Desperately seeking diarrhoea: Outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009

Zoonoses and Public Health

Volumn 58, Issue 8, 2011, Pages 567-572

  Nielsen, S ^a,b   Frank, C ^b   Fruth, A ^b   Spode, A ^c   Prager, R ^b   Graff, A ^d   Plenge Bonig A ^d   Loos, S ^e   Lutgehetmann M ^e   Kemper, M J ^e   Muller Wiefel D E ^e   Werber, D ^b  

^a EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ECDC   (Sweden)

^b ROBERT KOCH INSTITUTE   (Germany)

^c Local Health Department Altona   (Germany)

^d Dr Brill Partner GmbH Institute for Hygiene and Microbiology   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Disease outbreaks; Epidemiological studies; Escherichia coli O157; Haemolytic uraemic syndrome; Shiga toxigenic Escherichia coli

Indexed keywords

SORBITOL;

ARTICLE; CHILD; DIARRHEA; ENVIRONMENTAL EXPOSURE; FECES ANALYSIS; FEMALE; GERMANY; HEALTH SURVEY; HEMOLYTIC UREMIC SYNDROME; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PATHOGENICITY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SHIGA TOXIN PRODUCING ESCHERICHIA COLI;

CHILD; CHILD, PRESCHOOL; DIARRHEA; DISEASE OUTBREAKS; ENVIRONMENTAL EXPOSURE; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI O157; FECES; FEMALE; GERMANY; HEMOLYTIC-UREMIC SYNDROME; HUMANS; INFANT; INTERVIEWS AS TOPIC; MALE; PLAY AND PLAYTHINGS; RISK FACTORS; SHIGA-TOXIGENIC ESCHERICHIA COLI; SORBITOL;

ESCHERICHIA COLI;

EID: 81255187829     PISSN: 18631959     EISSN: 18632378     Source Type: Journal    
DOI: 10.1111/j.1863-2378.2011.01405.x     Document Type: Article

References (19)

1. Ahn, C. K., E. Klein, and P. I. Tarr, 2008: Isolation of patients acutely infected with Escherichia coli O157:H7: low-tech, highly effective prevention of hemolytic uremic syndrome. Clin. Infect. Dis. 46, 1197-1199.
2. Alpers, K., D. Werber, C. Frank, J. Koch, A. W. Friedrich, H. Karch, M. an der Heiden, R. Prager, A. Fruth, M. Bielaszewska, G. Morlock, A. Heissenhuber, A. Diedler, A. Gerber, and A. Ammon, 2009: Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children. Epidemiol. Infect. 137, 389-395.
3. Ammon, A., L. R. Petersen, and H. Karch, 1999: A large outbreak of hemolytic uremic syndrome caused by an unusual sorbitol-fermenting strain of Escherichia coli O157:H. J. Infect. Dis. 179, 1274-1277.
4. Bielaszewska, M., R. Köck, A. W. Friedrich, C. von Eiff, L. B. Zimmerhackl, H. Karch, and A. Mellmann, 2007: Shiga toxin-mediated hemolytic uremic syndrome: time to change the diagnostic paradigm? PLoS One 2, e1024.
5. Gerber, A., H. Karch, F. Allerberger, H. M. Verweyen, and L. B. Zimmerhackl, 2002: Clinical course and the role of Shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997-2000, in Germany and Austria: a prospective study. J. Infect. Dis. 186, 493-500.
6. Gould, L. H., C. Bopp, N. Strockbine, R. Atkinson, V. Baselski, B. Body, R. Carey, C. Crandall, S. Hurd, R. Kaplan, M. Neill, S. Shea, P. Somsel, M. Tobin-D'Angelo, P. M. Griffin, and P. Gerner-Smidt, 2009a: Recommendations for diagnosis of shiga toxin-producing Escherichia coli infections by clinical laboratories. MMWR. Recomm. Rep. 58, 1-14.
7. Gould, L. H., L. Demma, T. F. Jones, S. Hurd, D. J. Vugia, K. Smith, B. Shiferaw, S. Segler, A. Palmer, S. Zansky, and P. M. Griffin, 2009b: Hemolytic uremic syndrome and death in persons with Escherichia coli O157:H7 infection, foodborne diseases active surveillance network sites, 2000-2006. Clin. Infect. Dis. 49, 1480-1485.
8. Griffin, P. M., and R. V. Tauxe, 1991: The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome. Epidemiol. Rev. 13, 60-98.
9. Herikstad, H., S. Yang, T. J. Van Gilder, D. Vugia, J. Hadler, P. Blake, V. Deneen, B. Shiferaw, and F. J. Angulo, 2002: A population-based estimate of the burden of diarrhoeal illness in the United States: FoodNet, 1996-1997. Epidemiol. Infect. 129, 9-17.
10. Hildebrand, J. M., H. C. Maguire, R. E. Holliman, and E. Kangesu, 1996: An outbreak of Escherichia coli O157 infection linked to paddling pools. Commun. Dis. Rep. CDR Rev. 6, R33-R36.
11. Imhoff, B., D. Morse, B. Shiferaw, M. Hawkins, D. Vugia, S. Lance-Parker, J. Hadler, C. Medus, M. Kennedy, M. R. Moore, and T. Van Gilder, 2004: Burden of self-reported acute diarrheal illness in FoodNet surveillance areas, 1998-1999. Clin. Infect. Dis. 38(Suppl 3), S219-S226.
12. Karch, H., R. Wiss, H. Gloning, P. Emmrich, S. Aleksic, and J. Bockemühl, 1990: Hemolytic-uremic syndrome in infants due to verotoxin-producing Escherichia coli. Dtsch. Med. Wochenschr. 115, 489-495.
13. Orth, D., K. Grif, L. B. Zimmerhackl, and R. Würzner, 2009: Sorbitol-fermenting Shiga toxin-producing Escherichia coli O157 in Austria. Wien. Klin. Wochenschr. 121, 108-112.
14. Pollock, K. G., M. E. Locking, T. J. Beattie, H. Maxwell, I. Ramage, D. Hughes, J. Cowieson, L. Allison, M. Hanson, and J. M. Cowden, 2010: Sorbitol-fermenting Escherichia coli O157, Scotland. Emerg. Infect. Dis. 16, 881-882.
15. Rangel, J. M., P. H. Sparling, C. Crowe, P. M. Griffin, and D. L. Swerdlow, 2005: Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002. Emerg. Infect. Dis. 11, 603-609.
16. Rosser, T., T. Dransfield, L. Allison, M. Hanson, N. Holden, J. Evans, S. Naylor, R. La Ragione, J. C. Low, and D. L. Gally, 2008: Pathogenic potential of emergent sorbitol-fermenting Escherichia coli O157:NM. Infect. Immun. 76, 5598-5607.
17. Tarr, P. I., C. A. Gordon, and W. L. Chandler, 2005: Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365, 1073-1086.
18. The Norwegian Institute of Public Health, 2009: Increase in the Number of EHEC Infections in Norway 2009 [Økning i antall EHEC-infeksjoner i Norge 2009]. Nasjonalt folkehelseinstitutt, Oslo. Available at: (accessed 22 March 2011).
19. Werber, D., S. C. Behnke, A. Fruth, R. Merle, S. Menzler, S. Glaser, L. Kreienbrock, R. Prager, H. Tschäpe, P. Roggentin, J. Bockemühl, and A. Ammon, 2007: Shiga toxin-producing Escherichia coli infection in Germany: different risk factors for different age groups. Am. J. Epidemiol. 165, 425-434.