메뉴 건너뛰기




Volumn 42, Issue 11, 2004, Pages 1056-1065

Enhancement of gastrointestinal absorption of poorly water soluble drugs via lipid based systems

Author keywords

Gastrointestinal absorption; Lipid based system; Poorly water soluble drugs

Indexed keywords

ABSORPTION; BIOLOGICAL ORGANS; DIGESTIVE SYSTEM; LIPIDS; PHYSIOLOGY; SOLUBILITY;

EID: 8144225703     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (18)

References (56)
  • 1
    • 0002683888 scopus 로고    scopus 로고
    • Combinatorial chemistry
    • Borman B, Combinatorial chemistry, Chem Eng News, 6 (1998) 47.
    • (1998) Chem Eng News , vol.6 , pp. 47
    • Borman, B.1
  • 2
    • 8144223569 scopus 로고    scopus 로고
    • Strategies for optimizing oral drug delivery
    • Lipinski C A, Strategies for optimizing oral drug delivery, Kobe, 4 (1999) 19.
    • (1999) Kobe , vol.4 , pp. 19
    • Lipinski, C.A.1
  • 3
    • 0035754867 scopus 로고    scopus 로고
    • Lipid based vehicle for oral drug delivery
    • Stuchlik M & Zak S, Lipid based vehicle for oral drug delivery, Biomed papers, 145 (2001) 17.
    • (2001) Biomed Papers , vol.145 , pp. 17
    • Stuchlik, M.1    Zak, S.2
  • 4
    • 0342617694 scopus 로고    scopus 로고
    • Lipid-based vehicles for the oral delivery of poorly water soluble drugs
    • Humberstone A J & Charman W N, Lipid-based vehicles for the oral delivery of poorly water soluble drugs, Adv Drug Deliv Rev, 25 (1997) 103.
    • (1997) Adv Drug Deliv Rev , vol.25 , pp. 103
    • Humberstone, A.J.1    Charman, W.N.2
  • 8
    • 0019461547 scopus 로고
    • Fat digestion in the newborn: Characterisation of lipase in gastric aspirates of premature and term infants
    • Hamosh M, Scanlon, Ganot D, Likel M, Scanlon K B & Hamosh P, Fat digestion in the newborn: Characterisation of lipase in gastric aspirates of premature and term infants, J Clin Invest, 67 (1981) 838.
    • (1981) J Clin Invest , vol.67 , pp. 838
    • Hamosh, M.1    Scanlon2    Ganot, D.3    Likel, M.4    Scanlon, K.B.5    Hamosh, P.6
  • 9
    • 0021357477 scopus 로고
    • Fat digestion by lingual lipase: Mechanism of lipolysis in the stomach and upper small intestine
    • Liao T H, Hamosh P & Hasmosh M, Fat digestion by lingual lipase: Mechanism of lipolysis in the stomach and upper small intestine, Pediatr Res, 18 (1984) 402.
    • (1984) Pediatr Res , vol.18 , pp. 402
    • Liao, T.H.1    Hamosh, P.2    Hasmosh, M.3
  • 10
    • 0002953749 scopus 로고
    • The structure and function of pancreatic enzymes
    • edited by L R Jhonson (Raven Press, New York)
    • Lowe M E, The structure and function of pancreatic enzymes, in Physiology of the gastrointestinal tract, edited by L R Jhonson (Raven Press, New York) 1994, 1531.
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1531
    • Lowe, M.E.1
  • 11
    • 0018886158 scopus 로고
    • Importance of phospolipids, pancreatic phospholipase A 2 and fatty acid for digestion of dietary fat
    • Borgstrom B, Importance of phospolipids, pancreatic phospholipase A 2 and fatty acid for digestion of dietary fat, Gastroenterology, 78(1980) 954.
    • (1980) Gastroenterology , vol.78 , pp. 954
    • Borgstrom, B.1
  • 12
    • 0024548560 scopus 로고
    • Fatty acids generated by gastric lipase promote human milk triacyglycerol digestion by pancreatic colipase-dependent lipase
    • Bernback S, Blackberg L & Hernell O, Fatty acids generated by gastric lipase promote human milk triacyglycerol digestion by pancreatic colipase-dependent lipase, Biochem Biophys Acta, 1001 (1989) 286.
    • (1989) Biochem Biophys Acta , vol.1001 , pp. 286
    • Bernback, S.1    Blackberg, L.2    Hernell, O.3
  • 13
    • 0019401139 scopus 로고
    • Bile bsalts and lipids in the aqueous intraluminal phase during the digestion of a standard meal in man
    • Rautureau M, Bisalli A & Rimbaud J C, Bile bsalts and lipids in the aqueous intraluminal phase during the digestion of a standard meal in man, Clin Biol, 5 (1981) 417.
    • (1981) Clin Biol , vol.5 , pp. 417
    • Rautureau, M.1    Bisalli, A.2    Rimbaud, J.C.3
  • 14
    • 0014875613 scopus 로고
    • The characteristics of mixed miceller solutions with particular reference to man
    • Cary M C & Small D M, The characteristics of mixed miceller solutions with particular reference to man, Am J Med, 49 (1970) 590.
    • (1970) Am J Med , vol.49 , pp. 590
    • Cary, M.C.1    Small, D.M.2
  • 15
    • 0015416424 scopus 로고
    • Micelle formation by bile salts
    • Cary M C & Small D M, Micelle formation by bile salts, Arch Intern Med, 130 (1972) 506.
    • (1972) Arch Intern Med , vol.130 , pp. 506
    • Cary, M.C.1    Small, D.M.2
  • 16
    • 0015174080 scopus 로고
    • Unstirred water layers and absorption across the intestinal mucosa
    • Dietschy J M, Sallee V L & Wilson F A, Unstirred water layers and absorption across the intestinal mucosa, Gastroenterology, 61 (1971) 932.
    • (1971) Gastroenterology , vol.61 , pp. 932
    • Dietschy, J.M.1    Sallee, V.L.2    Wilson, F.A.3
  • 17
    • 0015209610 scopus 로고
    • Unstirred water layers in intestine: Rate determinant of fatty acid from miceller solutions
    • Wilson F A, Sallee V L & Dietschy J M, Unstirred water layers in intestine: Rate determinant of fatty acid from miceller solutions, Science, 174 (1971) 1031.
    • (1971) Science , vol.174 , pp. 1031
    • Wilson, F.A.1    Sallee, V.L.2    Dietschy, J.M.3
  • 18
    • 0017121838 scopus 로고
    • The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the mucosal cell
    • Westergaard H & Dietschy J M, The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the mucosal cell, J Clin Invest, 58 (1976) 97.
    • (1976) J Clin Invest , vol.58 , pp. 97
    • Westergaard, H.1    Dietschy, J.M.2
  • 19
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • O 'Driscoll M C, Lipid-based formulations for intestinal lymphatic delivery, Eur J Pharm Sci, 15 (2002) 405.
    • (2002) Eur J Pharm Sci , vol.15 , pp. 405
    • O'Driscoll, M.C.1
  • 20
    • 0000483832 scopus 로고
    • The portal transport of absorbed fatty acids
    • Kiyasu J Y, Bloom B & Chaikoff I L, The portal transport of absorbed fatty acids, J Biol Chem, 199 (1952) 415.
    • (1952) J Biol Chem , vol.199 , pp. 415
    • Kiyasu, J.Y.1    Bloom, B.2    Chaikoff, I.L.3
  • 21
    • 0000409247 scopus 로고
    • Direct esterification of monoglycerides with palmityl coenzyme a by intestinal epithelial subcelluar fractions
    • Senior J R & Isselbacher K J, Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcelluar fractions, J Biol Chem, 237 (1962) 1454.
    • (1962) J Biol Chem , vol.237 , pp. 1454
    • Senior, J.R.1    Isselbacher, K.J.2
  • 22
    • 0013809384 scopus 로고
    • The composition and structure of lymph chylomicrons in dog, rat and man
    • Zilversmit D B, The composition and structure of lymph chylomicrons in dog, rat and man, J Clin Invest, 44 (1965) 1610.
    • (1965) J Clin Invest , vol.44 , pp. 1610
    • Zilversmit, D.B.1
  • 23
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • Constantinides P P, Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects, Pharm Res, 12 (1995) 1561.
    • (1995) Pharm Res , vol.12 , pp. 1561
    • Constantinides, P.P.1
  • 24
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • Gershanik T & Benita S, Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs, Eur J Pharm Bio-pharm, 50 (2000) 179.
    • (2000) Eur J Pharm Bio-pharm , vol.50 , pp. 179
    • Gershanik, T.1    Benita, S.2
  • 25
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • Pouton C W, Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems, Eur J Pharm Sci, 11 (2000) S93.
    • (2000) Eur J Pharm Sci , vol.11
    • Pouton, C.W.1
  • 26
    • 0028063546 scopus 로고
    • The pharmacokinetics of sandimmune neoral: A new oral formulation of cyclosporin
    • Holt D W, Mueller E A, Kovarik J M, Van Breen J B & Kutz K, The pharmacokinetics of sandimmune neoral: A new oral formulation of cyclosporin, Transplant Proc, 26 (1994) 2935.
    • (1994) Transplant Proc , vol.26 , pp. 2935
    • Holt, D.W.1    Mueller, E.A.2    Kovarik, J.M.3    Van Breen, J.B.4    Kutz, K.5
  • 27
    • 0002304799 scopus 로고    scopus 로고
    • So you want to use lipid-based formulations in development
    • Roman R, So you want to use lipid-based formulations in development, Bull Tech Gattefosse, 92 (1999) 51.
    • (1999) Bull Tech Gattefosse , vol.92 , pp. 51
    • Roman, R.1
  • 28
    • 0036913716 scopus 로고    scopus 로고
    • Lipid-based systems for oral drug delivery: Enhancing the bioavailability of poorly water soluble drugs
    • Hauss J D, Lipid-based systems for oral drug delivery: Enhancing the bioavailability of poorly water soluble drugs, Am Pharm Rev, 4 (2002) 43.
    • (2002) Am Pharm Rev , vol.4 , pp. 43
    • Hauss, J.D.1
  • 29
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon G L, Lennernas H, Shah V P & Crison J R, A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res, 12 (1995) 413.
    • (1995) Pharm Res , vol.12 , pp. 413
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 30
    • 0027473738 scopus 로고
    • Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model
    • Oh D M, Curl R L & Amidon G L, Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model, Pharm Res, 10 (1993) 264.
    • (1993) Pharm Res , vol.10 , pp. 264
    • Oh, D.M.1    Curl, R.L.2    Amidon, G.L.3
  • 31
    • 0031913402 scopus 로고    scopus 로고
    • Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms
    • Dressman J B, Amidon G L, Reppas C & Shah V P, Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms, Pharm Res, 15 (1998) 11.
    • (1998) Pharm Res , vol.15 , pp. 11
    • Dressman, J.B.1    Amidon, G.L.2    Reppas, C.3    Shah, V.P.4
  • 33
    • 0023276505 scopus 로고
    • Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules
    • Charman W N & Stella V J, Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules, Int J Pharm, 34 (1986) 175.
    • (1986) Int J Pharm , vol.34 , pp. 175
    • Charman, W.N.1    Stella, V.J.2
  • 34
    • 0026593458 scopus 로고
    • Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: Comparison to DDT and hexachlorobenzene
    • Myers R A & Stella V J, Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: Comparison to DDT and hexachlorobenzene, Int J Pharm, 80 (1992) 511.
    • (1992) Int J Pharm , vol.80 , pp. 511
    • Myers, R.A.1    Stella, V.J.2
  • 35
    • 0027293527 scopus 로고
    • Deacylation-reacylation cycle: A possible absorption mechanism for the novel lymphotropic antitumor agent dipalmitoyl-phosphatidylfluorouridine in rats
    • Sakai A, Mori N, Shuto S & Suzuki T, Deacylation-reacylation cycle: A possible absorption mechanism for the novel lymphotropic antitumor agent dipalmitoyl-phosphatidylfluorouridine in rats, J Pharm Sci, 82 (1993) 575.
    • (1993) J Pharm Sci , vol.82 , pp. 575
    • Sakai, A.1    Mori, N.2    Shuto, S.3    Suzuki, T.4
  • 36
    • 0343408485 scopus 로고    scopus 로고
    • Lipophilic prodrugs designed for intestinal lymphatic transport
    • Charman W N & Porter C J H, Lipophilic prodrugs designed for intestinal lymphatic transport, Adv Drug Deliv Rev, 19 (1996) 149.
    • (1996) Adv Drug Deliv Rev , vol.19 , pp. 149
    • Charman, W.N.1    Porter, C.J.H.2
  • 37
    • 0026571249 scopus 로고
    • Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanism and potential toxicity
    • Swenson E C & Curatolo W J, Intestinal permeability enhancement for proteins, peptides and other polar drugs: Mechanism and potential toxicity, Adv Drug Deliv Rev, 8 (1992) 39.
    • (1992) Adv Drug Deliv Rev , vol.8 , pp. 39
    • Swenson, E.C.1    Curatolo, W.J.2
  • 41
    • 0033198334 scopus 로고    scopus 로고
    • Mixed micelles of sodium deoxycholate and polyoxyethylene sorbitan monooleate (Tween 80)
    • Haque M E, Das A R & Moulik S P, Mixed micelles of sodium deoxycholate and polyoxyethylene sorbitan monooleate (Tween 80), J Colloid Interface Sci, 217 (1999) 1.
    • (1999) J Colloid Interface Sci , vol.217 , pp. 1
    • Haque, M.E.1    Das, A.R.2    Moulik, S.P.3
  • 42
    • 0008890930 scopus 로고    scopus 로고
    • The structure and composition of ethyl hexadecanoate layers spread on aqueous solutions of hexaethylene glycol monododecyl ether
    • Lu J R, Su T J, Lawrence M J, Barlow D J, Warisnoicharoen W & Zuberi T, The structure and composition of ethyl hexadecanoate layers spread on aqueous solutions of hexaethylene glycol monododecyl ether, J Phys Chem B, 103 (1999) 4638.
    • (1999) J Phys Chem B , vol.103 , pp. 4638
    • Lu, J.R.1    Su, T.J.2    Lawrence, M.J.3    Barlow, D.J.4    Warisnoicharoen, W.5    Zuberi, T.6
  • 44
    • 0031780652 scopus 로고    scopus 로고
    • Interaction of a self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge
    • Gershanik T, Benzeno S & Benita S, Interaction of a self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge, Pharm Res, 15 (1998) 863.
    • (1998) Pharm Res , vol.15 , pp. 863
    • Gershanik, T.1    Benzeno, S.2    Benita, S.3
  • 45
    • 0035966510 scopus 로고    scopus 로고
    • Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery
    • Kim C K, Cho Y J & Gao Z G, Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery, J Control Release, 70 (2001) 149.
    • (2001) J Control Release , vol.70 , pp. 149
    • Kim, C.K.1    Cho, Y.J.2    Gao, Z.G.3
  • 46
    • 1842609789 scopus 로고    scopus 로고
    • Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of simvastatin in beagle dogs
    • Kang B K, Lee S J, Chon K S, Jeong Y S, Yuk H S, Khang G, Lee B H & Cho H S, Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of simvastatin in beagle dogs, Int J Pharm, 274(2004) 65.
    • (2004) Int J Pharm , vol.274 , pp. 65
    • Kang, B.K.1    Lee, S.J.2    Chon, K.S.3    Jeong, Y.S.4    Yuk, H.S.5    Khang, G.6    Lee, B.H.7    Cho, H.S.8
  • 47
    • 0025195880 scopus 로고
    • Coenzyme Q10: A new drug for cardiovascular disease
    • Greenberg S & Fishman W H, Coenzyme Q10: A new drug for cardiovascular disease, J Clin Pharmacol, 30 (1990) 590.
    • (1990) J Clin Pharmacol , vol.30 , pp. 590
    • Greenberg, S.1    Fishman, W.H.2
  • 48
    • 0035895309 scopus 로고    scopus 로고
    • Self emulsifying drug delivery systems (SEDDS) of coenzyme Q: 10 formulation development and bioavailability assessment
    • Kommuru T R, Gurley B, Khan M A & Reddy I K, Self emulsifying drug delivery systems (SEDDS) of coenzyme Q: 10 formulation development and bioavailability assessment, Int J Pharm, 212 (2001) 133.
    • (2001) Int J Pharm , vol.212 , pp. 133
    • Kommuru, T.R.1    Gurley, B.2    Khan, M.A.3    Reddy, I.K.4
  • 50
    • 0033093665 scopus 로고    scopus 로고
    • Practical implications of cyclooxygenase-2-specific inhibitors in orthopedics
    • Marshall K W, Practical implications of cyclooxygenase-2-specific inhibitors in orthopedics. Am J Orthop, 28 (1999) 19.
    • (1999) Am J Orthop , vol.28 , pp. 19
    • Marshall, K.W.1
  • 53
    • 8144229517 scopus 로고    scopus 로고
    • Polymorphic crystalline forms of celecoxib, WO 01/42222 A1, 2001
    • Leonard F, Patricia M, Polymorphic crystalline forms of celecoxib, WO 01/42222 A1, 2001.
    • Leonard, F.1    Patricia, M.2
  • 54
    • 21644461482 scopus 로고    scopus 로고
    • Formulation design of self-microemulsifying drug delivery systems for improved oral bioavilability of celecoxib
    • Accepted
    • Subramanian N, Ray S, Ghosal S K, Bhadra R & Moulik S P, Formulation design of self-microemulsifying drug delivery systems for improved oral bioavilability of celecoxib, Biol Pharm Bull (accepted).
    • Biol Pharm Bull
    • Subramanian, N.1    Ray, S.2    Ghosal, S.K.3    Bhadra, R.4    Moulik, S.P.5
  • 55
    • 0031914282 scopus 로고    scopus 로고
    • Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    • Haus D J, Fogal S E, Ficorilli J V, Price C A, Roy T, Jayara A A & Keirns J J, Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor, J Pharm Sci, 87 (1998) 164.
    • (1998) J Pharm Sci , vol.87 , pp. 164
    • Haus, D.J.1    Fogal, S.E.2    Ficorilli, J.V.3    Price, C.A.4    Roy, T.5    Jayara, A.A.6    Keirns, J.J.7
  • 56
    • 0034762181 scopus 로고    scopus 로고
    • A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine
    • Khoo S M, Edwards G A, Porter C J H & Charman W N, A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine, J Pharm Sci, 90 (2001) 1599.
    • (2001) J Pharm Sci , vol.90 , pp. 1599
    • Khoo, S.M.1    Edwards, G.A.2    Porter, C.J.H.3    Charman, W.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.