. Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification. Genes Chromosomes Cancer 1990;1:289-300.
9. Rodriguez E, Houldsworth J, Reuter VE, et al. Molecular cytogenetic analysis of i(12p)-negative human male germ cell tumors. Genes Chromosomes Cancer 1993;8:230-236.
10. Suijkerbuijk RF, Sinke RJ, Weghuis DE, et al. Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression? Cancer Genet Cytogenet 1994;78:145-152.
11. Chaganti RSK, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res 2000;60:1475-1482.
12. Geurts van Kessel A, Suijkerbuijk RF, Sinke RJ, et al. Molecular cytogenetics of human germ cell tumours: i(12p) and related chromosomal anomalies. Eur Urol 1993;23:23-29.
13. Smolarek TA, Blough RI, Foster RS, et al. Identification of multiple chromosome 12 abnormalities in human testicular germ cell tumors by two-color fluorescence in situ hybridization (FISH). Genes Chromosomes Cancer 1995;14:252-258.
14. Mostert MMC, van de Pol M, Olde Weghuis D, et al. Comparative genomic hybridization of germ cell tumors of the adult testis: confirmation of karyotypic findings and identification of a 12p-amplicon. Cancer Genet Cytogenet 1996;89:146-152.
15. Blough RI, Smolarek TA, Ulbright TM, et al. Bicolor fluorescence in situ hybridization on nuclei from formalin-fixed, paraffin-embedded testicular germ cell tumors: comparison with standard metaphase analysis. Cancer Genet Cytogenet 1997;94:79-84.
16. Motzer RJ, Rodriquez E, Reuter VE, et al. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Inst 1991;83:341-346.
17. Summersgill B, Goker H, Osin P, et al. Establishing germ cell origin of undifferentiated tumors by identifying gain of 12p material using comparative genomic hybridization analysis of paraffin-embedded samples. Diag Mol Pathol 1998;7:260-266.