Propranolol therapy in 55 infants with infantile hemangioma: Dosage, duration, adverse effects, and outcome

Pediatric Dermatology

Volumn 28, Issue 6, 2011, Pages 640-644

  Schupp, Christine J ^a   Kleber, Johann Baptist ^a   Günther, Patrick ^a   Holland Cunz, Stefan ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROPRANOLOL;

ARTICLE; ASTHMA; BODY GROWTH; BRONCHITIS; CAPILLARY HEMANGIOMA; CLINICAL TRIAL; COLD LIMB; CRYOTHERAPY; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DRY SKIN; FATIGUE; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; INFANT; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PARENTAL ATTITUDE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RASH; RELAPSE; REMISSION; RISK ASSESSMENT; TREATMENT DURATION; TREATMENT RESPONSE; VITAL SIGN;

ADRENERGIC BETA-ANTAGONISTS; FEMALE; HEMANGIOMA, CAPILLARY; HUMANS; INFANT; MALE; NEOPLASTIC SYNDROMES, HEREDITARY; PROPRANOLOL; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 81255136219     PISSN: 07368046     EISSN: 15251470     Source Type: Journal    
DOI: 10.1111/j.1525-1470.2011.01569.x     Document Type: Article

References (20)

1. Léauté-LabrÃze C, Dumas de la Roque E, Hubiche T, et al., Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 12: 358.
2. Sans V, De la Roque ED, Berge J, et al., Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics 2009; 124: e423-e431.
3. Yeh I, Bruckner AL, Sanchez R, et al., Diffuse infantile hepatic hemangiomas: a report of four cases successfully managed with medical therapy. Pediatr Dermatol 2011; 26: 267-275. DOI
4. Fuchsmann C, Quintal MC, Giguere C, et al., Propranolol as first-line treatment of head and neck hemangiomas. Arch Otolaryngol Head Neck Surg 2011; 137: 471-478.
5. de Graaf M, Breur JM, Raphal MF, et al., Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. J Am Acad Dermatol 2011; 19: 320-327.
6. Kim LH, Hogeling M, Wargon O, et al., Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas. J Pediatr Surg 2011; 46: 759-763.
7. Erbay A, Sarialioglu F, Malbora B, et al., Propranolol for infantile hemangiomas: a preliminary report on efficacy and safety in very low birth weight infants. Turk J Pediatr 2010; 52: 450-456.
8. Peridis S, Pilgrim G, Athanasopoulos I, et al., A meta-analysis on the effectiveness of propranolol for the treatment of infantile airway haemangiomas. Int J Pediatr Otorhinolaryngol 2011; 75: 455-460.
9. Holmes WJ, Mishra A, Gorst C, et al., Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas. J Plast Reconstr Aesthet Surg 2011; 64: 445-451.
10. Rosbe KW, Suh KY, Meyer AK, et al., Propranolol in the management of airway infantile hemangiomas. Arch Otolaryngol Head Neck Surg 2010; 136: 658-665.
11. Zvulunov A, McCuaig C, Frieden IJ, et al., Oral propranolol therapy for infantile hemangiomas beyond the proliferation phase: a multicenter retrospective study. Pediatr Dermatol 2011; 28: 94-98.
12. Lawley LP, Siegfried E, Todd JL,. Propranolol treatment for hemangioma of infancy: risks and recommendations. Pediatr Dermatol 2009; 5: 610-614.
13. Holland KE, Frieden IJ, Frommelt PC, et al., Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol 2010; 146: 775-778.
14. Bonifazi E, Acquafredda A, Milano A, et al., Severe hypoglycemia during successful treatment of diffuse hemangiomatosis with propranolol. Pediatr Dermatol 2010; 27: 195-196.
15. Buckmiller LM,. Propranolol treatment for infantile hemangiomas. Curr Opinion Otolarynol Head Neck Surg 2009; 17: 458-459.
16. Love JN, Sikka N,. Are 1-2 tablets dangerous? Beta-blocker exposure in toddlers J Emerg Med 2004; 26: 309-314. (Pubitemid 38340830)
17. Siegfried EC, Keenan WJ, Al-Jureidini S,. More on propranolol for hemangiomas of infancy. N Engl J Med 2008; 359: 2846-2847.
18. Burns CM, Rutherford MA, Boardman JP, et al., Patterns of cerebral injury and neuropathologic outcomes after symptomatic neonatal hypoglycaemia. Pediatrics 2008; 122: 65-74.
19. AWMF of Society of German Pediatric Surgery, Pediatrics, and Dermatology. Guidelines for therapy of infantile hemangiomas, 2009. Available online at. Accessed on September 1, 2009.
20. Rizzo C, Brightman L, Chapas AM, et al., Outcomes of childhood hemangiomas treated with the pulsed-dye laser with dynamic cooling: a retrospective chart analysis. Dermatol Surg 2009; 35: 1947-1954.