Staphylococcal α-toxin induces a higher T cell proliferation and interleukin-31 in atopic dermatitis

International Archives of Allergy and Immunology

Volumn 156, Issue 4, 2011, Pages 412-415

  Niebuhr, Margarete ^a   Mamerow, Diana ^a   Heratizadeh, Annice ^a   Satzger, Imke ^a   Werfel, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Toxin; Atopic dermatitis; Interleukin 31; Peripheral blood mononuclear cells; T cell proliferation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 31; INTERLEUKIN 9; STAPHYLOCOCCUS ALPHA TOXIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SKIN INFLAMMATION; SKIN PRURITUS; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; UPREGULATION;

BACTERIAL TOXINS; CELLS, CULTURED; CYTOKINES; DERMATITIS, ATOPIC; HEMOLYSIN PROTEINS; HUMANS; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 81155159184     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000323905     Document Type: Article

References (13)

1. Werfel T: The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol 2009; 129: 1878-1891.
2. Breuer K, Wittmann M, Kempe K, Kapp A, Mai U, Dittrich-Breiholz O, et al:-Toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis. Clin Exp Allergy 2005; 35: 1088-1095. (Pubitemid 41603144)
3. Wichmann K, Uter W, Weiss J, Breuer K, Heratizadeh A, Mai U, et al: Isolation of-toxin-producing Staphylococcus aureus from the skin of highly sensitized adult patients with severe atopic dermatitis. Br J Dermatol 2009; 161: 300-305.
4. Dinges MM, Orwin PM, Schlievert PM: Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 2000; 13: 16-34. (Pubitemid 30039341)
5. Niebuhr M, Scharonow H, Gathmann M, Mamerow D, Werfel T: Staphylococcal exotoxins are strong inducers of interleukin (IL)-22: a potential role for atopic dermatitis. J Allergy Clin Immunol 2010;126:1176-1183.
6. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J, Steinhoff M, Hoffmann TK, Ruzicka T, Zlotnik A, Homey B: IL-31:a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006; 117: 411-417. (Pubitemid 43192023)
7. Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR et al: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 2004; 5: 752-760. (Pubitemid 39023308)
8. Raap U, Wichmann K, Bruder M, Stander S, Wedi B, Kapp A et al: Correlation of IL-31 serum levels with severity of atopic dermatitis. J Allergy Clin Immunol 2008; 122: 421-423.
9. Neis MM, Peters B, Dreuw A, Wenzel J, Bieber T, Mauch C et al: Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol 2006; 118: 930-937. (Pubitemid 44498762)
10. Kasraie S, Niebuhr M, Werfel T: Interleukin (IL)-31 induces pro-inflammatory cytokines in human macrophages and PBMCs upon stimulation with staphylococcal exotoxins. Allergy 2010; 65: 712-721.
11. Ip WK, Wong CK, Li ML, Li PW, Cheung PF, Lam CW: Interleukin-31 induces cytokine and chemokine production from human bronchial epithelial cells through activation of mitogen-activated protein kinase signalling pathways: implications for the allergic response. Immunology 2007; 122: 532-541. (Pubitemid 350075949)
12. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92(suppl):44-47.
13. Munoz-Planillo R, Franchi L, Miller LS, Nunez G: A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus induced activation of the Nlrp3 inflammasome. J Immunol 2009; 183: 3942-3948.