Pax8 detection in well-differentiated pancreatic endocrine tumors: How reliable is it?

American Journal of Surgical Pathology

Volumn 35, Issue 12, 2011, Pages 1906-1908

  Moreno, Carmen M Jimenez ^a   Lorenzo, Petra I ^a   Delgado, Irene ^a   Cobo Vuilleumier, Nadia ^a   Gomez Izquierdo, Lourdes ^b   Garcia Carbonero, Rocio ^c   Rojas, Anabel ^a   Gauthier, Benoit R ^a  

^a CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^b Servicio de Anatomia Patologica   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PAIRED BOX TRANSCRIPTION FACTOR;

CARCINOID; FEMALE; GASTROINTESTINAL TUMOR; HUMAN; LETTER; LUNG TUMOR; MALE; METABOLISM; METASTASIS; PANCREAS ISLET CELL CARCINOMA; PANCREAS ISLET CELL TUMOR; PANCREAS TUMOR; PATHOLOGY;

ADENOMA, ISLET CELL; CARCINOID TUMOR; CARCINOMA, ISLET CELL; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; LUNG NEOPLASMS; MALE; PAIRED BOX TRANSCRIPTION FACTORS; PANCREATIC NEOPLASMS;

EID: 81355138970     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3182390774     Document Type: Letter

References (11)

1. Bloomston M, Durkin A, Yang I, et al. Identification of molecular markers specific for pancreatic neuroendocrine tumors by genetic profiling of core biopsies. Ann Surg Oncol. 2004;11:413-419. (Pubitemid 40486752)
2. Garcia-Carbonero R, Capdevila J, Crespo-Herrero G, et al. Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE). Ann Oncol. 2010;21:1794-1803.
3. Garcia-Carbonero R, Salazar R, Sevilla I, et al. SEOM clinical guidelines for the diagnosis and treatment of gastroenteropancreatic neuroendocrine tumours (GEP NETS). Clin Transl Oncol. 2011;13:545-551.
4. Goode DK, Elgar G. The PAX258 gene subfamily: a comparative perspective. Dev Dyn. 2009;238:2951-2974.
5. Haynes CM, Sangoi AR, Pai RK. PAX8 is expressed in pancreatic well-differentiated neuroendocrine tumors and in extrapancreatic poorly differentiated neuroendocrine carcinomas in fine-needle aspiration biopsy specimens. Cancer Cytopathol. 2011;119: 193-201.
6. Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816-826.
7. Long KB, Srivastava A, Hirsch MS, et al. PAX8 expression in well-differentiated pancreatic endocrine tumors: correlation with clinicopathologic features and comparison with gastrointestinal and pulmonary carcinoid tumors. Am J Surg Pathol. 2010;34:723-729.
8. Lorenzo PI, Jimenez Moreno CM, Delgado I, et al. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine. Tumors Histochem Cell Biol. (In press).
9. Morgenstern DA, Hasan F, Gibson S, et al. PAX5 expression in nonhematopoietic tissues: reappraisal of previous studies. Am J Clin Pathol. 2010;133:407-415.
10. Poleev A, Wendler F, Fickenscher H, et al. Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. Eur J Biochem. 1995;228:899-911.
11. Sangoi AR, Ohgami RS, Pai RK, et al. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol. 2011;24:412-424.