PAX5 Expression in nonhematopoietic tissues reappraisal of previous studies

American Journal of Clinical Pathology

Volumn 133, Issue 3, 2010, Pages 407-415

  Morgenstern, Daniel A ^a   Hasan, Fyeza ^a   Gibson, Sian ^c   Winyard, Paul ^b   Sebire, Neil J ^c   Anderson, John ^a,d  

^a Unit of Molecular Haematology and Cancer Biology   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Histopathology Department   (United Kingdom)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

Antibody; Immunohistochemistry; Monoclonal; PAX2; PAX5; Wilms tumor

Indexed keywords

MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR PAX5; MESSENGER RNA; PAX5 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; CONTROLLED STUDY; CROSS REACTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEPHROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTIBODY SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; MESOBLASTIC NEPHROMA; METABOLISM; NEUROECTODERM TUMOR; OSTEOSARCOMA; RHABDOID TUMOR; RHABDOMYOSARCOMA; SARCOMA; TISSUE MICROARRAY;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; B-CELL-SPECIFIC ACTIVATOR PROTEIN; BLOTTING, WESTERN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; NEOPLASM PROTEINS; NEPHROMA, MESOBLASTIC; NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL; OSTEOSARCOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOID TUMOR; RHABDOMYOSARCOMA; RNA, MESSENGER; SARCOMA; TISSUE ARRAY ANALYSIS; WILMS TUMOR;

EID: 77949398395     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCPZPQN0LUGKMME     Document Type: Article

References (35)

1. Lang D, Powell SK, Plummer RS, et al. PAX genes: roles in development, pathophysiology, and cancer. Biochem Pharmacol. 2007;73:1-14. (Pubitemid 44868976)
2. Robson E, He S, Eccles M. A PANorama of PAX genes in cancer and development. Nat Rev Cancer. 2006;6:52-62. (Pubitemid 43053651)
3. Sorensen PH, Lynch JC, Qualman S, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2002;20:2672-2679. (Pubitemid 34575640)
4. Nabarro S, Himoudi N, Papanastasiou A, et al. Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein. J Exp Med. 2005;202:1399-1410. (Pubitemid 41668742)
5. Feldman AL, Dogan A. Diagnostic uses of Pax5 immunohistochemistry. Adv Anat Pathol. 2007;14:323-334.
6. Jensen KC, Higgins JP, Montgomery K, et al. The utility of PAX5 immunohistochemistry in the diagnosis of undifferentiated malignant neoplasms. Mod Pathol. 2007;20:871-877. (Pubitemid 47077271)
7. Torlakovic E, Torlakovic G, Nguyen PL, et al. The value of anti - pax-5 immunostaining in routinely fixed and paraffin-embedded sections: a novel pan pre-B and B-cell marker. Am J Surg Pathol. 2002;26:1343-1350.
8. Yan M, Himoudi N, Pule M, et al. Development of cellular immune responses against PAX5, a novel target for cancer immunotherapy. Cancer Res. 2008;68:8058-8065.
9. Morgenstern DA, Gibson S, Sebire N, et al. PAX5 expression in rhabdomyosarcoma [published online ahead of print July 7, 2009]. Am J Surg Pathol. doi:10.1097/PAS.0b013e3181abe137.
10. Eccles MR, Yun K, Reeve AE, et al. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol. 1995;146:40-45.
11. Eccles MR, Wallis LJ, Fidler AE, et al. Expression of the PAX2 gene in human fetal kidney and Wilms' tumor. Cell Growth Differ. 1992;3:279-289.
12. Winyard PJ, Risdon RA, Sams VR, et al. The PAX2 transcription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest. 1996;98:451-459.
13. Sullivan LM, Atkins KA, LeGallo RD. PAX immunoreactivity identifies alveolar rhabdomyosarcoma. Am J Surg Pathol. 2009;33:775-780.
14. Adams B, Dorfler P, Aguzzi A, et al. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992;6:1589-1607.
15. Urbánek P, Wang ZQ, Fetka I, et al. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell. 1994;79:901-912. (Pubitemid 24371980)
16. Dressler GR, Douglass EC. Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sci U S A. 1992;89:1179-1183.
17. Phelps DE, Dressler GR. Identification of novel Pax-2 binding sites by chromatin precipitation. J Biol Chem. 1996;271:7978-7985.
18. Torlakovic E, Slipicevic A, Robinson C, et al. Pax-5 expression in nonhematopoietic tissues. Am J Clin Pathol. 2006;126:798-804.
19. Oefelein M, Grapey D, Schaeffer T, et al. Pax-2: a developmental gene constitutively expressed in the mouse epididymis and ductus deferens. J Urol. 1996;156:1204-1207. (Pubitemid 26269857)
20. Dressler GR, Deutsch U, Chowdhury K, et al. Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development. 1990;109:787-795. (Pubitemid 20267191)
21. Kuschert S, Rowitch DH, Haenig B, et al. Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives. Dev Biol. 2001;229:128-140. (Pubitemid 32061719)
22. Torres M, Gómez-Pardo E, Dressler GR, et al. Pax-2 controls multiple steps of urogenital development. Development. 1995;121:4057-4065. (Pubitemid 26007357)
23. Mhawech-Fauceglia P, Saxena R, Zhang S, et al. Pax-5 immunoexpression in various types of benign and malignant tumors: a high-throughput tissue microarray analysis. J Clin Pathol. 2007;60:709-714. (Pubitemid 46975231)
24. Dong HY, Liu W, Cohen P, et al. B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in Merkel cell carcinoma and small cell carcinomas. Am J Surg Pathol. 2005;29:687-692. (Pubitemid 40577881)
25. Kanteti R, Nallasura V, Loganathan S, et al. PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription. Lab Invest. 2009;89:301-314.
26. Wagner P, Kitabayashi N, Chen Y, et al. Combined small cell lung carcinomas: genotypic and immunophenotypic analysis of the separate morphologic components. Am J Clin Pathol. 2009;131:376-382.
27. Baumann Kubetzko FB, Di Paolo C, Maag C, et al. The PAX5 oncogene is expressed in N-type neuroblastoma cells and increases tumorigenicity of a S-type cell line. Carcinogenesis. 2004;25:1839-1846. (Pubitemid 39405902)
28. Myers L, Atkins K, LeGallo R. PAX5 immunoreactivity in pediatric small blue cell tumors. Presented at the Society for Pediatric Pathology Annual Meeting; March 24-25, 2007; San Diego, CA. http://www.spponline.org/ abstracts2007.pdf. Accessed January 14, 2010.
29. Adshead JM, Ogden CW, Penny MA, et al. The expression of PAX5 in human transitional cell carcinoma of the bladder: relationship with de-differentiation. BJU Int. 1999;83:1039-1044. (Pubitemid 29271876)
30. Babjuk M, Soukup V, Mares J, et al. Association of PAX5 expression with clinical outcome in patients with TaT1 transitional cell carcinoma of the bladder. Urology. 2006;67:756-761.
31. Denzinger S, Burger M, Hammerschmied C, et al. Pax-5 protein expression in bladder cancer: a preliminary study that shows no correlation to grade, stage or clinical outcome. Pathology. 2008;40:465-469. (Pubitemid 351950878)
32. Muratovska A, Zhou C, He S, et al. Paired-box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene. 2003;22:7989-7997. (Pubitemid 37179944)
33. Stuart ET, Kioussi C, Aguzzi A, et al. PAX5 expression correlates with increasing malignancy in human astrocytomas. Clin Cancer Res. 1995;1:207-214.
34. Kozmik Z, Sure U, Rüedi D, et al. Deregulated expression of PAX5 in medulloblastoma. Proc Natl Acad Sci U S A. 1995;92:5709-5713.
35. Sica G, Vazquez M, Altorki N, et al. PAX-5 expression in pulmonary neuroendocrine neoplasms: its usefulness in surgical and fine-needle aspiration biopsy specimens. Am J Clin Pathol. 2008;129:556-562. (Pubitemid 352029274)