A GC-MS-based metabonomic investigation of blood serum from irritable bowel syndrome patients undergoing intervention with acidified milk products

European Food Research and Technology

Volumn 233, Issue 6, 2011, Pages 1013-1021

  Pedersen, Simon M M ^a,b,f   Nebel, Caroline ^a   Nielsen, Niels Chr ^b   Andersen, Henrik J ^c   Olsson, Johan ^d   Simrén, Magnus ^e   Öhman, Lena ^e   Svensson, Ulla ^c   Bertram, Hanne C ^a   Malmendal, Anders ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c Arla Foods   (Denmark)

^d KPL Good Food Practice AB   (Sweden)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^f AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Acidified milk products; Derivatization; GC MS; Irritable bowel syndrome; Lactate; Metabonomics; Probiotics

Indexed keywords

DERIVATIZATIONS; GC-MS; IRRITABLE BOWEL SYNDROMES; LACTATE; METABONOMICS; MILK PRODUCTS; PROBIOTICS;

AMINO ACIDS; BACILLI; BLOOD; DAIRY PRODUCTS; DISCRIMINANT ANALYSIS; GAS CHROMATOGRAPHY; GLUCOSE; MASS SPECTROMETRY; MULTIVARIANT ANALYSIS; PATIENT TREATMENT;

PRINCIPAL COMPONENT ANALYSIS;

BIFIDOBACTERIUM ANIMALIS; BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS PARACASEI;

EID: 81355160308     PISSN: 14382377     EISSN: 14382385     Source Type: Journal    
DOI: 10.1007/s00217-011-1599-1     Document Type: Article

References (45)

1. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11): 1181-1189.
2. Xiayan L, Legido-Quigley C (2008) Advances in separation science applied to metabonomics. Electrophoresis 29(18): 3724-3736.
3. Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR (2007) An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. J Proteome Res 6(9): 3456-3464.
4. Malmendal A, Overgaard J, Bundy JG, Sorensen JG, Nielsen NC, Loeschcke V, Holmstrup M (2006) Metabolomic profiling of heat stress: hardening and recovery of homeostasis in Drosophila. Am J Physiol Regul Integr Comp Physiol 291(1): R205-R212.
5. Pedersen KS, Kristensen TN, Loeschcke V, Petersen BO, Duus JO, Nielsen NC, Malmendal A (2008) Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster. Genetics 180(2): 1233-1243.
6. Janis MT, Laaksonen R, Oresic M (2008) Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs. Expert Opin Drug Metab Toxicol 4(6): 665-680.
7. Hines A, Oladiran GS, Bignell JP, Stentiford GD, Viant MR (2007) Direct sampling of organisms from the field and knowledge of their phenotype: key recommendations for environmental metabolomics. Environ Sci Technol 41(9): 3375-3381.
8. Bertram HC, Hoppe C, Petersen BO, Duus JO, Molgaard C, Michaelsen KF (2007) An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys. Br J Nutr 97(4): 758-763.
9. Bertram HC, Duarte IF, Gil AM, Knudsen KE, Laerke HN (2007) Metabolic profiling of liver from hypercholesterolemic pigs fed rye or wheat fiber and from normal pigs. High-resolution magic angle spinning 1H NMR spectroscopic study. Anal Chem 79(1): 168-175.
10. Bertram HC, Bach Knudsen KE, Serena A, Malmendal A, Nielsen NC, Frette XC, Andersen HJ (2006) NMR-based metabonomic studies reveal changes in the biochemical profile of plasma and urine from pigs fed high-fibre rye bread. Br J Nutr 95(5): 955-962.
11. Lenz EM, Wilson ID (2007) Analytical strategies in metabonomics. J Proteome Res 6(2): 443-458.
12. Jiye A, Trygg J, Gullberg J, Johansson AI, Jonsson P, Antti H, Marklund SL, Moritz T (2005) Extraction and GC/MS analysis of the human blood plasma metabolome. Anal Chem 77(24): 8086-8094.
13. Pasikanti KK, Ho PC, Chan EC (2008) Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J Chromatogr B Analyt Technol Biomed Life Sci 871(2): 202-211.
14. Qiu Y, Su M, Liu Y, Chen M, Gu J, Zhang J, Jia W (2007) Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling. Anal Chim Acta 583(2): 277-283.
15. Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, Vitali B, Poggioli G, Miglioli M, Campieri M (2003) Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 124(5): 1202-1209.
16. Gosselink MP, Schouten WR, van Lieshout LM, Hop WC, Laman JD, Ruseler-van Embden JG (2004) Delay of the first onset of pouchitis by oral intake of the probiotic strain Lactobacillus rhamnosus GG. Dis Colon Rectum 47(6): 876-884.
17. Kajander K, Hatakka K, Poussa T, Farkkila M, Korpela R (2005) A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention. Aliment Pharmacol Ther 22(5): 387-394.
18. Kajander K, Myllyluoma E, Rajilic-Stojanovic M, Kyronpalo SS, Rasmussen M, Jarvenpaa SS, Zoetendal EG, de Vos WM, Vapaatalo H, Korpela R (2007) Clinical trial: multispecies probiotic supplementation alleviates the symptoms of IBS and stabilises intestinal microbiota. Aliment Pharmacol Ther 27(1): 48-57.
19. Kim HJ, Camilleri M, McKinzie S, Lempke MB, Burton DD, Thomforde GM, Zinsmeister AR (2003) A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 17(7): 895-904.
20. Niedzielin K, Kordecki H, Birkenfeld B (2001) A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299 V in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 13(10): 1143-1147.
21. Akehurst R, Kaltenthaler E (2001) Treatment of irritable bowel syndrome: a review of randomised controlled trials. Gut 48(2): 272-282.
22. Drossman DA, Camilleri M, Mayer EA, Whitehead WE (2002) AGA technical review on irritable bowel syndrome. Gastroenterology 123(6): 2108-2131.
23. Foxx-Orenstein A (2006) IBS-review and what's new. MedGenMed 8(3): 20.
24. Ersryd A, Posserud I, Abrahamsson H, Simren M (2007) Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III. Aliment Pharmacol Ther 26(6): 953-961.
25. Francis CY, Morris J, Whorwell PJ (1997) The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress. Aliment Pharmacol Ther 11(2): 395-402.
26. 1H NMR-based metabonomic analysis. Nutrients 2(11): 1141-1155.
27. Simren M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H (2010) Clinical trial: the effect of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome (IBS)-a randomized, double-blind, controlled study. Aliment Pharmacol Ther 31(2): 218-227.
28. Trygg J, Wold S (2002) Orthogonal projections to latent structures (O-PLS). J Chemometr 16(3): 119-128.
29. Keun HC, Ebbels TMD, Antti H, Bollard ME, Beckonert O, Holmes E, Lindon JC, Nicholson JK (2003) Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling. Anal Chim Acta 490(1-2): 265-276.
30. Wiklund S, Johansson E, Sjostrom L, Mellerowicz EJ, Edlund U, Shockcor JP, Gottfries J, Moritz T, Trygg J (2008) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 80(1): 115-122.
31. Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism. Physiol Rev 80(3): 1107-1213.
32. Enck P, Klosterhalfen S (2005) The placebo response in functional bowel disorders: perspectives and putative mechanisms. Neurogastroenterol Motil 17(3): 325-331.
33. Kreisberg RA (1980) Lactate homeostasis and lactic acidosis. Ann Intern Med 92(2 Pt 1): 227-237.
34. Pitz M, Cheang M, Bernstein CN (2005) Defining the predictors of the placebo response in irritable bowel syndrome. Clin Gastroenterol Hepatol 3(3): 237-247.
35. Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P (2009) A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 9: 15.
36. Daly M (2003) Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr 78(4): 865S-872S.
37. Daly ME, Vale C, Walker M, Littlefield A, Alberti KG, Mathers JC (1998) Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet. Am J Clin Nutr 67(6): 1186-1196.
38. DeFronzo RA, Ferrannini E (1982) Influence of plasma glucose and insulin concentration on plasma glucose clearance in man. Diabetes 31(8 Pt 1): 683-688.
39. Schenk S, Davidson CJ, Zderic TW, Byerley LO, Coyle EF (2003) Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue. Am J Clin Nutr 78(4): 742-748.
40. Ostman EM, Liljeberg Elmstahl HG, Bjorck IM (2001) Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. Am J Clin Nutr 74(1): 96-100.
41. Watford M (2008) Glutamine metabolism and function in relation to proline synthesis and the safety of glutamine and proline supplementation. J Nutr 138(10): 2003S-2007S.
42. Bertolo RF, Brunton JA, Pencharz PB, Ball RO (2003) Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. Am J Physiol Endocrinol Metab 284(5): E915-E922.
43. Fujita T, Yanaga K (2007) Association between glutamine extraction and release of citrulline and glycine by the human small intestine. Life Sci 80(20): 1846-1850.
44. Burtscher M, Brunner F, Faulhaber M, Hotter B, Likar R (2005) The prolonged intake of l-arginine-l-aspartate reduces blood lactate accumulation and oxygen consumption during submaximal exercise. J Sports Sci Med 4(3): 314-322.
45. Lancha AH Jr, Recco MB, Abdalla DS, Curi R (1995) Effect of aspartate, asparagine, and carnitine supplementation in the diet on metabolism of skeletal muscle during a moderate exercise. Physiol Behav 57(2): 367-371.