메뉴 건너뛰기




Volumn 5, Issue , 2011, Pages

Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; NEUROPILIN 2; NEUTRALIZING ANTIBODY; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 81355160889     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-5-193     Document Type: Article
Times cited : (53)

References (60)
  • 1
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • 10.1038/nature04478, 16355210
    • Carmeliet P. Angiogenesis in life, disease and medicine. Nature 2005, 438:932-936. 10.1038/nature04478, 16355210.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 3
    • 77951498400 scopus 로고    scopus 로고
    • Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications
    • Sung H-K, Michael IP, Nagy A. Multifaceted role of vascular endothelial growth factor signaling in adult tissue physiology: an emerging concept with clinical implications. Curr Opin Hematol 2010, 17:206-212.
    • (2010) Curr Opin Hematol , vol.17 , pp. 206-212
    • Sung, H.-.K.1    Michael, I.P.2    Nagy, A.3
  • 4
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • 10.1038/nature10144, 21593862
    • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011, 473:298-307. 10.1038/nature10144, 21593862.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 5
    • 34948896998 scopus 로고    scopus 로고
    • Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer
    • 10.1038/sj.bjc.6603923, 2360423, 17912242
    • Kut C, Mac Gabhann F, Popel AS. Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer. Br J Cancer 2007, 97:978-985. 10.1038/sj.bjc.6603923, 2360423, 17912242.
    • (2007) Br J Cancer , vol.97 , pp. 978-985
    • Kut, C.1    Mac Gabhann, F.2    Popel, A.S.3
  • 6
    • 79957553592 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker
    • 10.1371/journal.pone.0019873, 3102663, 21637343
    • Niers TM, Richel DJ, Meijers JC, Schlingermann RO. Vascular endothelial growth factor in the circulation in cancer patients may not be a relevant biomarker. PLoS ONE 2011, 6:e19873. 10.1371/journal.pone.0019873, 3102663, 21637343.
    • (2011) PLoS ONE , vol.6
    • Niers, T.M.1    Richel, D.J.2    Meijers, J.C.3    Schlingermann, R.O.4
  • 7
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • 10.1038/nrd3455, 21629292
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011, 10:417-427. 10.1038/nrd3455, 21629292.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 8
    • 79955042526 scopus 로고    scopus 로고
    • Vasculogenesis, angiogenesis and special features of tumor blood vessels
    • 10.2741/3796, 21196239
    • Hiratsuka S. Vasculogenesis, angiogenesis and special features of tumor blood vessels. Front Biosci 2011, 16:1413-1427. 10.2741/3796, 21196239.
    • (2011) Front Biosci , vol.16 , pp. 1413-1427
    • Hiratsuka, S.1
  • 10
    • 34447108810 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: biology and therapeutic applications
    • 10.1016/j.biocel.2007.04.010, 2752727, 17537667
    • Ho QT, Kuo CJ. Vascular endothelial growth factor: biology and therapeutic applications. Int J Biochem Cell Biol 2007, 39:1349-1357. 10.1016/j.biocel.2007.04.010, 2752727, 17537667.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1349-1357
    • Ho, Q.T.1    Kuo, C.J.2
  • 11
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • 10.1038/nrclinonc.2009.130, 19736552
    • Ivy SP, Wichk JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009, 6:569-579. 10.1038/nrclinonc.2009.130, 19736552.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wichk, J.Y.2    Kaufman, B.M.3
  • 12
    • 79957925832 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and receptors: Anti-angiogneic therapy in the treatment of cancer
    • 10.1016/j.mam.2011.04.004, 21565214
    • Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L. Vascular endothelial growth factors and receptors: Anti-angiogneic therapy in the treatment of cancer. Mol Aspects Med 2011, 32:88-111. 10.1016/j.mam.2011.04.004, 21565214.
    • (2011) Mol Aspects Med , vol.32 , pp. 88-111
    • Tugues, S.1    Koch, S.2    Gualandi, L.3    Li, X.4    Claesson-Welsh, L.5
  • 13
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • 10.1016/j.cell.2010.03.015, 2862057, 20371345
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141:52-67. 10.1016/j.cell.2010.03.015, 2862057, 20371345.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 14
    • 57149102486 scopus 로고    scopus 로고
    • Systems biology of vascular endothelial growth factors
    • 10.1080/10739680802095964, 2722038, 18608994
    • Mac Gabhann F, Popel AS. Systems biology of vascular endothelial growth factors. Microcirculation 2008, 15:715-738. 10.1080/10739680802095964, 2722038, 18608994.
    • (2008) Microcirculation , vol.15 , pp. 715-738
    • Mac Gabhann, F.1    Popel, A.S.2
  • 16
    • 77649126707 scopus 로고    scopus 로고
    • Dissecting cancer through mathematics: from the cell to the animal model
    • 10.1038/nrc2808, 20179714
    • Byrne HM. Dissecting cancer through mathematics: from the cell to the animal model. Nat Rev Cancer 2010, 10:221-230. 10.1038/nrc2808, 20179714.
    • (2010) Nat Rev Cancer , vol.10 , pp. 221-230
    • Byrne, H.M.1
  • 17
    • 39749086288 scopus 로고    scopus 로고
    • Integrative mathematical oncology
    • 10.1038/nrc2329, 18273038
    • Anderson ARA, Quaranta V. Integrative mathematical oncology. Nat Rev Cancer 2008, 8:227-234. 10.1038/nrc2329, 18273038.
    • (2008) Nat Rev Cancer , vol.8 , pp. 227-234
    • Anderson, A.R.A.1    Quaranta, V.2
  • 18
    • 57149107582 scopus 로고    scopus 로고
    • Computational and mathematical modeling of angiogenesis
    • Peirce SM. Computational and mathematical modeling of angiogenesis. Microcirculation 2010, 15:739-751.
    • (2010) Microcirculation , vol.15 , pp. 739-751
    • Peirce, S.M.1
  • 20
    • 53549094683 scopus 로고    scopus 로고
    • A compartment model of VEGF distribution in blood, healthy and diseased tissues
    • 10.1186/1752-0509-2-77, 2562372, 18713470
    • Stefanini MO, Wu FTH, Mac Gabhann F, Popel AS. A compartment model of VEGF distribution in blood, healthy and diseased tissues. BMC Systems Biology 2008, 2:77. 10.1186/1752-0509-2-77, 2562372, 18713470.
    • (2008) BMC Systems Biology , vol.2 , pp. 77
    • Stefanini, M.O.1    Wu, F.T.H.2    Mac Gabhann, F.3    Popel, A.S.4
  • 21
    • 78649952814 scopus 로고    scopus 로고
    • Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model
    • 10.1158/0008-5472.CAN-10-1419, 21118974
    • Stefanini MO, Wu FTH, Mac Gabhann F, Popel AS. Increase of plasma VEGF after intravenous administration of bevacizumab is predicted by a pharmacokinetic model. Cancer Res 2010, 70:9886-9894. 10.1158/0008-5472.CAN-10-1419, 21118974.
    • (2010) Cancer Res , vol.70 , pp. 9886-9894
    • Stefanini, M.O.1    Wu, F.T.H.2    Mac Gabhann, F.3    Popel, A.S.4
  • 22
    • 33344474679 scopus 로고    scopus 로고
    • Neuropilins in neoplasms: Expression, regulation, and function
    • 10.1016/j.yexcr.2005.11.024, 16445911
    • Bielenberg DR, Pettaway CA, Takashima S, Klagsbrun M. Neuropilins in neoplasms: Expression, regulation, and function. Exp Cell Res 2006, 312:584-593. 10.1016/j.yexcr.2005.11.024, 16445911.
    • (2006) Exp Cell Res , vol.312 , pp. 584-593
    • Bielenberg, D.R.1    Pettaway, C.A.2    Takashima, S.3    Klagsbrun, M.4
  • 24
    • 0034662608 scopus 로고    scopus 로고
    • Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation
    • Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK. Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation. Cancer Res 2000, 60:4324-4327.
    • (2000) Cancer Res , vol.60 , pp. 4324-4327
    • Leu, A.J.1    Berk, D.A.2    Lymboussaki, A.3    Alitalo, K.4    Jain, R.K.5
  • 26
    • 0345373937 scopus 로고    scopus 로고
    • Modeling the early stages of vascular network assembly
    • 10.1093/emboj/cdg176, 154468, 12682010
    • Serini G, Ambrosi D, Giraudo E, Gamba A, Preziosi L, Bussolino F. Modeling the early stages of vascular network assembly. EMBO J 2003, 22:1771-1779. 10.1093/emboj/cdg176, 154468, 12682010.
    • (2003) EMBO J , vol.22 , pp. 1771-1779
    • Serini, G.1    Ambrosi, D.2    Giraudo, E.3    Gamba, A.4    Preziosi, L.5    Bussolino, F.6
  • 27
    • 77954667182 scopus 로고    scopus 로고
    • Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model
    • Kleinheinz J, Jung S, Wermker K, Fischer C, Joos U. Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model. Head Face Med 2010, 6.
    • (2010) Head Face Med , vol.6
    • Kleinheinz, J.1    Jung, S.2    Wermker, K.3    Fischer, C.4    Joos, U.5
  • 30
    • 0037248459 scopus 로고    scopus 로고
    • Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration
    • 151835, 12511590
    • Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest 2003, 111:71-79. 151835, 12511590.
    • (2003) J Clin Invest , vol.111 , pp. 71-79
    • Majka, S.M.1    Jackson, K.A.2    Kienstra, K.A.3    Majesky, M.W.4    Goodell, M.A.5    Hirschi, K.K.6
  • 31
    • 79952443293 scopus 로고    scopus 로고
    • Quantification and cell-to-cell variation of vascular endothelial growth factor receptors
    • 10.1016/j.yexcr.2010.12.014, 3073416, 21185287
    • Imoukhuede PI, Popel AS. Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Exp Cell Res 2011, 317:955-965. 10.1016/j.yexcr.2010.12.014, 3073416, 21185287.
    • (2011) Exp Cell Res , vol.317 , pp. 955-965
    • Imoukhuede, P.I.1    Popel, A.S.2
  • 32
    • 34548500340 scopus 로고    scopus 로고
    • Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F
    • Geretti E, Shimizu A, Kurschat P, Klagsbrun M. Site-directed mutagenesis in the B-neuropilin-2 domain selectively enhances its affinity to VEGF165, but not to semaphorin 3F. J Biol Chem 2007, 284:25698-25707.
    • (2007) J Biol Chem , vol.284 , pp. 25698-25707
    • Geretti, E.1    Shimizu, A.2    Kurschat, P.3    Klagsbrun, M.4
  • 33
    • 0034674108 scopus 로고    scopus 로고
    • Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF
    • 10.1074/jbc.M909259199, 10748121
    • Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G. Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. J Biol Chem 2000, 275:18040-18045. 10.1074/jbc.M909259199, 10748121.
    • (2000) J Biol Chem , vol.275 , pp. 18040-18045
    • Gluzman-Poltorak, Z.1    Cohen, T.2    Herzog, Y.3    Neufeld, G.4
  • 34
    • 74549170440 scopus 로고    scopus 로고
    • The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling
    • Stefanini MO, Wu FTH, Mac Gabhann F, Popel AS. The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling. PLoS Comp Biol 2009, 5:e1000622.
    • (2009) PLoS Comp Biol , vol.5
    • Stefanini, M.O.1    Wu, F.T.H.2    Mac Gabhann, F.3    Popel, A.S.4
  • 35
    • 0035027615 scopus 로고    scopus 로고
    • Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts
    • 10.1046/j.1525-1438.2001.011002137.x, 11328412
    • Pilch H, Schlenger K, Steiner E, Brockerhoff P, Knapstein P, Vaupel P. Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts. Int J Gynecol Cancer 2001, 11:137-142. 10.1046/j.1525-1438.2001.011002137.x, 11328412.
    • (2001) Int J Gynecol Cancer , vol.11 , pp. 137-142
    • Pilch, H.1    Schlenger, K.2    Steiner, E.3    Brockerhoff, P.4    Knapstein, P.5    Vaupel, P.6
  • 36
    • 0029021223 scopus 로고
    • Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration
    • 10.1111/j.1365-2184.1995.tb00082.x, 7548442
    • Leith JT, Michelson S. Secretion rates and levels of vascular endothelial growth factor in clone A or HCT-8 human colon tumour cells as a function of oxygen concentration. Cell Prolif 1995, 28:415-430. 10.1111/j.1365-2184.1995.tb00082.x, 7548442.
    • (1995) Cell Prolif , vol.28 , pp. 415-430
    • Leith, J.T.1    Michelson, S.2
  • 37
    • 33751579930 scopus 로고    scopus 로고
    • Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma
    • 10.1002/ijc.22217, 17019708
    • Salnikov AV, Heldin N-E, Stuhr LB, Wiig H, Gerber H-P, Reed RK, Rubin K. Inhibition of carcinoma cell-derived VEGF reduces inflammatory characteristics in xenograft carcinoma. Int J Cancer 2006, 119:2795-2802. 10.1002/ijc.22217, 17019708.
    • (2006) Int J Cancer , vol.119 , pp. 2795-2802
    • Salnikov, A.V.1    Heldin, N.-.E.2    Stuhr, L.B.3    Wiig, H.4    Gerber, H.-.P.5    Reed, R.K.6    Rubin, K.7
  • 38
    • 0034283023 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, Interleukin 9, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    • Rofstad EK, Halsor EF. Vascular endothelial growth factor, Interleukin 9, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res 2000, 60:4932-4938.
    • (2000) Cancer Res , vol.60 , pp. 4932-4938
    • Rofstad, E.K.1    Halsor, E.F.2
  • 39
    • 79955616139 scopus 로고    scopus 로고
    • Interstitial fluid: the overlooked component of the tumor microenvironment?
    • 10.1186/1755-1536-3-12, 2920231, 20653943
    • Wiig H, Tenstad O, Iversen PO, Kalluri R, Bjerkvig R. Interstitial fluid: the overlooked component of the tumor microenvironment?. Fibrogenesis Tissue Repair 2010, 3:12. 10.1186/1755-1536-3-12, 2920231, 20653943.
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 12
    • Wiig, H.1    Tenstad, O.2    Iversen, P.O.3    Kalluri, R.4    Bjerkvig, R.5
  • 41
    • 82555177187 scopus 로고    scopus 로고
    • Quantification of VEGF mRNA expression in non-small cell lung cancer using a real-time quantitative reverse transcription-PCR assay and a comparison with quantitative competitive reverse transcription-PCR
    • Yuan A, Yu CJ, Luh KT, Lin FY, Kuo SH, Yang PC. Quantification of VEGF mRNA expression in non-small cell lung cancer using a real-time quantitative reverse transcription-PCR assay and a comparison with quantitative competitive reverse transcription-PCR. Lab Invest 2000, 2000:11.
    • (2000) Lab Invest , vol.2000 , pp. 11
    • Yuan, A.1    Yu, C.J.2    Luh, K.T.3    Lin, F.Y.4    Kuo, S.H.5    Yang, P.C.6
  • 42
    • 0031668734 scopus 로고    scopus 로고
    • Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon
    • 10.1016/S0046-8177(98)90195-2, 9744306
    • Cheung N, Wong MP, Yuen ST, Leung SY, Chung LP. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon. Hum Pathol 1998, 29:910-914. 10.1016/S0046-8177(98)90195-2, 9744306.
    • (1998) Hum Pathol , vol.29 , pp. 910-914
    • Cheung, N.1    Wong, M.P.2    Yuen, S.T.3    Leung, S.Y.4    Chung, L.P.5
  • 43
    • 0242653716 scopus 로고    scopus 로고
    • Tumor vascular endothelial growth factor (VEGF) mRNA in relation to serum VEGF protein levels and tumour progression in human renal cell carcinoma
    • 10.1007/s00240-003-0346-x, 14574539
    • Ljungberg B, Jacobsen J, Haggstrom-Rudolfssson S, Rasmuson T, Lindh G, Grankvist K. Tumor vascular endothelial growth factor (VEGF) mRNA in relation to serum VEGF protein levels and tumour progression in human renal cell carcinoma. Urol Res 2003, 31:335-340. 10.1007/s00240-003-0346-x, 14574539.
    • (2003) Urol Res , vol.31 , pp. 335-340
    • Ljungberg, B.1    Jacobsen, J.2    Haggstrom-Rudolfssson, S.3    Rasmuson, T.4    Lindh, G.5    Grankvist, K.6
  • 44
    • 34547681351 scopus 로고    scopus 로고
    • Quantitative real-time reverse transcription-PCR study of the expression of vascular endothelial growth factor (VEGF) splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) in non-small cell lung cancer
    • 10.1373/clinchem.2007.086819, 17599955
    • Zygalaki E, Tsaroucha EG, Kaklamanis L, Lianidou ES. Quantitative real-time reverse transcription-PCR study of the expression of vascular endothelial growth factor (VEGF) splice variants and VEGF receptors (VEGFR-1 and VEGFR-2) in non-small cell lung cancer. Clin Chem 2007, 53:1433-1439. 10.1373/clinchem.2007.086819, 17599955.
    • (2007) Clin Chem , vol.53 , pp. 1433-1439
    • Zygalaki, E.1    Tsaroucha, E.G.2    Kaklamanis, L.3    Lianidou, E.S.4
  • 45
    • 0035143709 scopus 로고    scopus 로고
    • Differential expression of VEGF isoforms in mouse during development and in the adult
    • 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D, 11169844
    • Ng YS, Rohan R, Sunday ME, Demello DE, D'Amore PA. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 2001, 220:112-121. 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D, 11169844.
    • (2001) Dev Dyn , vol.220 , pp. 112-121
    • Ng, Y.S.1    Rohan, R.2    Sunday, M.E.3    Demello, D.E.4    D'Amore, P.A.5
  • 46
    • 19444386664 scopus 로고    scopus 로고
    • VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise
    • 10.1152/japplphysiol.01402.2004, 15661835
    • Gustafsson T, Ameln H, Fischer H, Sundberg CJ, Timmons JA, Jansson E. VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise. J Appl Physiol 2005, 98:2137-2146. 10.1152/japplphysiol.01402.2004, 15661835.
    • (2005) J Appl Physiol , vol.98 , pp. 2137-2146
    • Gustafsson, T.1    Ameln, H.2    Fischer, H.3    Sundberg, C.J.4    Timmons, J.A.5    Jansson, E.6
  • 47
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, Sledge GW, Holmgren E, Benjamin R, Stalter S, Shak S, Adelman D. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001, 19:843-850.
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3    Sledge, G.W.4    Holmgren, E.5    Benjamin, R.6    Stalter, S.7    Shak, S.8    Adelman, D.9
  • 48
    • 33750319800 scopus 로고    scopus 로고
    • The anti-VEGF antibody bevacizumab potently reduces the growth rate of high-risk neuroblastoma xenografts
    • 10.1203/01.pdr.0000242494.94000.52, 16988184
    • Segerstrom L, Fuchs D, Backman U, Holmquist K, Christofferson R, Azarbayjani F. The anti-VEGF antibody bevacizumab potently reduces the growth rate of high-risk neuroblastoma xenografts. Pediatr Res 2006, 60:576-581. 10.1203/01.pdr.0000242494.94000.52, 16988184.
    • (2006) Pediatr Res , vol.60 , pp. 576-581
    • Segerstrom, L.1    Fuchs, D.2    Backman, U.3    Holmquist, K.4    Christofferson, R.5    Azarbayjani, F.6
  • 49
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a Phase I trial in rectal cancer patients
    • 10.1200/JCO.2005.02.5635, 16258121
    • Willet CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin S, Petit L, Jain RK, Chung DD, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a Phase I trial in rectal cancer patients. J Clin Oncol 2005, 23:8136-8139. 10.1200/JCO.2005.02.5635, 16258121.
    • (2005) J Clin Oncol , vol.23 , pp. 8136-8139
    • Willet, C.G.1    Boucher, Y.2    Duda, D.G.3    di Tomaso, E.4    Munn, L.L.5    Tong, R.T.6    Kozin, S.7    Petit, L.8    Jain, R.K.9    Chung, D.D.10
  • 51
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • 10.1152/physrev.00038.2010, 21742796
    • Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011, 91:1071-1121. 10.1152/physrev.00038.2010, 21742796.
    • (2011) Physiol Rev , vol.91 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6    Jain, R.K.7
  • 52
    • 0032530717 scopus 로고    scopus 로고
    • VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface
    • 10.1016/S0969-2126(98)00116-6, 9753694
    • Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, de Vos AM. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface. Structure 1998, 6:1153-1167. 10.1016/S0969-2126(98)00116-6, 9753694.
    • (1998) Structure , vol.6 , pp. 1153-1167
    • Muller, Y.A.1    Chen, Y.2    Christinger, H.W.3    Li, B.4    Cunningham, B.C.5    Lowman, H.B.6    de Vos, A.M.7
  • 53
    • 33847615623 scopus 로고    scopus 로고
    • Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies
    • 10.1073/pnas.0611492104, 1805509, 17360669
    • Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, et al. Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies. Proc Natl Acad Sci USA 2007, 104:3478-3483. 10.1073/pnas.0611492104, 1805509, 17360669.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3478-3483
    • Gerber, H.P.1    Wu, X.2    Yu, L.3    Wiesmann, C.4    Liang, X.H.5    Lee, C.V.6    Fuh, G.7    Olsson, C.8    Damico, L.9    Xie, D.10
  • 55
    • 70350002279 scopus 로고    scopus 로고
    • Adverse effects of anticancer agents that target the VEGF pathway
    • 10.1038/nrclinonc.2009.94, 19581909
    • Chen HX, Cleck JN. Adverse effects of anticancer agents that target the VEGF pathway. Nat Rev Clin Oncol 2009, 6:465-477. 10.1038/nrclinonc.2009.94, 19581909.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 465-477
    • Chen, H.X.1    Cleck, J.N.2
  • 56
    • 33846025118 scopus 로고    scopus 로고
    • Targeting neuropilin-1 to inhibit VEGF signaling in cancer: comparison of therapeutic approaches
    • Mac Gabhann F, Popel AS. Targeting neuropilin-1 to inhibit VEGF signaling in cancer: comparison of therapeutic approaches. PLoS Comp Biol 2006, 2:e180.
    • (2006) PLoS Comp Biol , vol.2
    • Mac Gabhann, F.1    Popel, A.S.2
  • 57
    • 70349482671 scopus 로고    scopus 로고
    • C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    • 10.1073/pnas.0908201106, 2752543, 19805273
    • Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci USA 2009, 106:16157-16162. 10.1073/pnas.0908201106, 2752543, 19805273.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16157-16162
    • Teesalu, T.1    Sugahara, K.N.2    Kotamraju, V.R.3    Ruoslahti, E.4
  • 58
    • 79959304867 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor therapy for breast cancer: can we pick the winners?
    • 10.1200/JCO.2011.34.9266, 21555698
    • Schneider BP, Sledge GW. Anti-vascular endothelial growth factor therapy for breast cancer: can we pick the winners?. J Clin Oncol 2011, 29:2444-2447. 10.1200/JCO.2011.34.9266, 21555698.
    • (2011) J Clin Oncol , vol.29 , pp. 2444-2447
    • Schneider, B.P.1    Sledge, G.W.2
  • 59
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • 10.1126/science.1104819, 15637262
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62. 10.1126/science.1104819, 15637262.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.