Challenges in periprosthetic knee-joint infection

International Journal of Artificial Organs

Volumn 34, Issue 9, 2011, Pages 947-956

  Sendi, Parham ^a,b,c   Zimmerli, Werner ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Debridement with retention; Hematogenous infection; Periprosthetic joint infection; Spacer; Total knee arthroplasty

Indexed keywords

JOINTS (ANATOMY); ORTHOPEDICS; RISK PERCEPTION;

ANTIMICROBIAL THERAPY; COMORBIDITIES; DEBRIDEMENT; DEBRIDEMENT WITH RETENTION; HEMATOGENOUS INFECTION; KNEE ARTHROPLASTY; KNEE JOINT; PERIPROSTHETIC JOINT INFECTION; RISK FACTORS; TOTAL KNEE ARTHROPLASTY;

ARTHROPLASTY;

ANTIMICROBIAL THERAPY; ARTHRITIS; ARTHRODESIS; ARTHROSCOPIC DEBRIDEMENT; DEBRIDEMENT; DEVICE REMOVAL; DIABETES MELLITUS; FOLLOW UP; GENDER; HUMAN; INFECTION RATE; KNEE FRACTURE; OBESITY; PERIOPERATIVE PERIOD; PERIPROSTHETIC JOINT INFECTION; POSTOPERATIVE PERIOD; PROSTHESIS INFECTION; REVIEW; RHEUMATOID ARTHRITIS; RISK FACTOR; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; TOTAL KNEE REPLACEMENT; TREATMENT DURATION;

EID: 81355132350     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/ijao.5000032     Document Type: Review

References (99)

1. Vastag B. Knee replacement underused, says panel: useful option when nonsurgical therapies fail. JAMA. 2004;291:413-414.
2. Shah AK, Celestin J, Parks ML, Levy RN. Long-term results of total joint arthroplasty in elderly patients who are frail. Clin Orthop Relat Res. 2004:106-109.
3. Hall M, DeFrances C, Williams N, Golosinskiy A, Schwartzman A. Division of Health Care Statistics, National Hospital Discharge Survey: 2007 Summary. National Health Statistic Reports 2010;29. http://www.cdc.gov/nchs/data/nhsr/ nhsr029.pdf. Accessed May 26, 2011.
4. Canadian Institute for Health Information. Canadian Joint Replacement Registry. Hip and Knee Replacements in Canada 2008-2009 Annual Report. http://secure.cihi.ca/cihiweb/products/2008_cjrr_annual_report_en.pdf. Accessed May 26, 2011.
5. Australian Orthopaedic Association: National Joint Replacement Registry. Demographics of Hip & Knee Arthroplasty. Supplementary Report 2010. http://www.dmac.adelaide.edu.au/aoanjrr/documents/HipKneeDemographicsReport_2010.pdf. Accessed May 26, 2011.
6. National Joint Registry. http://www.njrcentre.org.uk/njrcentre/Healthcareproviders/Accessingthedata/StatsOnline/NJRStatsOnline/tabid/179/Default.aspx. Accessed May 26, 2011.
7. Jämsen E, Huotari K, Huhtala H, Nevalainen J, Konttinen YT. Low rate of infected knee replacements in a nationwide series--is it an underestimate? Acta Orthop. 2009;80(2):205-212.
8. The Swedish Knee Arthoplasty Register: Annual Report 2010. http://www.knee.nko.se/english/online/thePages/index.php. Accessed May 26 2011.
9. Elek SD, Conen PE. The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection. Br J Exp Pathol. 1957;38:573-586.
10. Zimmerli W, Waldvogel FA, Vaudaux P, Nydegger UE. Pathogenesis of foreign body infection: description and characteristics of an animal model. J Infect Dis. 1982;146:487-497.
11. Zimmerli W, Lew PD, Waldvogel FA. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. J Clin Invest. 1984;73:1191-1200.
12. Zimmerli W, Sendi P. Pathogenesis of implant-associated infection: the role of the host. Semin Immunopathol. 2011;33(3):295-306.
13. Sendi P, Banderet F, Graber P, Zimmerli W. Clinical comparison between exogenous and haematogenous periprosthetic joint infections caused by Staphylococcus aureus. Clin Microbiol Infect. 2011;17(7):1098-1100.
14. Sendi P, Banderet F, Graber P, Zimmerli W. Periprosthetic joint infection following Staphylococcus aureus Bacteremia. J Infect. 2011;63(1):17-22.
15. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351:1645-1654.
16. Jamsen E, Varonen M, Huhtala H, et al. Incidence of prosthetic joint infections after primary knee arthroplasty. J Arthroplasty. 2010;25:87-92.
17. Huotari K, Lyytikainen O, Ollgren J, et al. Disease burden of prosthetic joint infections after hip and knee joint replacement in Finland during 1999-2004: capture-recapture estimation. J Hosp Infect. 2010;75:205-208.
18. Kurtz SM, Ong KL, Lau E, Bozic KJ, Berry D, Parvizi J. Prosthetic joint infection risk after TKA in the Medicare population. Clin Orthop Relat Res. 2010;468:52-56.
19. Del Pozo JL, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med. 2009;361:787-794.
20. Jamsen E, Huhtala H, Puolakka T, Moilanen T. Risk factors for infection after knee arthroplasty. A register-based analysis of 43,149 cases. J Bone Joint Surg Am. 2009;91:38-47.
21. Lalani T, Chu VH, Grussemeyer CA, et al. Clinical outcomes and costs among patients with Staphylococcus aureus bacteremia and orthopedic device infections. Scand J Infect Dis. 2008;40:973-977.
22. Murdoch DR, Roberts SA, Fowler Jr VG, et al. Infection of orthopedic prostheses after Staphylococcus aureus bacteremia. Clin Infect Dis. 2001;32:647-649.
23. Berbari EF, Hanssen AD, Duffy MC, et al. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis. 1998;27:1247-1254.
24. Phillips JE, Crane TP, Noy M, Elliott TS, Grimer RJ. The incidence of deep prosthetic infections in a specialist orthopaedic hospital:a 15-year prospective survey. J Bone Joint Surg Br. 2006;88:943-948.
25. Moran E, Masters S, Berendt AR, McLardy-Smith P, Byren I, Atkins BL. Guiding empirical antibiotic therapy in orthopaedics: The microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention. J Infect. 2007;55:1-7.
26. Sharma D, Douglas J, Coulter C, Weinrauch P, Crawford R. Microbiology of infected arthroplasty:implications for empiric peri-operative antibiotics. J Orthop Surg (Hong Kong). 2008;16:339-342.
27. Aboltins CA, Dowsey MM, Buising KL, et al. Gram-negative prosthetic joint infection treated with debridement, prosthesis retention and antibiotic regimens including a fluoroquinolone. Clin Microbiol Infect. 2011;17(6):862-867.
28. Martinez-Pastor JC, Munoz-Mahamud E, Vilchez F, et al. Outcome of acute prosthetic joint infections due to gramnegative bacilli treated with open debridement and re tention of the prosthesis. Antimicrob Agents Chemother. 2009;53:4772-4777.
29. Zappe B, Graf S, Ochsner PE, Zimmerli W, Sendi P. Propionibacterium spp. in prosthetic joint infections: a diagnostic challenge. Arch Orthop Trauma Surg. 2008;128:1039-46.
30. Rodriguez D, Pigrau C, Euba G, et al. Acute haematogenous prosthetic joint infection: prospective evaluation of medical and surgical management. Clin Microbiol Infect. 2010;16:1789-1795.
31. Peersman G, Laskin R, Davis J, Peterson M. Infection in total knee replacement: a retrospective review of 6489 total knee replacements. Clin Orthop Relat Res. 2001:15-23.
32. Uckay I, Lubbeke A, Emonet S, et al. Low incidence of haematogenous seeding to total hip and knee prostheses in patients with remote infections. J Infect. 2009;59:337-345.
33. Laffer RR, Graber P, Ochsner PE, Zimmerli W. Outcome of prosthetic knee-associated infection:evaluation of 40 consecutive episodes at a single centre. Clin Microbiol Infect. 2006;12:433-439.
34. Espersen F, Frimodt-Moller N, Thamdrup Rosdahl V, Skinhoj P, Bentzon MW. Changing pattern of bone and joint infections due to Staphylococcus aureus: study of cases of bacteremia in Denmark, 1959-1988. Rev Infect Dis. 1991;13:347-358.
35. Lautenschlager S, Herzog C, Zimmerli W. Course and outcome of bacteremia due to Staphylococcus aureus:evaluation of different clinical case definitions. Clin Infect Dis. 1993;16:567-573.
36. Ghanem GA, Boktour M, Warneke C, et al. Catheter-related Staphylococcus aureus bacteremia in cancer patients:high rate of complications with therapeutic implications. Medicine (Baltimore). 2007;86:54-60.
37. Shirtliff ME, Mader JT. Acute septic arthritis. Clin Microbiol Rev. 2002;15:527-44.
38. Zimmerli W, Zak O, Vosbeck K. Experimental hematogenous infection of subcutaneously implanted foreign bodies. Scand J Infect Dis. 1985;17:303-310.
39. Barrack RL, Engh G, Rorabeck C, Sawhney J, Woolfrey M. Patient satisfaction and outcome after septic versus aseptic revision total knee arthroplasty. J Arthroplasty. 2000;15(8):990-993.
40. De Man FH, Sendi P, Zimmerli W, Maurer TB, Ochsner PE, Ilchmann T. Infectiological, functional, and radiographic outcome after revision for prosthetic hip infection according to a strict algorithm. Acta Orthop. 2011;82:27-34.
41. Sendi P, Christensson B, Uckay I, et al. Group B streptococcus in prosthetic hip and knee joint-associated infections. J Hosp Infect. 2011;79(1):64-69.
42. Meehan AM, Osmon DR, Duffy MC, Hanssen AD, Keating MR. Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. Clin Infect Dis. 2003;36:845-849.
43. Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE. Role of rifampin for treatment of orthopedic implant-related staphylococcal infections:a randomized controlled trial. Foreign- Body Infection (FBI) Study Group. JAMA. 1998;279:1537-1541.
44. Burger RR, Basch T, Hopson CN. Implant salvage in infected total knee arthroplasty. Clin Orthop Relat Res. 1991:105-112.
45. Berbari EF, Marculescu C, Sia I, et al. Culture-negative prosthetic joint infection. Clin Infect Dis. 2007;45:1113-1119.
46. Mont MA, Waldman B, Banerjee C, Pacheco IH, Hungerford DS. Multiple irrigation, debridement, and retention of components in infected total knee arthroplasty. J Arthroplasty. 1997;12:426-433.
47. Tattevin P, Cremieux AC, Pottier P, Huten D, Carbon C. Prosthetic joint infection:when can prosthesis salvage be considered? Clin Infect Dis. 1999;29:292-295.
48. Silva M, Tharani R, Schmalzried TP. Results of direct exchange or debridement of the infected total knee arthroplasty. Clin Orthop Relat Res. 2002:125-131.
49. Marculescu CE, Berbari EF, Hanssen AD, et al. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006;42:471-478.
50. Dixon P, Parish EN, Cross MJ. Arthroscopic debridement in the treatment of the infected total knee replacement. J Bone Joint Surg Br. 2004;86:39-42.
51. Waldman BJ, Hostin E, Mont MA, Hungerford DS. Infected total knee arthroplasty treated by arthroscopic irrigation and debridement. J Arthroplasty. 2000;15:430-436.
52. Byren I, Bejon P, Atkins BL, et al. One hundred and twelve infected arthroplasties treated with 'DAIR' (debridement, antibiotics and implant retention):antibiotic duration and outcome. J Antimicrob Chemother. 2009;63:1264-1271.
53. Ilahi OA, Al-Habbal GA, Bocell JR, Tullos HS, Huo MH. Arthroscopic debridement of acute periprosthetic septic arthritis of the knee. Arthroscopy. 2005;21:303-306.
54. Gardner J, Gioe TJ, Tatman P. Can this prosthesis be saved? Implant salvage attempts in infected primary TKA. Clin Orthop Relat Res. 2011;469:970-976.
55. Trampuz A, Piper KE, Jacobson MJ, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007;357:654-663.
56. Zimmerli W, Frei R, Widmer AF, Rajacic Z. Microbiological tests to predict treatment outcome in experimental devicerelated infections due to Staphylococcus aureus. J Antimicrob Chemother. 1994;33:959-967.
57. Widmer AF, Wiestner A, Frei R, Zimmerli W. Killing of nongrowing and adherent Escherichia coli determines drug efficacy in device-related infections. Antimicrob Agents Chemother. 1991;35:741-746.
58. Insall JN, Thompson FM, Brause BD. Two-stage reimplantation for the salvage of infected total knee arthroplasty. J Bone Joint Surg Am. 1983;65:1087-1098.
59. Buchholz H, Gartmann H. Infection prevention and surgical management of deep insidious infection in total endoprosthesis. Chirurg. 1972;43:446-453.
60. Ger E, Dall D, Forder A, Miles T. Bone cement and antibiot ics. S Afr Med J. 1975;49:252. Letter.
61. Elson RA, Jephcott AE, McGechie DB, Verettas D. Antibioticloaded acrylic cement. J Bone Joint Surg Br. 1977;59:200-205.
62. Cohen JC, Hozack WJ, Cuckler JM, Booth RE. Two-stage reimplantation of septic total knee arthroplasty. Report of three cases using an antibiotic-PMMA spacer block. J Arthroplasty. 1988;3:369-377.
63. Calton TF, Fehring TK, Griffin WL. Bone loss associated with the use of spacer blocks in infected total knee arthroplasty. Clin Orthop Relat Res. 1997:148-154.
64. Fehring TK, Odum S, Calton TF, Mason JB. Articulating versus static spacers in revision total knee arthroplasty for sepsis. The Ranawat Award. Clin Orthop Relat Res. 2000:9-16.
65. Booth RE, Lotke PA. The results of spacer block technique in revision of infected total knee arthroplasty. Clin Orthop Relat Res. 1989:57-60.
66. Hofmann AA, Kane KR, Tkach TK, Plaster RL, Camargo MP. Treatment of infected total knee arthroplasty using an articulating spacer. Clin Orthop Relat Res. 1995:45-54.
67. McPherson EJ, Lewonowski K, Dorr LD. Techniques in arthroplasty. Use of an articulated PMMA spacer in the infected total knee arthroplasty. J Arthroplasty. 1995;10:87-9.
68. Masri B, Kendall R, Duncan C, Beauchamp C, McGraw RW, Bora B. Two-stage exchange arthroplasty using a functional antibiotic-loaded spacer in the treatment of the infected knee replacement:the Vancouver experience. Semin Arthroplasty. 1994;5:122-136.
69. Ha CW. A technique for intraoperative construction of antibiotic spacers. Clin Orthop Relat Res. 2006;445:204-209.
70. Hofmann AA, Goldberg T, Tanner AM, Kurtin SM. Treatment of infected total knee arthroplasty using an articulating spacer:2- to 12-year experience. Clin Orthop Relat Res. 2005:125-131.
71. Goldstein WM, Kopplin M, Wall R, Berland K. Temporary articulating methylmethacrylate antibiotic spacer (TAMMAS). A new method of intraoperative manufacturing of a custom articulating spacer. J Bone Joint Surg Am. 2001;83-A Suppl 2 Pt 2:92-97.
72. Durbhakula SM, Czajka J, Fuchs MD, Uhl RL. Antibiotic- loaded articulating cement spacer in the 2-stage exchange of infected total knee arthroplasty. J Arthroplasty. 2004;19:768-774.
73. Hanssen AD, Spangehl MJ. Practical applications of antibiotic- loaded bone cement for treatment of infected joint replacements. Clin Orthop Relat Res. 2004:79-85.
74. MacAvoy MC, Ries M. The ball and socket articulating spacer for infected total knee arthroplasty. J Arthroplasty. 2005;20:757-762.
75. Huang HT, Su JY, Chen SK. The results of articulating spacer technique for infected total knee arthroplasty. J Arthroplasty. 2006;21:1163-1168.
76. Bertazzoni Minelli E, Benini A, Magnan B, Bartolozzi P. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother. 2004;53:329-334.
77. Stevens CM, Tetsworth KD, Calhoun JH, Mader JT. An articulated antibiotic spacer used for infected total knee arthroplasty:a comparative in vitro elution study of Simplex and Palacos bone cements. J Orthop Res. 2005;23:27-33.
78. Ismael F, Bleton R, Saleh-Mghir A, Dautrey S, Massias L, Cremieux AC. Teicoplanin-containing cement spacers for treatment of experimental Staphylococcus aureus joint prosthesis infection. Antimicrob Agents Chemother. 2003;47:3365-3367.
79. Andollina A, Bertoni G, Zolezzi C, et al. Vancomycin and meropenem in acrylic cement:elution kinetics of in vitro bactericidal action. Chir Organi Mov. 2008;91:153-158.
80. Anagnostakos K, Kelm J, Grun S, Schmitt E, Jung W, Swoboda S. Antimicrobial properties and elution kinetics of linezolid- loaded hip spacers in vitro. J Biomed Mater Res B Appl Biomater. 2008;87:173-178.
81. Neut D, de Groot EP, Kowalski RS, van Horn JR, van der Mei HC, Busscher HJ. Gentamicin-loaded bone cement with clindamycin or fusidic acid added:biofilm formation and antibiotic release. J Biomed Mater Res A. 2005;73:165-70.
82. Goss B, Lutton C, Weinrauch P, Jabur M, Gillett G, Crawford R. Elution and mechanical properties of antifungal bone cement. J Arthroplasty. 2007;22:902-908.
83. Anagnostakos K, Kelm J, Regitz T, Schmitt E, Jung W. In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers. J Biomed Mater Res B Appl Biomater. 2005;72:373-378.
84. Streuli JC, Exner GU, Reize CL, Merkofer C, Scott CP, Zbinden R. In vitro inhibition of coagulase-negative staphylococci by vancomycin/aminoglycoside-loaded cement spacers. Infection. 2006;34:81-86.
85. Neut D, van de Belt H, Stokroos I, van Horn JR, van der Mei HC, Busscher HJ. Biomaterial-associated infection of gentamicin- loaded PMMA beads in orthopaedic revision surgery. J Antimicrob Chemother. 2001;47:885-891.
86. Hendriks JG, Neut D, van Horn JR, van der Mei HC, Busscher HJ. Bacterial survival in the interfacial gap in gentamicin- loaded acrylic bone cements. J Bone Joint Surg Br. 2005;87:272-276.
87. Thomes B, Murray P, Bouchier-Hayes D. Development of resistant strains of Staphylococcus epidermidis on gentamicin- loaded bone cement in vivo. J Bone Joint Surg Br. 2002;84:758-760.
88. Jamsen E, Stogiannidis I, Malmivaara A, Pajamaki J, Puo lakka T, Konttinen YT. Outcome of prosthesis exchange for infected knee arthroplasty: the effect of treatment approach. Acta Orthop. 2009;80:67-77.
89. Bamberger D, Foxworth J, Bridwell D, Shain CG, Gerding DN. Extravascular Antimicrobial Distribution and the Respective Blood and Urine. In: Lorian V, eds. Antibiotics in Laboratory Medicine, 5th Edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2005: 719-814.
90. van Raaij TM, Visser LE, Vulto AG, Verhaar JA. Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty. J Arthroplasty. 2002;17:948-950.
91. Springer BD, Lee GC, Osmon D, Haidukewych GJ, Hanssen AD, Jacofsky DJ. Systemic safety of high-dose antibioticloaded cement spacers after resection of an infected total knee arthroplasty. Clin Orthop Relat Res. 2004:47-51.
92. Sendi P, Rohrbach M, Graber P, Frei R, Ochsner PE, Zimmerli W. Staphylococcus aureus small colony variants in prosthetic joint infection. Clin Infect Dis. 2006;43:961-967.
93. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment. Drugs. 2006;66:1089-1105.
94. Drancourt M, Stein A, Argenson JN, Zannier A, Curvale G, Raoult D. Oral rifampin plus ofloxacin for treatment of Staphylococcus- infected orthopedic implants. Antimicrob Agents Chemother. 1993;37:1214-1218.
95. Bernard L, Legout L, Zurcher-Pfund L, et al. Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty. J Infect. 2010;61:125-132.
96. Hsieh PH, Huang KC, Lee PC, Lee MS. Two-stage revision of infected hip arthroplasty using an antibiotic-loaded spacer: retrospective comparison between short-term and prolonged antibiotic therapy. J Antimicrob Chemother. 2009;64:392-397.
97. Barberan J, Aguilar L, Carroquino G, et al. Conservative treatment of staphylococcal prosthetic joint infections in elderly patients. Am J Med. 2006;119:993.e7-10.
98. Vilchez F, Martinez-Pastor JC, Garcia-Ramiro S, et al. Outcome and predictors of treatment failure in early postsurgical prosthetic joint infections due to Staphylococcus aureus treated with debridement. Clin Microbiol Infect. 2011;17:439-444.
99. Hsieh PH, Lee MS, Hsu KY, Chang YH, Shih HN, Ueng SW. Gram-negative prosthetic joint infections:risk factors and outcome of treatment. Clin Infect Dis. 2009;49:1036-1043.