Propranolol: Useful therapeutic agent for the treatment of ulcerated infantile hemangiomas

Journal of Pediatric Surgery

Volumn 46, Issue 4, 2011, Pages 759-763

  Kim, Lawrence H C ^a   Hogeling, Marcia ^a   Wargon, Orli ^a   Jiwane, Ashish ^a   Adams, Susan ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

Infantile hemangioma; Propranolol; Ulceration

Indexed keywords

ALGINIC ACID; AQUACEL AG; CHLORAMPHENICOL; MEPILEX AG; PREDNISOLONE; PROPRANOLOL; SILVER; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG INDICATION; DRUG MEGADOSE; FEMALE; HEMANGIOMA; HUMAN; INFANT; PRIORITY JOURNAL; SKIN ULCER; THORAX WALL TUMOR; TREATMENT DURATION; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; FEMALE; FOLLOW-UP STUDIES; HEMANGIOMA; HUMANS; INFANT; MALE; PROPRANOLOL; SKIN NEOPLASMS; SKIN ULCER; WOUND HEALING;

EID: 79954504261     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2011.01.012     Document Type: Article

References (45)

1. Drolet B.A., Esterly N.B., and Frieden I.J. Hemangiomas in children N Engl J Med 341 3 1999 173 181 (Pubitemid 29325746)
2. Bruckner A.L., and Frieden I.J. Hemangiomas of infancy J Am Acad Dermatol 48 4 2003 477 493 (Pubitemid 36397008)
3. Pandey A., Gangopadhyay A.N., and Sharma S.P. Conservative management of ulcerated haemangioma-twenty years experience Int Wound J 6 2009 59 62
4. Metz B.J., Rubenstein M.C., and Levy M.L. Response of ulcerated perineal hemangiomas of infancy to becaplermin gel, a recombinant human platelet-derived growth factor Arch Dermatol 140 2004 867 870 (Pubitemid 38917857)
5. Sans V., Dumas D.L.R., and Berge J. Propranolol for severe infantile hemangiomas: follow-up report Pediatrics 124 2009 423 431
6. Mousa W., Kues K., and Haas E. Successful treatment of a large hemangioma with propranolol J Dtsch Dermatol Ges 8 3 2010 184 186
7. Naouri M., Schill T., and Maruani A. Successful treatment of ulcerated haemangioma with propranolol J Eur Acad Dermatol Venereol 24 9 2010 1109 1112
8. Metry D.W., and Hebert A.A. Benign cutaneous vascular tumors of infancy when to worry, what to do Arch Dermatol 136 2000 905 914 (Pubitemid 30604290)
9. Haggstrom A.N., Drolet B.A., and Baselga E. Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics J Pediatr 150 3 2007 291 294 (Pubitemid 46328964)
10. Jacobs A.H., and Walton R.G. The incidence of birthmarks in the neonate Pediatrics 58 2 1976 218 222
11. Garzon M.C., Drolet B.A., and Baselga E. Comparison of infantile hemangiomas in preterm and term infants: a prospective study Arch Dermatol 144 2008 1231 1232
12. Wananukul S., and Chatproedprai S. Ulcerated hemangiomas: clinical features and management J Med Assoc Thai 85 2002 1220 1225 (Pubitemid 36255034)
13. Kim H.J., Colombo M., and Frieden I.J. Ulcerated hemangiomas: clinical characteristics and response to therapy J Am Acad Dermatol 44 2001 962 972 (Pubitemid 32493447)
14. Hermans D.J., Boezeman J.B., and Van de Kerkhof P.C. Differences between ulcerated and non-ulcerated hemangioma, a retrospective study of 465 cases Eur J Dermatol 19 2 2009 152 156
15. Batniji R.K., Buckingham E.D., and Williams E.F. III An aesthetic approach to facial hemangiomas Arch Facial Plast Surg 7 5 2005 301 306 (Pubitemid 43973812)
16. Razon M.J., Kraling B.M., and Mulliken J.B. Increased apoptosis coincides with onset of involution in infantile hemangioma Microcirculation 5 2-3 1998 189 195 (Pubitemid 128647894)
17. Haggstrom A.N., Drolet B.A., and Baselga E. Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment Pediatrics 118 3 2006 882 887 (Pubitemid 46091612)
18. Chamlin S.L., Haggstrom A.N., and Drolet B.A. Multicenter prospective study of ulcerated hemangiomas J Pediatr 151 2007 684 689
19. Thomas RF, Hornung RL, Manning SC, et al. Hemangiomas of infancy: treatment of ulceration in the head and neck. Arch Facial Plast Surg 2005;7:312-5. Pediatrics. 2006;118(3):882-7. (Pubitemid 43973814)
20. Morelli J.G., Tian Tan O., and Yohn J.J. Treatment of ulcerated hemangiomas in infancy Arch Pediatr Adolesc 148 1994 1104 1106
21. Lacour M., Syed S., and Linward J. Role of the pulsed dye laser in the management of ulcerated capillary haemangiomas Arch Dis Child 74 1996 161 163 (Pubitemid 26057701)
22. David L.R., Malek M.M., and Argenta L.C. Efficacy of pulse dye laser therapy for the treatment of ulcerated haemangiomas: a review of 78 patients Br J Plast Surg 56 2003 317 327 (Pubitemid 36927263)
23. Jorge B.F., Del Pozo J., and Castiñeiras I. Treatment of ulcerated haemangiomas with a non-coherent pulsed light source: brief initial clinical report J Cosmet Laser Ther 10 2008 48 51 (Pubitemid 351360021)
24. Sugarman J.L., Mauro T.M., and Frieden I.J. Treatment of an ulcerated hemangioma with recombinant platelet-derived growth factor Arch Dermatol 138 2002 314 316 (Pubitemid 34226327)
25. Serena T. Wound closure and gradual involution of an infantile hemangioma using a noncontact, low-frequency ultrasound therapy Ostomy Wound Manage. 54 2 2008 68 71
26. Lapidoth M., Ben-Amitai D., and Bhandarkar S. Efficacy of topical application of eosin for ulcerated haemangiomas J Am Acad Dermatol 60 2009 350 351
27. Wasong S.J., Klepeiss S.A., and Zaenglein A.L. Picture of the month. Ulcerated infantile hemangioma Arch Pediatr Adolesc Med 162 9 2008 893 894
28. Akhavan A., and Zippin J.H. Current treatments for infantile hemangiomas J Drugs Dermatol 9 2 2010 176 180
29. Esterly N.B. Cutaneous hemangiomas, vascular stains and malformations, and associated syndromes Curr Probl Pediatr. 26 1 1996 3 39 (Pubitemid 126838691)
30. Bennett M.L., Fleischer A.B., and Chamlin S.L. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation Arch Dermatol 137 9 2001 1208 1213 (Pubitemid 32847844)
31. Rössler J., Wehl G., and Niemeyer C.M. Evaluating systemic prednisone therapy for proliferating haemangioma in infancy Eur J Pediatr 167 2008 813 815 (Pubitemid 351733500)
32. Ashinoff R., and Geronemus R.G. Capillary hemangiomas and treatment with the flash lamp-pumped pulsed dye laser Arch Dermatol 127 2 1991 202 205
33. Hohenleutner S., Badur-Ganter E., and Landthaler M. Long-term results in the treatment of childhood hemangioma with the flashlamp-pumped pulsed dye laser: an evaluation of 617 cases Lasers Surg Med 28 3 2001 273 277 (Pubitemid 32275297)
34. Garden J.M., Bakus A.D., and Paller A.S. Treatment of cutaneous hemangiomas by the flashlamp-pumped pulsed dye laser: prospective analysis J Pediatr. 120 4 Pt 1 1992 555 560
35. Witman P.M., Wagner A.M., and Scherer K. Complications following pulsed dye laser treatment of superficial hemangiomas Lasers Surg Med 38 2006 116 123
36. Rizzo C., Brightman L., and Chapas A.M. Outcomes of childhood hemangiomas treated with the pulsed-dye laser with dynamic cooling: a retrospective chart analysis Dermatol Surg. 35 12 2009 1947 1954
37. Spector J.A., Blei F., and Zide B. Early surgical intervention for proliferating hemangiomas of the scalp: indications and outcomes Plast Reconstr Surg 122 2008 457 462
38. Frieden I.J. Special symposium: management of hemangiomas Pediatr Dermatol 14 1997 57 83
39. Mulliken J.B., Rogers G.F., and Marler J.J. Circular excision of hemangioma and purse-string closure: the smallest possible scar Plast Reconstr Surg 109 5 2002 1544 1554 (Pubitemid 34273359)
40. Leaute-Labreze C., Dumas D.L.R., and Hubiche T. Propranolol for severe hemangiomas of infancy N Engl J Med 358 2008 2649 2651 (Pubitemid 351831393)
41. Buckmiller L.M. Propranolol treatment for infantile hemangiomas Curr Opin Otolaryngol Head Neck Surg 17 2009 458 459
42. Siegfried E.C., Keenan W.J., and Al Jureidini S. More on propranolol for hemangiomas of infancy N Engl J Med 359 2008 2846 2847
43. D'Angelo G., Lee H., and Weiner R.I. cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation J Cell Biochem 67 1997 353 366 (Pubitemid 27509471)
44. Sommers Smith S.K., and Smith D.M. Beta blockade induces apoptosis in cultured capillary endothelial cells In Vitro Cell Dev Biol Anim 38 2002 298 304 (Pubitemid 35204978)
45. Holland K.E., Frieden I.J., and Frommelt P.C. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma Arch Dermatol 146 7 2010 775 778