Substitute of animals in drug research: An approach towards fulfillment of 4R′s

Indian Journal of Pharmaceutical Sciences

Volumn 73, Issue 1, 2011, Pages 1-6

  Arora, T ^a   Mehta, A ^a   Joshi, V ^a   Mehta, K ^a   Rathor, N ^a   Mediratta, P ^a   Sharma, K ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Alternatives; DNA chips; In silico analysis; Micro dosing; Micro fluidics

Indexed keywords

COMPUTER ANALYSIS; COST CONTROL; DNA MICROARRAY; DOPAMINERGIC NERVE CELL; DRUG METABOLISM; DRUG RESEARCH; DRUG RESPONSE; DRUG SCREENING; EPIDEMIOLOGICAL DATA; EXPERIMENTAL MODEL; HEALTH SURVEY; HUMAN; IMAGING; MATHEMATICAL ANALYSIS; MICROBIOLOGICAL PHENOMENA AND FUNCTIONS; MICROFLUIDICS; NONHUMAN; ORGAN CULTURE; PHYSICAL CHEMISTRY; PLANT; POSTMARKETING SURVEILLANCE; REVIEW; STEM CELL; TISSUE CULTURE; TOXICITY TESTING;

EID: 81255191882     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474x.89750     Document Type: Review

References (27)

1. Richmond J. Refinement, reduction, and replacement of animal use for regulatory testing: Future improvements and implementation within the regulatory framework. ILAR J 2002;43 Suppl:S63-8. (Pubitemid 135743931)
2. Gallup GG Jr, Suarez SD. Alternatives to the use of animals in psychological research. Am Psychol 1985;40:1104-11.
3. Flecknell PA. Refinement of animal use-assessment and alleviation of pain and distress. Lab Anim 1994;28:222-31. (Pubitemid 24228567)
4. Goldberg AM, Frazier JM. Alternatives to animals in toxicity testing. Sci Am 1989;261:24-30.
5. Stevens CW. Alternatives to the use of mammals for pain research. Life Sci 1992;50:901-12.
6. Russell WM, Burch RL. The Principles of Humane Experimental Technique. Wheathampstead (U. K. ), Reprinted by Universities Federation for Animal Welfare, 1992.
7. Banks RE. The 4th R of Research. Contemp Top Lab Anim Sci 1995;34:43.
8. Schechtman LM. Implementation of the 3Rs (refinement, reduction, and replacement): Validation and regulatory acceptance considerations for alternative toxicological test methods. ILAR J 2002;43Suppl:S85-94. (Pubitemid 135743935)
9. Hendriksen CF. Replacement, reduction and refinement alternatives to animal use in vaccine potency measurement. Expert Rev Vaccines 2009;8:313-22.
10. Lloyd MH, Foden BW, Wolfensohn SE. Refinement: Promoting the three Rs in practice. Lab Anim 2008;42:284-93. (Pubitemid 352029857)
11. Balls M. Replacement of animal procedures: Alternatives in research, education and testing. Lab Anim 1994;28:193-211. (Pubitemid 24228565)
12. Rodriguez-Garcia A, Galan-Wong LJ, Arevalo-Niño K. Development and in vitro evaluation of biopolymers as a delivery system against periodontopathogen microorganisms. Acta Odontol Latinoam 2010;23:158-63.
13. Rana V, Babita K, Goyal D, Gorea R, Tiwary A. Optimization of chitosan film as a substitute for animal and human epidermal sheets for in vitro permeation of polar and non polar drugs. Acta Pharm 2004;54:287-99. (Pubitemid 40143815)
14. Zurlo J, Rudacille D, Goldberg AM. Animals and alternatives in toxicity testing. London: Academic Press; 1983. p. 502.
15. Kim JR, Cha MH, Oh DR, Oh WK, Rhee JH, Kim YR. Resveratrol modulates RTX toxin-induced cytotoxicity through interference in adhesion and toxin production. Eur J Pharmacol 2010;642:163-8.
16. Piersma AH. Alternative methods for developmental toxicity testing. Basic Clin Pharmacol Toxicol. 2006;98:427-31.
17. Trzaska KA, Rameshwar P. Current advances in the treatment of Parkinson's disease with stem cells. Curr Neurovasc Res 2007;4:99-109. (Pubitemid 46708900)
18. Roncaglioni A, Benfenati E. In silico-aided prediction of biological properties of chemicals: Oestrogen receptor-mediated effects. Chem Soc Rev 2008;37:441-50.
19. Festing MF. Reduction of animal use: Experimental design and quality of experiments. Lab Anim 1994;28:212-21. (Pubitemid 24228566)
20. Baglietto L, Giles GG, English DR, Karahalios A, Hopper JL, Severi G. Alcohol consumption and risk of glioblastoma; evidence from the Melbourne collaborative cohort study. Int J Cancer 2011;128:1929-34.
21. Bartha B, Huber C, Harpaintner R, Schröder P. Effects of acetaminophen in Brassica juncea L. Czern. : Investigation of uptake, translocation, detoxification, and the induced defense pathways. Environ Sci Pollut Res Int 2010;17:1553-62.
22. Bremer S, Hartung T. The use of embryonic stem cells for regulatory developmental toxicity testing in vitro-the current status of test development. Curr Pharm Des 2004;10:2733-47. (Pubitemid 39137172)
23. Jenkins ES, Broadhead C, Combes RD. The implications of microarray technology for animal use in scientific research. Altern Lab Anim 2002;30:459-65.
24. Nuwaysir EF, Bittner M, Trent J, Barrett JC, Afshari CA. Microarrays and toxicology: The advent of toxicogenomics. Mol Carcinog 1999;24:153-9. (Pubitemid 29169855)
25. Farris SP, Wolen AR, Miles MF. Using expression genetics to study the neurobiology of ethanol and alcoholism. Int Rev Neurobiol 2010;91:95-128.
26. Bunney WE, Bunney BG, Vawter MP, Tomita H, Li J, Evans SJ, et al. Microarray technology: A review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am J Psychiatry 2003;160:657-66. (Pubitemid 41079596)
27. Yan J, Nunn AD, Thomas R. Selective induction of cell adhesion molecules by proinflammatory mediators in human cardiac microvascular endothelial cells in culture. Int J Clin Exp Med 2010;3:315-31.