메뉴 건너뛰기




Volumn 46, Issue 8, 2011, Pages 297-308

Fidaxomicin: New therapy for clostridium difficile associated diarrhea

Author keywords

[No Author keywords available]

Indexed keywords

FIDAXOMICIN; METRONIDAZOLE; VANCOMYCIN;

EID: 81155154160     PISSN: 1082801X     EISSN: 19381166     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (38)
  • 2
    • 25144469664 scopus 로고    scopus 로고
    • Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
    • Warny M, Pepin J, Fang A, et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet. 2005;366:1079-1084.
    • (2005) Lancet , vol.366 , pp. 1079-1084
    • Warny, M.1    Pepin, J.2    Fang, A.3
  • 3
    • 34247643644 scopus 로고    scopus 로고
    • Colitis due to Clostridium difficile toxins: Underdiagnosed, highly virulent, and nosocomial
    • Fordtran JS. Colitis due to Clostridium difficile toxins: underdiagnosed, highly virulent, and nosocomial. Proc (Bayl Univ Med Cent). 2006;19:3-12.
    • (2006) Proc (Bayl Univ Med Cent) , vol.19 , pp. 3-12
    • Fordtran, J.S.1
  • 4
    • 33748563622 scopus 로고    scopus 로고
    • EU Member States, and the European Centre for Disease Prevention and Control. Emergence of Clostridium difficile-associated disease in North America and Europe
    • for the ESCMID Study Group for Clostridium difficile
    • Kuijper EJ, Coignard B, Tüll P, for the ESCMID Study Group for Clostridium difficile, EU Member States, and the European Centre for Disease Prevention and Control. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect. 2006;12(Suppl 6):2-18.
    • (2006) Clin Microbiol Infect , vol.12 , Issue.6 SUPPL. , pp. 2-18
    • Kuijper, E.J.1    Coignard, B.2    Tüll, P.3
  • 5
    • 2342426803 scopus 로고    scopus 로고
    • Clostridium difficile associated diarrhea in hospitalised patients: Onset in the community and hospital and role of fl exible sigmoidoscopy
    • Johal SS, Hammond J, Solomon K, James PD, Mahida YR. Clostridium difficile associated diarrhea in hospitalised patients: onset in the community and hospital and role of fl exible sigmoidoscopy. Gut. 2004;53:673-677.
    • (2004) Gut , vol.53 , pp. 673-677
    • Johal, S.S.1    Hammond, J.2    Solomon, K.3    James, P.D.4    Mahida, Y.R.5
  • 6
    • 33947234953 scopus 로고    scopus 로고
    • Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: A controlled interrupted time series
    • Fowler S, Webber A, Cooper BS, et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother. 2007;59:990-995.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 990-995
    • Fowler, S.1    Webber, A.2    Cooper, B.S.3
  • 7
    • 0029818791 scopus 로고    scopus 로고
    • Cleaning up Clostridium difficile infection
    • Wilcox MH. Cleaning up Clostridium difficile infection. Lancet. 1996;348:767-768.
    • (1996) Lancet , vol.348 , pp. 767-768
    • Wilcox, M.H.1
  • 8
    • 81155157231 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, Available at:, Accessed July 7, 2011
    • Centers for Disease Control and Prevention. Frequently asked questions about C. difficile for healthcare providers. Available at: http://www. cdc.gov/HAI/organisms/cdiff/Cdiff_faqs_ HCP.html. Accessed July 7, 2011.
    • Frequently Asked Questions About C. Difficile For Healthcare Providers
  • 9
    • 0021038539 scopus 로고
    • Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhea and colitis
    • Teasley DG, Gerding DN, Olson MM, et al. Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhea and colitis. Lancet. 1983;2:1043-1046.
    • (1983) Lancet , vol.2 , pp. 1043-1046
    • Teasley, D.G.1    Gerding, D.N.2    Olson, M.M.3
  • 10
    • 33644523410 scopus 로고    scopus 로고
    • Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003
    • McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis. 2006;12:409-415.
    • (2006) Emerg Infect Dis , vol.12 , pp. 409-415
    • McDonald, L.C.1    Owings, M.2    Jernigan, D.B.3
  • 11
    • 19344364596 scopus 로고    scopus 로고
    • Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole
    • Musher DM, Aslam S, Logan N, et al. Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole. Clin Infect Dis. 2005;40:1586-1590.
    • (2005) Clin Infect Dis , vol.40 , pp. 1586-1590
    • Musher, D.M.1    Aslam, S.2    Logan, N.3
  • 12
    • 19344363493 scopus 로고    scopus 로고
    • Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada
    • Pepin J, Alary ME, Valiquette L, et al. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis. 2005;40:1591-1597.
    • (2005) Clin Infect Dis , vol.40 , pp. 1591-1597
    • Pepin, J.1    Alary, M.E.2    Valiquette, L.3
  • 13
    • 28844441314 scopus 로고    scopus 로고
    • A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    • Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005;353:2442-2449.
    • (2005) N Engl J Med , vol.353 , pp. 2442-2449
    • Loo, V.G.1    Poirier, L.2    Miller, M.A.3
  • 14
    • 28844494086 scopus 로고    scopus 로고
    • An epidemic, toxin gene-variant strain of Clostridium difficile
    • McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med. 2005;353:2433-2441.
    • (2005) N Engl J Med , vol.353 , pp. 2433-2441
    • McDonald, L.C.1    Killgore, G.E.2    Thompson, A.3
  • 15
    • 27444437759 scopus 로고    scopus 로고
    • Emergence of fl uoroquinolones as the predominant risk factor for Clostridium diffi - cile-associated diarrhea: A cohort study during an epidemic in Quebec
    • Pepin J, Saheb N, Coulombe MA, et al. Emergence of fl uoroquinolones as the predominant risk factor for Clostridium diffi - cile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis. 2005;41:1254-1260.
    • (2005) Clin Infect Dis , vol.41 , pp. 1254-1260
    • Pepin, J.1    Saheb, N.2    Coulombe, M.A.3
  • 16
    • 43249103183 scopus 로고    scopus 로고
    • Vancomycin for the treatment of Clostridium difficile infection: For whom is this expensive bullet really magic?
    • Pepin J. Vancomycin for the treatment of Clostridium difficile infection: for whom is this expensive bullet really magic? Clin Infect Dis. 2008;46:1493-1498.
    • (2008) Clin Infect Dis , vol.46 , pp. 1493-1498
    • Pepin, J.1
  • 17
    • 19344363058 scopus 로고    scopus 로고
    • Metronidazole for Clostridium difficile-associated disease: Is it okay for Mom?
    • Gerding DN. Metronidazole for Clostridium difficile-associated disease: is it okay for Mom? Clin Infect Dis. 2005;40:1598-1600.
    • (2005) Clin Infect Dis , vol.40 , pp. 1598-1600
    • Gerding, D.N.1
  • 18
    • 0026495166 scopus 로고
    • Clostridium difficile infection: Responses, relapses, and re-infections
    • Wilcox MH, Spencer RC. Clostridium difficile infection: responses, relapses, and re-infections. J Hosp Infect. 1992;22:85-92
    • (1992) J Hosp Infect , vol.22 , pp. 85-92
    • Wilcox, M.H.1    Spencer, R.C.2
  • 19
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)
    • Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-455.
    • (2010) Infect Control Hosp Epidemiol , vol.31 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3
  • 20
    • 39749121022 scopus 로고    scopus 로고
    • Treatment of Clostridium difficile infection
    • Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. Clin Infect Dis. 2008;46(Suppl 1):S32-S42.
    • (2008) Clin Infect Dis , vol.46 , Issue.1 SUPPL.
    • Gerding, D.N.1    Muto, C.A.2    Owens Jr., R.C.3
  • 21
    • 81155157236 scopus 로고    scopus 로고
    • Difi cid [package insert]. San Diego, Optimer Pharmaceuticals, Inc
    • Difi cid [package insert]. San Diego, CA: Optimer Pharmaceuticals, Inc; 2011.
    • (2011) CA
  • 22
    • 79953166785 scopus 로고    scopus 로고
    • Difi micin; Lipiarmycin; OPT 80; OPT-80; PAR 101; PAR-101
    • Fidaxomicin
    • Fidaxomicin: Difi micin; Lipiarmycin; OPT 80; OPT-80; PAR 101; PAR-101. Drugs R D. 2010;10:37-45.
    • (2010) Drugs R D , vol.10 , pp. 37-45
  • 23
    • 0023250466 scopus 로고
    • Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity
    • Theriault RJ, Karwowski JP, Jackson M, et al. Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity. J Antibiot (Tokyo). 1987;40:567-574.
    • (1987) J Antibiot (Tokyo) , vol.40 , pp. 567-574
    • Theriault, R.J.1    Karwowski, J.P.2    Jackson, M.3
  • 24
    • 79960391202 scopus 로고    scopus 로고
    • Killing kinetics of fi daxomicin and its major metabolite, OP-1118, against Clostridium difficile
    • Feb, 2011;60:1213-1217. EPub
    • Babakhani F, Gomez A, Robert N, Sears P. Killing kinetics of fi daxomicin and its major metabolite, OP-1118, against Clostridium diffi - cile. J Med Microbiol. 2011;60:1213-1217. EPub 2011 Feb. 24.
    • (2011) J Med Microbiol , pp. 24
    • Babakhani, F.1    Gomez, A.2    Robert, N.3    Sears, P.4
  • 25
    • 81155132862 scopus 로고    scopus 로고
    • Optimer Pharmaceuticals Inc, Available at, Accessed July 7, 2011
    • Optimer Pharmaceuticals Inc. Anti-infective drugs advisory committee briefi ng document. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/Anti-InfectiveDrugsAdvisory-Committee/UCM249354.pdf. Accessed July 7, 2011.
    • Anti-infective Drugs Advisory Committee Briefi Ng Document
  • 26
    • 42049099454 scopus 로고    scopus 로고
    • Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses
    • Shue YK, Sears PS, Shangle S, et al. Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses. Antimicrob Agents Chemother. 2008;52:1391-1395.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1391-1395
    • Shue, Y.K.1    Sears, P.S.2    Shangle, S.3
  • 27
    • 59749084849 scopus 로고    scopus 로고
    • Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection
    • Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ. Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium diffi - cile infection. Antimicrob Agents Chemother. 2009;53:223-228.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 223-228
    • Louie, T.1    Miller, M.2    Donskey, C.3    Mullane, K.4    Goldstein, E.J.5
  • 28
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • for the OPT-80-003 Clinical Study Group
    • Louie TJ, Miller MA, Mullane KM, et al, for the OPT-80-003 Clinical Study Group. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med. 2011;64:422-431.
    • (2011) N Engl J Med , vol.64 , pp. 422-431
    • Louie, T.J.1    Miller, M.A.2    Mullane, K.M.3
  • 31
    • 7244250115 scopus 로고    scopus 로고
    • Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species
    • Credito KL, Appelbaum PC. Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species. Antimicrob Agents Chemother. 2004;48:4430-4434.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4430-4434
    • Credito, K.L.1    Appelbaum, P.C.2
  • 32
    • 34547640095 scopus 로고    scopus 로고
    • In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004
    • Hecht DW, Galang MA, Sambol SP, Osmolski JR, Johnson S, Gerding DN. In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob Agents Chemother. 2007;51:2716-2719.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2716-2719
    • Hecht, D.W.1    Galang, M.A.2    Sambol, S.P.3    Osmolski, J.R.4    Johnson, S.5    Gerding, D.N.6
  • 33
    • 55849151684 scopus 로고    scopus 로고
    • In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile
    • Karlowsky JA, Laing NM, Zhanel GG. In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. Antimicrob Agents Chemother. 2008;52:4163-4165.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4163-4165
    • Karlowsky, J.A.1    Laing, N.M.2    Zhanel, G.G.3
  • 34
    • 70549097125 scopus 로고    scopus 로고
    • Typing and susceptibility of bacterial isolates from the fi daxomicin (OPT-80) phase II study for C. difficile infection
    • Citron DM, Babakhani F, Goldstein EJ, et al. Typing and susceptibility of bacterial isolates from the fi daxomicin (OPT-80) phase II study for C. difficile infection. Anaerobe. 2009;15:234-236.
    • (2009) Anaerobe , vol.15 , pp. 234-236
    • Citron, D.M.1    Babakhani, F.2    Goldstein, E.J.3
  • 36
    • 77951231746 scopus 로고    scopus 로고
    • In vitro activity of fi daxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp
    • Biedenbach DJ, Ross JE, Putnam SD, and Jones RN. In vitro activity of fi daxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp. Antimicrob Agents Chemother. 2010;54:2273-2275.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2273-2275
    • Biedenbach, D.J.1    Ross, J.E.2    Putnam, S.D.3    Jones, R.N.4
  • 38
    • 81155127071 scopus 로고    scopus 로고
    • AmerisourceBergen Drug Corporation, Available at, Accessed July 26
    • AmerisourceBergen Drug Corporation. Available at www. amerisourcebergendrug.com. Accessed July 26, 2011.
    • (2011)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.