In nephrotic syndromes podocytes synthesize and excrete proteins into the tubular fluid: An electron and ion microscopic study

Comptes Rendus - Biologies

Volumn 334, Issue 10, 2011, Pages 713-719

  Galle, Pierre ^a   Labejof, Lise ^a  

^a DEPARTAMENTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

Author keywords

Glomerulus; Ion microscopy; Nephrotic syndrome; Permeability; Proteinuria; SIMS

Indexed keywords

NITROGEN; SULFUR;

CYTOPLASM; MICROSCOPY; NITROGEN; PERMEABILITY; PROTEIN; QUANTITATIVE ANALYSIS; SULFUR;

ARTICLE; CELL NUCLEUS; CELL VACUOLE; CHILD; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CYTOPLASM; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ERGASTOPLASM; HUMAN; INFANT; KIDNEY BIOPSY; NEPHROTIC SYNDROME; PODOCYTE; PRESCHOOL CHILD; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; PROTEINURIA; SCANNING ION MICROSCOPY; SCHOOL CHILD; TRANSMISSION ELECTRON MICROSCOPY;

BIOPSY; CELL NUCLEUS; CHILD; CHILD, PRESCHOOL; CHROMATIN; CYTOPLASM; ENDOPLASMIC RETICULUM; FEMALE; HEMATURIA; HUMANS; INFANT; INFANT, NEWBORN; KIDNEY; KIDNEY TUBULES; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NEPHROTIC SYNDROME; PODOCYTES; PROTEINURIA; TISSUE FIXATION; VACUOLES;

EID: 81155162487     PISSN: 16310691     EISSN: 17683238     Source Type: Journal    
DOI: 10.1016/j.crvi.2011.06.006     Document Type: Article

References (16)

1. B. Haraldsson, J. Nystrom, and W. Deen Properties of the glomerular barrier and mechanism of proteinuria Physiol. Rev. 88 2008 451 487 (Pubitemid 351522745)
2. B. Haraldsson, and J. Sorensson Why do not all have Proteinuria? An update of our current understanding of the glomerular barrier News Physiol. Sci. 19 2004 7 10
3. H. Pavenstadt, W. Kriz, and M. Kretzler Cell biology of the glomerular podocyte Physiol. Rev. 83 2003 253 307 (Pubitemid 36459882)
4. A.H.J. Salmon, C.R. Neal, and S.J. Herper New aspects on glomerular filtration barrier structure and function: five layers (at least) and not three Curr. Opin. Nephrol. Hypertens. 48 2009 197 205
5. K. Tryggvason, J. Patrakka, and J. Wartiovaa Mechanism of disease: Hereditary proteinuria syndromes and mechanism of proteinuria N. Engl. J. Med. 354 2006 1387 1401
6. E. Pachuca, G. Benoit, and C. Antigenic Genetic of nephritic syndrome: connecting molecular genetics to podocyte physiology Hum. Mol. Genet. 18 Review issue 2 2009 R185 R194
7. C. Lechene, F. Hillion, G. MacMahon, D. Benson, A.M. Kleifeld, J.P.C. Kampf, D. Distel, Y. Luyten, J. Bonventre, D. Hentshel, K.M. Park, S. Ito, M. Schwartz, G. Benichou, and G. Slodzian High resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry J. Biol. 5 2006 20 30
8. J.L. Guerquin-Kern, W. Ting-Di, C. Quintana, and A. Croisy Progress in analytical imaging of the cell by dynamic Secondary Ion Mass Spectrometry (SIMS microscopy) Biochim. Biophys. Acta 1724 2005 228 238 (Pubitemid 41080032)
9. G. Slodzian, and P. Galle Cartographie de matériaux et d'échantillons biologiques par microscopie ionique balayage C. R. Acad. Sci. 9 3 1992 157 177
10. R. Levi-Setti, J. M'Chabala, R. Gravilov, R. Espinosa III, and M. LeBeau Advances in high resolution SIMS studies of BrdU-labelled human metaphasachromosomes Cell. Mol. Biol. 42 1996 301 324
11. M.G. Farquhar, R.L. Vernier, and R.A. Good Studies on familial nephrosis II: Glomerular changes observed with the electron microscope Am. J. Pathol. 33 1957 791 817
12. C. Oberling, A. Gautier, and W. Bernhard La structure des capillaires glomérulaires vue au microscope électronique Presse Med. 59 1951 938 940
13. J.F. Rinehart Fine structure of renal glomerulus as revealed by electron microscopy A.M.A. Arch. Path. 59 1955 439 448
14. P. Galle, and P. Mahieu Electron dense alteration of kidney basement membranes: a renal lesion specific of a systemic disease Am. J. Med. 58 1975 749 764
15. M. Kestila, U. Lenkkeri, M. Mannikko, J. Lamerdin, P. McCreadi, H. Putaala, V. Ruotsalinen, T. Morita, M. Nissinen, R. Herva, C.E. Kastan, L. Peltonen, C. Holmberg, A. Holsen, and K. Tryggvason Positionally cloned gene for a novel glomerular protein-nephrin is mutated in congenital nephritic syndrome Mol. Cell. 1 1998 575 582 (Pubitemid 128374693)
16. P. Galle Cellules rénales Le concours medical 96 1974 67 84