Triterpenes from the fungus poria cocos and their inhibitory activity on nitric oxide production in mouse macrophages via blockade of activating protein-1 pathway

Chemistry and Biodiversity

Volumn 8, Issue 11, 2011, Pages 2135-2143

  Cai, Tian Ge ^a   Cai, Yu ^b  

^a LIAONING UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Inhibitors; Pachymic acid; Poria cocos; Structure activity relationship (SAR); Tumulosic acid

Indexed keywords

29 HYDROXYDEHYDROPACHYMIC ACID; 29 HYDROXYDEHYDROTUMULOSIC ACID; 29 HYDROXYPOLYPORENIC ACID C; ANTIINFLAMMATORY AGENT; DEHYDROPACHYMIC ACID; DEHYDROTUMULOSIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) METHYLARGININE; NITRIC OXIDE; PACHYMIC ACID; POLYPORENIC ACID C; TRANSCRIPTION FACTOR AP 1; TRITERPENE DERIVATIVE; TUMULOSIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; GENE EXPRESSION; IC 50; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PORIA COCOS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PORIA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRITERPENES;

FUNGI; PORIA COCOS;

EID: 81255190677     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201100013     Document Type: Article

References (29)

1. T. Tai, Y. Akita, K. Kinoshita, K. Koyama, K. Takahashi, K. Watanabe, Planta Med. 1995, 61, 527.
2. S. M. Fuchs, C. Heinemann, S. Schliemann-Willers, H. Härtl, J. W. Fluhr, P. Elsner, Skin Res. Technol. 2006, 12, 223.
3. E. M. Giner-Larza, S. Máñez, R. M. Giner-Pons, M. C. Recio, J.-L. Ríos, J. Ethnopharmacol. 2000, 73, 61.
4. K. Yasukawa, T. Kaminaga, S. Kitanaka, T. Tai, Y. Nunoura, S. Natori, M. Takido, Phytochemistry 1998, 48, 1357.
5. M. J. Cuélla, R. M. Giner, M. C. Recio, M. J. Just, S. Máñez, J. L. Ríos, J. Nat. Prod. 1996, 59, 977.
6. H. Ling, L. Zhou, X. Jia, L. A. Gapter, R. Agarwal, K.-Y. Ng, Mol. Carcinog. 2009, 48, 498.
7. T. Akihisa, E. Uchiyama, T. Kikuchi, H. Tokuda, T. Suzuki, Y. Kimura, J. Nat. Prod. 2009, 72, 1786.
8. L. Zhou, Y. Zhang, L. A. Gapter, H. Ling, R. Agarwal, K.-Y. Ng, Chem. Pharm. Bull. 2008, 56, 1459.
9. M. Zhang, L. C.-M. Chiu, P. C. K. Cheung, V. E. C. Ooi, Oncol. Rep. 2006, 15, 637.
10. G. H. Li, Y. M. Shen, K. Q. Zhang, J. Microbiol. 2005, 43, 17.
11. X. Wu, J. Yang, L. Zhou, Y. Dong, Chem. Pharm. Bull. (Tokyo) 2004, 52, 1375.
12. H. Li, L. Wang, S. Miyata, S. Kitanaka, J. Nat. Prod. 2008, 71, 739.
13. C.-M. Ma, N. Nakamura, M. Hattori, H. Kakuda, J.-C. Qiao, H.-L. Yu, J. Nat. Prod. 2000, 63, 238.
14. T. Tai, T. Shingu, T. Kikuchi, Y. Tezuka, A. Akahori, Phytochemistry 1995, 40, 225.
15. T. Tai, T. Shingu, T. Kikuchi, Y. Tezuka, A. Akahori, Phytochemistry 1995, 39, 1165.
16. T. Shingu, T. Tai, A. Akahori, Phytochemistry 1992, 31, 2548.
17. Y. Mizushina, T. Akihisa, M. Ukiya, C. Murakami, I. Kuriyama, X. Xu, H. Yoshida, K. Sakaguchi, Cancer Sci. 2004, 95, 354.
18. Q. Wang, X. N. Tang, M. A. Yenari, J. Neuroimmunol. 2007, 184, 53.
19. K. Yamagata, S. Ichinose, A. Miyashita, M. Tagami, Neuroscience 2008, 153, 428.
20. P. C. Zeidler, A. Hubbs, L. Battelli, V. Castranova, J. Toxicol. Environ. Health, Part A 2004, 67, 1001.
21. P. R. Eynott, N. Paavolainen, D. A. Groneberg, A. Noble, M. Salmon, P. Nath, S.-Y. Leung, K. F. Chung, J. Pharmacol. Exp. Ther. 2003, 304, 22.
22. B. Liu, H.-M. Gao, J.-Y. Wang, G.-H. Jeohn, C. L. Cooper, J.-S. Hong, Ann. N.Y. Acad. Sci. 2002, 962, 318.
23. K. Spelman, J. J. Burns, D. Nichols, N. Winters, S. Ottersberg, M. Tenborg, Altern. Med. Rev. 2006, 11, 128.
24. Y. Xia, V. L. Dawson, T. M. Dawson, S. H. Snyder, J. L. Zweier, Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 6770.
25. L. M. Landino, B. C. Crews, M. D. Timmons, J. D. Morrow, L. J. Marnett, Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 15069.
26. M. A. Packer, C. M. Porteous, M. P. Murphy, Biochem. Mol. Biol. Int. 1996, 40, 527.
27. V. Castranova, Free Radical Biol. Med. 2004, 37, 916.
28. H. K. Kim, B. S. Cheon, Y. H. Kim, S. Y. Kim, H. P. Kim, Biochem. Pharmacol. 1999, 58, 759.
29. L. Wang, Y.-C. Tu, T.-W. Lian, J.-T. Hung, J.-H. Yen, M.-J. Wu, J. Agric. Food Chem. 2006, 54, 9798.